Hallucinations Under Psychedelics and in the Schizophrenia Spectrum: An Interdisciplinary and Multiscale Comparison
Abstract The recent renaissance of psychedelic science has reignited interest in the similarity of drug-induced experiences to those more commonly observed in psychiatric contexts such as the schizophrenia-spectrum. This report from a multidisciplinary working group of the International Consortium o...
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| Veröffentlicht in: | Schizophrenia bulletin 2020-12, Vol.46 (6), p.1396-1408 |
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| container_title | Schizophrenia bulletin |
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| creator | Leptourgos, Pantelis Fortier-Davy, Martin Carhart-Harris, Robin Corlett, Philip R Dupuis, David Halberstadt, Adam L Kometer, Michael Kozakova, Eva LarØi, Frank Noorani, Tehseen N Preller, Katrin H Waters, Flavie Zaytseva, Yuliya Jardri, Renaud |
| description | Abstract
The recent renaissance of psychedelic science has reignited interest in the similarity of drug-induced experiences to those more commonly observed in psychiatric contexts such as the schizophrenia-spectrum. This report from a multidisciplinary working group of the International Consortium on Hallucinations Research (ICHR) addresses this issue, putting special emphasis on hallucinatory experiences. We review evidence collected at different scales of understanding, from pharmacology to brain-imaging, phenomenology and anthropology, highlighting similarities and differences between hallucinations under psychedelics and in the schizophrenia-spectrum disorders. Finally, we attempt to integrate these findings using computational approaches and conclude with recommendations for future research. |
| doi_str_mv | 10.1093/schbul/sbaa117 |
| format | Article |
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The recent renaissance of psychedelic science has reignited interest in the similarity of drug-induced experiences to those more commonly observed in psychiatric contexts such as the schizophrenia-spectrum. This report from a multidisciplinary working group of the International Consortium on Hallucinations Research (ICHR) addresses this issue, putting special emphasis on hallucinatory experiences. We review evidence collected at different scales of understanding, from pharmacology to brain-imaging, phenomenology and anthropology, highlighting similarities and differences between hallucinations under psychedelics and in the schizophrenia-spectrum disorders. Finally, we attempt to integrate these findings using computational approaches and conclude with recommendations for future research.</description><identifier>ISSN: 0586-7614</identifier><identifier>EISSN: 1745-1701</identifier><identifier>DOI: 10.1093/schbul/sbaa117</identifier><identifier>PMID: 32944778</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Bayesian ; computational ; hallucinations ; Hallucinations - chemically induced ; Hallucinations - diagnostic imaging ; Hallucinations - etiology ; Hallucinations - physiopathology ; Hallucinogens ; Hallucinogens - adverse effects ; Humans ; Nerve Net ; Nerve Net - diagnostic imaging ; Nerve Net - drug effects ; Nerve Net - physiopathology ; Neurosciences & behavior ; Neurosciences & comportement ; psychedelics ; Psychiatry and Mental Health ; psychosis ; Schizophrenia ; Schizophrenia - complications ; Schizophrenia - diagnostic imaging ; Schizophrenia - physiopathology ; Sciences sociales & comportementales, psychologie ; serotonin ; Social & behavioral sciences, psychology ; Theme: Hallucinations Research in a Time of Crisis</subject><ispartof>Schizophrenia bulletin, 2020-12, Vol.46 (6), p.1396-1408</ispartof><rights>The Author(s) 2020. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. 2020</rights><rights>The Author(s) 2020. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.</rights><rights>info:eu-repo/semantics/openAccess</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c492t-1b2f8bd8556f51e9a4e38b293b7d3b466f400e564672d66f6541392b6f8f25423</citedby><cites>FETCH-LOGICAL-c492t-1b2f8bd8556f51e9a4e38b293b7d3b466f400e564672d66f6541392b6f8f25423</cites><orcidid>0000-0002-2491-0768 ; 0000-0002-0801-5501 ; 0000-0003-4596-1502 ; 0000-0002-4185-0218</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7707069/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7707069/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,1584,26567,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32944778$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leptourgos, Pantelis</creatorcontrib><creatorcontrib>Fortier-Davy, Martin</creatorcontrib><creatorcontrib>Carhart-Harris, Robin</creatorcontrib><creatorcontrib>Corlett, Philip R</creatorcontrib><creatorcontrib>Dupuis, David</creatorcontrib><creatorcontrib>Halberstadt, Adam L</creatorcontrib><creatorcontrib>Kometer, Michael</creatorcontrib><creatorcontrib>Kozakova, Eva</creatorcontrib><creatorcontrib>LarØi, Frank</creatorcontrib><creatorcontrib>Noorani, Tehseen N</creatorcontrib><creatorcontrib>Preller, Katrin H</creatorcontrib><creatorcontrib>Waters, Flavie</creatorcontrib><creatorcontrib>Zaytseva, Yuliya</creatorcontrib><creatorcontrib>Jardri, Renaud</creatorcontrib><title>Hallucinations Under Psychedelics and in the Schizophrenia Spectrum: An Interdisciplinary and Multiscale Comparison</title><title>Schizophrenia bulletin</title><addtitle>Schizophr Bull</addtitle><description>Abstract
