Investigating the pharmacodynamic durability of GalNAc–siRNA conjugates

Abstract One hallmark of trivalent N-acetylgalactosamine (GalNAc)-conjugated siRNAs is the remarkable durability of silencing that can persist for months in preclinical species and humans. Here, we investigated the underlying biology supporting this extended duration of pharmacological activity. We...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nucleic acids research 2020-12, Vol.48 (21), p.11827-11844
Hauptverfasser:	Brown, Christopher R, Gupta, Swati, Qin, June, Racie, Timothy, He, Guo, Lentini, Scott, Malone, Ryan, Yu, Mikyung, Matsuda, Shigeo, Shulga-Morskaya, Svetlana, Nair, Anil V, Theile, Christopher S, Schmidt, Karyn, Shahraz, Azar, Goel, Varun, Parmar, Rubina G, Zlatev, Ivan, Schlegel, Mark K, Nair, Jayaprakash K, Jayaraman, Muthusamy, Manoharan, Muthiah, Brown, Dennis, Maier, Martin A, Jadhav, Vasant
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylgalactosamine - chemistry Acetylgalactosamine - metabolism Animals Argonaute Proteins - genetics Asialoglycoprotein Receptor - genetics Asialoglycoprotein Receptor - metabolism Biological Transport Drug Carriers Drug Stability Female Gene Silencing Glycoconjugates - chemistry Glycoconjugates - metabolism Hepatocytes - cytology Hepatocytes - metabolism Humans Hydrogen-Ion Concentration Liver - cytology Liver - metabolism Mice Mice, Inbred C57BL Nanoparticles - chemistry Nanoparticles - metabolism NAR Breakthrough Prealbumin - antagonists & inhibitors Prealbumin - genetics Prealbumin - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Time Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!