Anti-IL-17A treatment reduces serum inflammatory, angiogenic and tissue remodeling biomarkers accompanied by less synovial high endothelial venules in peripheral spondyloarthritis

Spondyloarthritis (SpA) is characterized by inflammation and new bone formation. The exact pathophysiology underlying these processes remains elusive. We propose that the extensive neoangiogenesis in SpA could play a role both in sustaining/enhancing inflammation and in new bone formation. While amp...

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Veröffentlicht in:	Scientific reports 2020-12, Vol.10 (1), p.21094-21094, Article 21094
Hauptverfasser:	Kaaij, Merlijn H., Helder, Boy, van Mens, Leonieke J. J., van de Sande, Marleen G. H., Baeten, Dominique L. P., Tas, Sander W.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250 631/250/127 631/250/256 631/250/256/2515 692/4023 692/4023/1670 692/4023/1670/2766 692/4023/1670/2766/1827 692/4023/1670/2766/1900 Angiogenesis Anti-Inflammatory Agents - therapeutic use Antibodies, Monoclonal, Humanized - therapeutic use Arthritis Biomarkers Biomarkers - blood Bone growth Bone remodeling Humanities and Social Sciences Inflammation Inflammatory diseases Interleukin 1 Interleukin 6 Interleukins - blood Joints - blood supply Joints - drug effects Matrix Metalloproteinase 3 - blood multidisciplinary Multidisciplinary Sciences Neovascularization, Physiologic Osteogenesis Osteopontin Osteopontin - blood Rheumatic diseases S100 Proteins - blood Science Science & Technology Science & Technology - Other Topics Science (multidisciplinary) Serum levels Spondylitis, Ankylosing - blood Spondylitis, Ankylosing - drug therapy Tumor necrosis factor-α Vascular endothelial growth factor Vascular Endothelial Growth Factor A - blood Venules - drug effects Venules - physiology
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