Impact of remnant healthy pulp and apical tissue on outcomes after simulated regenerative endodontic procedure in rat molars
When regenerative endodontic procedures (REPs) are performed on immature teeth diagnosed with pulp necrosis and apical periodontitis, various healing patterns occur. Furthermore, infected immature teeth with endodontic disorders often exhibit some remnant pulp and apical tissue. Therefore, this stud...
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| Veröffentlicht in: | Scientific reports 2020-12, Vol.10 (1), p.20967-20967, Article 20967 |
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| creator | Edanami, Naoki Yoshiba, Kunihiko Shirakashi, Mari Ibn Belal, Razi Saifullah Yoshiba, Nagako Ohkura, Naoto Tohma, Aiko Takeuchi, Ryosuke Okiji, Takashi Noiri, Yuichiro |
| description | When regenerative endodontic procedures (REPs) are performed on immature teeth diagnosed with pulp necrosis and apical periodontitis, various healing patterns occur. Furthermore, infected immature teeth with endodontic disorders often exhibit some remnant pulp and apical tissue. Therefore, this study investigated the impact of remnant healthy or fully functional pulp and apical tissue on healing patterns after REPs. Simulated REPs were performed on non-infected immature rat molars with different amounts of remnant pulp and apical tissue. Healing patterns in these teeth were assessed after 28 days. Teeth with 0.81–0.91 mm of remnant pulp healed with pulp-like tissue, dentin, and osteodentin-like dentin-associated mineralized tissue (OSD-DAMT); teeth with 0.60–0.63 mm of remnant pulp healed with pulp-like tissue and OSD-DAMT; teeth with 0.13–0.43 mm of remnant pulp healed with periodontal ligament (PDL)-like tissue, OSD-DAMT, and cementum-like dentin-associated mineralized tissue (CEM-DAMT); and teeth with disorganization of pulp and apical tissues at 0.15–0.38 mm beyond the root apex healed with PDL-like tissue, CEM-DAMT, and intracanal bone (IB). Loss of Hertwig’s epithelial root sheath was observed with IB formation. These results showed that four distinct healing patterns occurred after REPs, depending on the preoperative amount of remnant healthy pulp and apical tissue. |
| doi_str_mv | 10.1038/s41598-020-78022-w |
| format | Article |
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Furthermore, infected immature teeth with endodontic disorders often exhibit some remnant pulp and apical tissue. Therefore, this study investigated the impact of remnant healthy or fully functional pulp and apical tissue on healing patterns after REPs. Simulated REPs were performed on non-infected immature rat molars with different amounts of remnant pulp and apical tissue. Healing patterns in these teeth were assessed after 28 days. Teeth with 0.81–0.91 mm of remnant pulp healed with pulp-like tissue, dentin, and osteodentin-like dentin-associated mineralized tissue (OSD-DAMT); teeth with 0.60–0.63 mm of remnant pulp healed with pulp-like tissue and OSD-DAMT; teeth with 0.13–0.43 mm of remnant pulp healed with periodontal ligament (PDL)-like tissue, OSD-DAMT, and cementum-like dentin-associated mineralized tissue (CEM-DAMT); and teeth with disorganization of pulp and apical tissues at 0.15–0.38 mm beyond the root apex healed with PDL-like tissue, CEM-DAMT, and intracanal bone (IB). Loss of Hertwig’s epithelial root sheath was observed with IB formation. These results showed that four distinct healing patterns occurred after REPs, depending on the preoperative amount of remnant healthy pulp and apical tissue.