Significant increase in the secretion of extracellular vesicles and antibiotics resistance from methicillin-resistant Staphylococcus aureus induced by ampicillin stress

Extracellular vesicles (EVs) containing specific cargo molecules from the cell of origin are naturally secreted from bacteria. EVs play significant roles in protecting the bacterium, which can contribute to their survival in the presence of antibiotics. Herein, we isolated EVs from methicillin-resis...

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Veröffentlicht in:	Scientific reports 2020-12, Vol.10 (1), p.21066, Article 21066
Hauptverfasser:	Kim, Si Won, Seo, Jong-Su, Park, Seong Bin, Lee, Ae Rin, Lee, Jung Seok, Jung, Jae Wook, Chun, Jin Hong, Lazarte, Jassy Mary S., Kim, Jaesung, Kim, Jong-Hwan, Song, Jong-Wook, Franco, Chris, Zhang, Wei, Ha, Min Woo, Paek, Seung-Mann, Jung, Myunghwan, Jung, Tae Sung
Format:	Artikel
Sprache:	eng
Schlagworte:	631/326/22/1290 631/326/22/1434 Ampicillin Ampicillin - pharmacology Anti-Bacterial Agents - pharmacology Antibiotics Bacteria Bacterial Proteins - metabolism beta-Lactamase Inhibitors - pharmacology beta-Lactamases - metabolism beta-Lactams - pharmacology Biodegradation Cell-Free System Drug resistance Drug Resistance, Microbial - drug effects Extracellular vesicles Extracellular Vesicles - drug effects Extracellular Vesicles - metabolism Extracellular Vesicles - ultrastructure Humanities and Social Sciences Methicillin Methicillin-Resistant Staphylococcus aureus - drug effects Methicillin-Resistant Staphylococcus aureus - physiology Microbial Sensitivity Tests Minimum inhibitory concentration multidisciplinary Penicillin Science Science (multidisciplinary) Secretion Staphylococcus aureus Staphylococcus infections Stress, Physiological - drug effects β-Lactam antibiotics
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