The recent renaissance of psychedelic science has reignited interest in the similarity of drug-induced experiences to those more commonly observed in psychiatric contexts such as the schizophrenia-spectrum. This report from a multidisciplinary working group of the International Consortium on Hallucinations Research (ICHR) addresses this issue, putting special emphasis on hallucinatory experiences. We review evidence collected at different scales of understanding, from pharmacology to brain-imaging, phenomenology and anthropology, highlighting similarities and differences between hallucinations under psychedelics and in the schizophrenia-spectrum disorders. Finally, we attempt to integrate these findings using computational approaches and conclude with recommendations for future research.</description><subject>Bayesian</subject><subject>computational</subject><subject>hallucinations</subject><subject>Hallucinations - chemically induced</subject><subject>Hallucinations - diagnostic imaging</subject><subject>Hallucinations - etiology</subject><subject>Hallucinations - physiopathology</subject><subject>Hallucinogens</subject><subject>Hallucinogens - adverse effects</subject><subject>Humans</subject><subject>Nerve Net</subject><subject>Nerve Net - diagnostic imaging</subject><subject>Nerve Net - drug effects</subject><subject>Nerve Net - physiopathology</subject><subject>Neurosciences & behavior</subject><subject>Neurosciences & comportement</subject><subject>psychedelics</subject><subject>Psychiatry and Mental Health</subject><subject>psychosis</subject><subject>Schizophrenia</subject><subject>Schizophrenia - complications</subject><subject>Schizophrenia - diagnostic imaging</subject><subject>Schizophrenia - physiopathology</subject><subject>Sciences sociales & comportementales, psychologie</subject><subject>serotonin</subject><subject>Social & behavioral sciences, psychology</subject><subject>Theme: Hallucinations Research in a Time of Crisis</subject><issn>0586-7614</issn><issn>1745-1701</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><sourceid>EIF</sourceid><sourceid>3HK</sourceid><recordid>eNqFks1v1DAQxSMEokvhyhFypIe0tuOPhANStSq0UhFIpWfLdiYbI8cOdlKp_PW4m20FJ062x-_99MaeoniL0SlGbX2WzKAXd5a0UhiLZ8UGC8oqLBB-XmwQa3glOKZHxauUfiKEacvJy-KoJi2lQjSbIl0q5xZjvZpt8Km89R3E8nu6NwN04KxJpfJdaX05D1DemMH-DtMQwVtV3kxg5riMH8tzX175GWJnk7GTy7R4v_d9Xdyca8pBuQ3jpKJNwb8uXvTKJXhzWI-L288XP7aX1fW3L1fb8-vK0JbMFdakb3TXMMZ7hqFVFOpGk7bWoqs15bynCAHjlAvS5RNnFNct0bxvesIoqY-LTyt3WvQInQE_R-XkFO2Y88mgrPz3xttB7sKdFAIJxNsMqFeAs7ADGaK28o7sjfv94nZSGalBEsIbSVrMMMqu96vL5G5n66UPUUmMGkZkw7B44H44BIvh1wJplmN-JHBOeQhLkoRSWje4ZTxLTx9hIaUI_VN8jOTDBMh1AuRhArLh3d9NP8kfvzwLTlZBWKb_wf4AE8W93w</recordid><startdate>20201201</startdate><enddate>20201201</enddate><creator>Leptourgos, Pantelis</creator><creator>Fortier-Davy, Martin</creator><creator>Carhart-Harris, Robin</creator><creator>Corlett, Philip R</creator><creator>Dupuis, David</creator><creator>Halberstadt, Adam L</creator><creator>Kometer, Michael</creator><creator>Kozakova, Eva</creator><creator>LarØi, Frank</creator><creator>Noorani, Tehseen N</creator><creator>Preller, Katrin H</creator><creator>Waters, Flavie</creator><creator>Zaytseva, Yuliya</creator><creator>Jardri, Renaud</creator><general>Oxford University Press</general><scope>TOX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>3HK</scope><scope>Q33</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2491-0768</orcidid><orcidid>https://orcid.org/0000-0002-0801-5501</orcidid><orcidid>https://orcid.org/0000-0003-4596-1502</orcidid><orcidid>https://orcid.org/0000-0002-4185-0218</orcidid></search><sort><creationdate>20201201</creationdate><title>Hallucinations Under Psychedelics and in the Schizophrenia Spectrum: An Interdisciplinary and Multiscale Comparison</title><author>Leptourgos, Pantelis ; Fortier-Davy, Martin ; Carhart-Harris, Robin ; Corlett, Philip R ; Dupuis, David ; Halberstadt, Adam L ; Kometer, Michael ; Kozakova, Eva ; LarØi, Frank ; Noorani, Tehseen N ; Preller, Katrin H ; Waters, Flavie ; Zaytseva, Yuliya ; Jardri, Renaud</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c492t-1b2f8bd8556f51e9a4e38b293b7d3b466f400e564672d66f6541392b6f8f25423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Bayesian</topic><topic>computational</topic><topic>hallucinations</topic><topic>Hallucinations - chemically induced</topic><topic>Hallucinations - diagnostic imaging</topic><topic>Hallucinations - etiology</topic><topic>Hallucinations - physiopathology</topic><topic>Hallucinogens</topic><topic>Hallucinogens - adverse effects</topic><topic>Humans</topic><topic>Nerve Net</topic><topic>Nerve Net - diagnostic imaging</topic><topic>Nerve Net - drug effects</topic><topic>Nerve Net - physiopathology</topic><topic>Neurosciences & behavior</topic><topic>Neurosciences & comportement</topic><topic>psychedelics</topic><topic>Psychiatry and Mental Health</topic><topic>psychosis</topic><topic>Schizophrenia</topic><topic>Schizophrenia - complications</topic><topic>Schizophrenia - diagnostic imaging</topic><topic>Schizophrenia - physiopathology</topic><topic>Sciences sociales & comportementales, psychologie</topic><topic>serotonin</topic><topic>Social & behavioral sciences, psychology</topic><topic>Theme: Hallucinations Research in a Time of Crisis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leptourgos, Pantelis</creatorcontrib><creatorcontrib>Fortier-Davy, Martin</creatorcontrib><creatorcontrib>Carhart-Harris, Robin</creatorcontrib><creatorcontrib>Corlett, Philip R</creatorcontrib><creatorcontrib>Dupuis, David</creatorcontrib><creatorcontrib>Halberstadt, Adam L</creatorcontrib><creatorcontrib>Kometer, Michael</creatorcontrib><creatorcontrib>Kozakova, Eva</creatorcontrib><creatorcontrib>LarØi, Frank</creatorcontrib><creatorcontrib>Noorani, Tehseen N</creatorcontrib><creatorcontrib>Preller, Katrin H</creatorcontrib><creatorcontrib>Waters, Flavie</creatorcontrib><creatorcontrib>Zaytseva, Yuliya</creatorcontrib><creatorcontrib>Jardri, Renaud</creatorcontrib><collection>Oxford Journals Open Access Collection</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>NORA - Norwegian Open Research Archives</collection><collection>Université de Liège - Open Repository and Bibliography (ORBI)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Schizophrenia bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leptourgos, Pantelis</au><au>Fortier-Davy, Martin</au><au>Carhart-Harris, Robin</au><au>Corlett, Philip R</au><au>Dupuis, David</au><au>Halberstadt, Adam L</au><au>Kometer, Michael</au><au>Kozakova, Eva</au><au>LarØi, Frank</au><au>Noorani, Tehseen N</au><au>Preller, Katrin H</au><au>Waters, Flavie</au><au>Zaytseva, Yuliya</au><au>Jardri, Renaud</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hallucinations Under Psychedelics and in the Schizophrenia Spectrum: An Interdisciplinary and Multiscale Comparison</atitle><jtitle>Schizophrenia bulletin</jtitle><addtitle>Schizophr Bull</addtitle><date>2020-12-01</date><risdate>2020</risdate><volume>46</volume><issue>6</issue><spage>1396</spage><epage>1408</epage><pages>1396-1408</pages><issn>0586-7614</issn><eissn>1745-1701</eissn><abstract>Abstract
The recent renaissance of psychedelic science has reignited interest in the similarity of drug-induced experiences to those more commonly observed in psychiatric contexts such as the schizophrenia-spectrum. This report from a multidisciplinary working group of the International Consortium on Hallucinations Research (ICHR) addresses this issue, putting special emphasis on hallucinatory experiences. We review evidence collected at different scales of understanding, from pharmacology to brain-imaging, phenomenology and anthropology, highlighting similarities and differences between hallucinations under psychedelics and in the schizophrenia-spectrum disorders. Finally, we attempt to integrate these findings using computational approaches and conclude with recommendations for future research.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>32944778</pmid><doi>10.1093/schbul/sbaa117</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-2491-0768</orcidid><orcidid>https://orcid.org/0000-0002-0801-5501</orcidid><orcidid>https://orcid.org/0000-0003-4596-1502</orcidid><orcidid>https://orcid.org/0000-0002-4185-0218</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; NORA - Norwegian Open Research Archives; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Bayesian computational hallucinations Hallucinations - chemically induced Hallucinations - diagnostic imaging Hallucinations - etiology Hallucinations - physiopathology Hallucinogens Hallucinogens - adverse effects Humans Nerve Net Nerve Net - diagnostic imaging Nerve Net - drug effects Nerve Net - physiopathology Neurosciences & behavior Neurosciences & comportement psychedelics Psychiatry and Mental Health psychosis Schizophrenia Schizophrenia - complications Schizophrenia - diagnostic imaging Schizophrenia - physiopathology Sciences sociales & comportementales, psychologie serotonin Social & behavioral sciences, psychology Theme: Hallucinations Research in a Time of Crisis |
| title | Hallucinations Under Psychedelics and in the Schizophrenia Spectrum: An Interdisciplinary and Multiscale Comparison |
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