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-78022-w</identifier><identifier>PMID: 33262423</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/45/880/1257 ; 692/699/3017 ; Animals ; Cementum ; Dental pulp ; Dental Pulp - diagnostic imaging ; Dental Pulp - physiology ; Dentin ; Humanities and Social Sciences ; Molar - diagnostic imaging ; Molar - physiology ; Molars ; multidisciplinary ; Periodontal ligament ; Periodontitis ; Rats ; Regenerative Endodontics ; Science ; Science (multidisciplinary) ; Teeth ; Tissues ; Tooth Apex - diagnostic imaging ; Tooth Apex - physiology ; X-Ray Microtomography</subject><ispartof>Scientific reports, 2020-12, Vol.10 (1), p.20967-20967, Article 20967</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-a0f5e7fcaebeb119523c67589720b2390cdc8187d14484e2e9425f75443208a13</citedby><cites>FETCH-LOGICAL-c540t-a0f5e7fcaebeb119523c67589720b2390cdc8187d14484e2e9425f75443208a13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708843/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708843/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33262423$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Edanami, Naoki</creatorcontrib><creatorcontrib>Yoshiba, Kunihiko</creatorcontrib><creatorcontrib>Shirakashi, Mari</creatorcontrib><creatorcontrib>Ibn Belal, Razi Saifullah</creatorcontrib><creatorcontrib>Yoshiba, Nagako</creatorcontrib><creatorcontrib>Ohkura, Naoto</creatorcontrib><creatorcontrib>Tohma, Aiko</creatorcontrib><creatorcontrib>Takeuchi, Ryosuke</creatorcontrib><creatorcontrib>Okiji, Takashi</creatorcontrib><creatorcontrib>Noiri, Yuichiro</creatorcontrib><title>Impact of remnant healthy pulp and apical tissue on outcomes after simulated regenerative endodontic procedure in rat molars</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>When regenerative endodontic procedures (REPs) are performed on immature teeth diagnosed with pulp necrosis and apical periodontitis, various healing patterns occur. Furthermore, infected immature teeth with endodontic disorders often exhibit some remnant pulp and apical tissue. Therefore, this study investigated the impact of remnant healthy or fully functional pulp and apical tissue on healing patterns after REPs. Simulated REPs were performed on non-infected immature rat molars with different amounts of remnant pulp and apical tissue. Healing patterns in these teeth were assessed after 28 days. Teeth with 0.81–0.91 mm of remnant pulp healed with pulp-like tissue, dentin, and osteodentin-like dentin-associated mineralized tissue (OSD-DAMT); teeth with 0.60–0.63 mm of remnant pulp healed with pulp-like tissue and OSD-DAMT; teeth with 0.13–0.43 mm of remnant pulp healed with periodontal ligament (PDL)-like tissue, OSD-DAMT, and cementum-like dentin-associated mineralized tissue (CEM-DAMT); and teeth with disorganization of pulp and apical tissues at 0.15–0.38 mm beyond the root apex healed with PDL-like tissue, CEM-DAMT, and intracanal bone (IB). Loss of Hertwig’s epithelial root sheath was observed with IB formation. These results showed that four distinct healing patterns occurred after REPs, depending on the preoperative amount of remnant healthy pulp and apical tissue.</description><subject>631/45/880/1257</subject><subject>692/699/3017</subject><subject>Animals</subject><subject>Cementum</subject><subject>Dental pulp</subject><subject>Dental Pulp - diagnostic imaging</subject><subject>Dental Pulp - physiology</subject><subject>Dentin</subject><subject>Humanities and Social Sciences</subject><subject>Molar - diagnostic imaging</subject><subject>Molar - physiology</subject><subject>Molars</subject><subject>multidisciplinary</subject><subject>Periodontal ligament</subject><subject>Periodontitis</subject><subject>Rats</subject><subject>Regenerative Endodontics</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Teeth</subject><subject>Tissues</subject><subject>Tooth Apex - diagnostic imaging</subject><subject>Tooth Apex - physiology</subject><subject>X-Ray Microtomography</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kUFrFTEQx4MotrT9Ah4k4MXL1mSS3WQvghRtCwUv9RzysrPvpewma5JtKfjhTX21Vg_mksD85j8ZfoS84eyUM6E_ZMnbXjcMWKM0A2juXpBDYLJtQAC8fPY-ICc537B6Wugl71-TAyGgAwnikPy4nBfrCo0jTTgHGwrdoZ3K7p4u67RQGwZqF-_sRIvPeUUaA41rcXHGTO1YMNHs53WyBYcascWAyRZ_ixTDEIcYind0SdHhsCakPtBapnOcbMrH5NVop4wnj_cR-fbl8_XZRXP19fzy7NNV41rJSmPZ2KIancUNbjjvWxCuU63uFbANiJ65wWmu1cCl1BIBewntqFopBTBtuTgiH_e5y7qZcXAYSrKTWZKfbbo30XrzdyX4ndnGW6MU01qKGvD-MSDF7yvmYmafHU6TDRjXbEB2HfSdFn1F3_2D3sQ1hbpepZQAxauFSsGecinmnHB8-gxn5sGv2fs11a_55dfc1aa3z9d4avltswJiD-RaCltMf2b_J_YntnuzUg</recordid><startdate>20201201</startdate><enddate>20201201</enddate><creator>Edanami, Naoki</creator><creator>Yoshiba, Kunihiko</creator><creator>Shirakashi, Mari</creator><creator>Ibn