H3.3G34W promotes growth and impedes differentiation of osteoblast-like mesenchymal progenitors in Giant Cell Tumour of Bone

Glycine 34 to tryptophan (G34W) substitutions in H3.3 arise in ~90% of giant cell tumour of bone (GCT). Here, we show H3.3G34W is necessary for tumour formation. By profiling the epigenome, transcriptome and secreted proteome of patient samples and tumour-derived cells CRISPR/Cas9-edited for H3.3G34...

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Veröffentlicht in:	Cancer discovery 2020-09, Vol.10 (12), p.1968-1987
Hauptverfasser:	Khazaei, Sima, De Jay, Nicolas, Deshmukh, Shriya, Hendrikse, Liam D., Jawhar, Wajih, Chen, Carol C.L., Mikael, Leonie G., Faury, Damien, Marchione, Dylan M., Lanoix, Joel, Bonneil, Éric, Ishii, Takeaki, Jain, Siddhant U., Rossokhata, Kateryna, Sihota, Tianna S., Eveleigh, Robert, Lisi, Véronique, Harutyunyan, Ashot S., Jung, Sungmi, Karamchandani, Jason, Dickson, Brendan C., Turcotte, Robert, Wunder, Jay S., Thibault, Pierre, Lewis, Peter W., Garcia, Benjamin A., Mack, Stephen C., Taylor, Michael D., Garzia, Livia, Kleinman, Claudia L., Jabado, Nada
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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