Three-dimensional imaging of mitochondrial cristae complexity using cryo-soft X-ray tomography

Mitochondria are dynamic organelles that change morphology to adapt to cellular energetic demands under both physiological and stress conditions. Cardiomyopathies and neuronal disorders are associated with structure-related dysfunction in mitochondria, but three-dimensional characterizations of the...

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Veröffentlicht in:	Scientific reports 2020-12, Vol.10 (1), p.21045-21045, Article 21045
Hauptverfasser:	Polo, Carla C., Fonseca-Alaniz, Miriam H., Chen, Jian-Hua, Ekman, Axel, McDermott, Gerry, Meneau, Florian, Krieger, José E., Miyakawa, Ayumi A.
Format:	Artikel
Sprache:	eng
Schlagworte:	3-D reconstruction 631/1647/245/1847 631/1647/245/2221 631/80/642/333 Animals BASIC BIOLOGICAL SCIENCES Cells, Cultured Cristae Cryopreservation - methods Humanities and Social Sciences Imaging, Three-Dimensional - methods Imaging, Three-Dimensional - standards Invaginations Limit of Detection Mitochondria Mitochondria, Muscle - ultrastructure Morphology multidisciplinary Myocytes, Smooth Muscle - ultrastructure Organelles Rats Science Science (multidisciplinary) Segmentation Spatial discrimination Tomography X-Ray Microtomography - methods X-Ray Microtomography - standards x-ray tomography
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