A proof of concept ‘phase zero’ study of neurodevelopment using brain organoid models with Vis/near-infrared spectroscopy and electrophysiology

Homeostatic control of neuronal excitability by modulation of synaptic inhibition (I) and excitation (E) of the principal neurons is important during brain maturation. The fundamental features of in-utero brain development, including local synaptic E–I ratio and bioenergetics, can be modeled by cere...

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Veröffentlicht in:	Scientific reports 2020-12, Vol.10 (1), p.20987-20987, Article 20987
Hauptverfasser:	Dutta, Anirban, Karanth, Sneha Sudhakar, Bhattacharya, Mahasweta, Liput, Michal, Augustyniak, Justyna, Cheung, Mancheung, Stachowiak, Ewa K., Stachowiak, Michal K.
Format:	Artikel
Sprache:	eng
Schlagworte:	639/166 692/308 692/617 692/699 Acetyl-L-carnitine Acetylcarnitine - pharmacology Bioenergetics Brain - cytology Brain - drug effects Brain - growth & development Brain - physiology Carnitine Case-Control Studies Cell Line Choline Choline - pharmacology Cytochrome-c oxidase Drug development Electron Transport Complex IV - metabolism Electrophysiology Excitability Female Humanities and Social Sciences Humans I.R. radiation Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Infrared spectroscopy Lipoic acid Male Mental disorders Mitochondria Mitochondria - metabolism multidisciplinary Neurodevelopment Neuromodulation Organoids Organoids - drug effects Organoids - growth & development Organoids - physiology Proof of Concept Study Schizophrenia Schizophrenia - metabolism Science Science (multidisciplinary) Spectroscopy, Near-Infrared Spectrum analysis Synaptogenesis Thioctic Acid - pharmacology Ubiquinone - analogs & derivatives Ubiquinone - pharmacology
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