Molecular Basis of the Polyspecificity of P-Glycoprotein (ABCB1): Recent Biochemical and Structural Studies

ABCB1 (P-glycoprotein/P-gp) is an ATP-binding cassette transporter well known for its association with multidrug resistance in cancer cells. Powered by the hydrolysis of ATP, it effluxes structurally diverse compounds. In this chapter, we discuss current views on the molecular basis of the substrate...

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Veröffentlicht in:	ABC Transporters and Cancer 2015, Vol.125, p.71-96
Hauptverfasser:	Chufan, Eduardo E, Sim, Hong-May, Ambudkar, Suresh V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP Binding Cassette Transporter, Subfamily B - metabolism ATP Binding Cassette Transporter, Subfamily B - ultrastructure Binding Sites - physiology Biological Transport - physiology Caenorhabditis elegans Caenorhabditis elegans Proteins - metabolism Cellular biology Crystallography, X-Ray Drug Resistance, Multiple - physiology Drug Resistance, Neoplasm - physiology Humans Medical genetics Mice Models, Molecular Neoplasms - drug therapy Neoplasms - metabolism Oncology Protein Conformation
Online-Zugang:	Volltext
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