Stability enhancement in a mAb and Fab coformulation

Multiple therapeutic proteins can be combined into a single dose for synergistic targeting to multiple sites of action. Such proteins would be mixed in dose-specific ratios to provide the correct potency for each component, and yet the formulations must also preserve their activity and keep degradat...

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Veröffentlicht in:	Scientific reports 2020-12, Vol.10 (1), p.21129-21129, Article 21129
Hauptverfasser:	Zhang, Hongyu, Dalby, Paul A.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647 631/45 631/61 Antibodies, Monoclonal - immunology Coalescence Degradation Fab Humanities and Social Sciences Humans Immunoglobulin Fab Fragments - immunology Immunoglobulin G Kinetics Macromolecules Monoclonal antibodies multidisciplinary Proteins Science Science (multidisciplinary) Shelf life
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