Belal, Razi Saifullah</creator><creator>Yoshiba, Nagako</creator><creator>Ohkura, Naoto</creator><creator>Tohma, Aiko</creator><creator>Takeuchi, Ryosuke</creator><creator>Okiji, Takashi</creator><creator>Noiri, Yuichiro</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20201201</creationdate><title>Impact of remnant healthy pulp and apical tissue on outcomes after simulated regenerative endodontic procedure in rat molars</title><author>Edanami, Naoki ; Yoshiba, Kunihiko ; Shirakashi, Mari ; Ibn Belal, Razi Saifullah ; Yoshiba, Nagako ; Ohkura, Naoto ; Tohma, Aiko ; Takeuchi, Ryosuke ; Okiji, Takashi ; Noiri, Yuichiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-a0f5e7fcaebeb119523c67589720b2390cdc8187d14484e2e9425f75443208a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>631/45/880/1257</topic><topic>692/699/3017</topic><topic>Animals</topic><topic>Cementum</topic><topic>Dental pulp</topic><topic>Dental Pulp - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Edanami, Naoki</au><au>Yoshiba, Kunihiko</au><au>Shirakashi, Mari</au><au>Ibn Belal, Razi Saifullah</au><au>Yoshiba, Nagako</au><au>Ohkura, Naoto</au><au>Tohma, Aiko</au><au>Takeuchi, Ryosuke</au><au>Okiji, Takashi</au><au>Noiri, Yuichiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of remnant healthy pulp and apical tissue on outcomes after simulated regenerative endodontic procedure in rat molars</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-12-01</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>20967</spage><epage>20967</epage><pages>20967-20967</pages><artnum>20967</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>When regenerative endodontic procedures (REPs) are performed on immature teeth diagnosed with pulp necrosis and apical periodontitis, various healing patterns occur. Furthermore, infected immature teeth with endodontic disorders often exhibit some remnant pulp and apical tissue. Therefore, this study investigated the impact of remnant healthy or fully functional pulp and apical tissue on healing patterns after REPs. Simulated REPs were performed on non-infected immature rat molars with different amounts of remnant pulp and apical tissue. Healing patterns in these teeth were assessed after 28 days. Teeth with 0.81–0.91 mm of remnant pulp healed with pulp-like tissue, dentin, and osteodentin-like dentin-associated mineralized tissue (OSD-DAMT); teeth with 0.60–0.63 mm of remnant pulp healed with pulp-like tissue and OSD-DAMT; teeth with 0.13–0.43 mm of remnant pulp healed with periodontal ligament (PDL)-like tissue, OSD-DAMT, and cementum-like dentin-associated mineralized tissue (CEM-DAMT); and teeth with disorganization of pulp and apical tissues at 0.15–0.38 mm beyond the root apex healed with PDL-like tissue, CEM-DAMT, and intracanal bone (IB). Loss of Hertwig’s epithelial root sheath was observed with IB formation. These results showed that four distinct healing patterns occurred after REPs, depending on the preoperative amount of remnant healthy pulp and apical tissue.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33262423</pmid><doi>10.1038/s41598-020-78022-w</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/45/880/1257 692/699/3017 Animals Cementum Dental pulp Dental Pulp - diagnostic imaging Dental Pulp - physiology Dentin Humanities and Social Sciences Molar - diagnostic imaging Molar - physiology Molars multidisciplinary Periodontal ligament Periodontitis Rats Regenerative Endodontics Science Science (multidisciplinary) Teeth Tissues Tooth Apex - diagnostic imaging Tooth Apex - physiology X-Ray Microtomography |
| title | Impact of remnant healthy pulp and apical tissue on outcomes after simulated regenerative endodontic procedure in rat molars |
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