Vitamin D3 and erythropoietin protect against renal ischemia-reperfusion injury via heat shock protein 70 and microRNA-21 expression

Kidney ischemia reperfusion (IR) contributes to the development of acute kidney injury. The hypoxic conditions in ischemic damage lead to oxidative stress and apoptotic cell death. We investigated the effects of vitamin D3 (Vit D) and erythropoietin (EPO) on microRNA-21(miR-21) expression in renal I...

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Veröffentlicht in:	Scientific reports 2020-12, Vol.10 (1), p.20906-20906, Article 20906
Hauptverfasser:	Golmohammadi, Mohammad Ghasem, Banaei, Shokofeh, Nejati, Kazem, Chinifroush-Asl, Mir Mehdi
Format:	Artikel
Sprache:	eng
Schlagworte:	631/443 692/4022 Animals Apoptosis Blood Urea Nitrogen Caspase-3 Cell death Cholecalciferol - pharmacology Erythropoietin Erythropoietin - pharmacology Heat shock proteins HSP70 Heat-Shock Proteins - metabolism Hsp70 protein Humanities and Social Sciences Hypoxia Ischemia Kidney - blood supply Kidney - metabolism Kidney Glomerulus - pathology Kidney Tubules - pathology Kidneys MicroRNAs MicroRNAs - metabolism miRNA multidisciplinary Occlusion Oxidative stress Rats Rats, Wistar Reperfusion Reperfusion Injury - metabolism Reperfusion Injury - prevention & control Science Science (multidisciplinary) Urea Vitamin D Vitamin D3
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