Characterizing the role of tissue-type plasminogen activator in a mouse model of Group A streptococcal infection
Plasmin(ogen) acquisition is critical for invasive disease initiation by Streptococcus pyogenes (GAS). Host urokinase plasminogen activator (uPA) plays a role in mediating plasminogen activation for GAS dissemination, however the contribution of tissue-type plasminogen activator (tPA) to GAS virulen...
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| Veröffentlicht in: | Microbes and infection 2019-10, Vol.21 (8-9), p.412-417 |
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| container_issue | 8-9 |
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| container_title | Microbes and infection |
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| creator | Ly, Diane Donahue, Deborah Walker, Mark J. Ploplis, Victoria A. McArthur, Jason D. Ranson, Marie Castellino, Francis J. Sanderson-Smith, Martina L. |
| description | Plasmin(ogen) acquisition is critical for invasive disease initiation by Streptococcus pyogenes (GAS). Host urokinase plasminogen activator (uPA) plays a role in mediating plasminogen activation for GAS dissemination, however the contribution of tissue-type plasminogen activator (tPA) to GAS virulence is unknown. Using novel tPA-deficient ALBPLG1 mice, our study revealed no difference in mouse survival, bacterial dissemination or the pathology of GAS infection in the absence of tPA in AlbPLG1/tPA−/− mice compared to AlbPLG1 mice. This study suggests that tPA has a limited role in this humanized model of GAS infection, further highlighting the importance of its counterpart uPA in GAS disease. |
| doi_str_mv | 10.1016/j.micinf.2019.04.004 |
| format | Article |
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Host urokinase plasminogen activator (uPA) plays a role in mediating plasminogen activation for GAS dissemination, however the contribution of tissue-type plasminogen activator (tPA) to GAS virulence is unknown. Using novel tPA-deficient ALBPLG1 mice, our study revealed no difference in mouse survival, bacterial dissemination or the pathology of GAS infection in the absence of tPA in AlbPLG1/tPA−/− mice compared to AlbPLG1 mice. This study suggests that tPA has a limited role in this humanized model of GAS infection, further highlighting the importance of its counterpart uPA in GAS disease.</description><identifier>ISSN: 1286-4579</identifier><identifier>EISSN: 1769-714X</identifier><identifier>DOI: 10.1016/j.micinf.2019.04.004</identifier><identifier>PMID: 31009808</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Animal infection model ; Animals ; Bacterial Load ; Disease Models, Animal ; Mice ; Mice, Mutant Strains ; Mice, Transgenic ; Microbial Viability ; Mutation ; Plasminogen ; Streptococcal Infections - microbiology ; Streptococcal Infections - pathology ; Streptococcus pyogenes ; Streptococcus pyogenes - pathogenicity ; Streptokinase ; Tissue Plasminogen Activator - genetics ; Tissue Plasminogen Activator - metabolism ; Tissue-type plasminogen activator (tPA) ; Urokinase plasminogen activator (uPA) ; Virulence</subject><ispartof>Microbes and infection, 2019-10, Vol.21 (8-9), p.412-417</ispartof><rights>2019 Institut Pasteur</rights><rights>Copyright © 2019 Institut Pasteur. 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All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c463t-c21f5fe9b66962626e5443584faad234e0a750b9a2d6910f410486cc6370de893</citedby><cites>FETCH-LOGICAL-c463t-c21f5fe9b66962626e5443584faad234e0a750b9a2d6910f410486cc6370de893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.micinf.2019.04.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31009808$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ly, Diane</creatorcontrib><creatorcontrib>Donahue, Deborah</creatorcontrib><creatorcontrib>Walker, Mark J.</creatorcontrib><creatorcontrib>Ploplis, Victoria A.</creatorcontrib><creatorcontrib>McArthur, Jason D.</creatorcontrib><creatorcontrib>Ranson, Marie</creatorcontrib><creatorcontrib>Castellino, Francis J.</creatorcontrib><creatorcontrib>Sanderson-Smith, Martina L.</creatorcontrib><title>Characterizing the role of tissue-type plasminogen activator in a mouse model of Group A streptococcal infection</title><title>Microbes and infection</title><addtitle>Microbes Infect</addtitle><description>Plasmin(ogen) acquisition is critical for invasive disease initiation by Streptococcus pyogenes (GAS). Host urokinase plasminogen activator (uPA) plays a role in mediating plasminogen activation for GAS dissemination, however the contribution of tissue-type plasminogen activator (tPA) to GAS virulence is unknown. Using novel tPA-deficient ALBPLG1 mice, our study revealed no difference in mouse survival, bacterial dissemination or the pathology of GAS infection in the absence of tPA in AlbPLG1/tPA−/− mice compared to AlbPLG1 mice. This study suggests that tPA has a limited role in this humanized model of GAS infection, further highlighting the importance of its counterpart uPA in GAS disease.</description><subject>Animal infection model</subject><subject>Animals</subject><subject>Bacterial Load</subject><subject>Disease Models, Animal</subject><subject>Mice</subject><subject>Mice, Mutant Strains</subject><subject>Mice, Transgenic</subject><subject>Microbial Viability</subject><subject>Mutation</subject><subject>Plasminogen</subject><subject>Streptococcal Infections - microbiology</subject><subject>Streptococcal Infections - pathology</subject><subject>Streptococcus pyogenes</subject><subject>Streptococcus pyogenes - pathogenicity</subject><subject>Streptokinase</subject><subject>Tissue Plasminogen Activator - genetics</subject><subject>Tissue Plasminogen Activator - metabolism</subject><subject>Tissue-type plasminogen activator (tPA)</subject><subject>Urokinase plasminogen activator (uPA)</subject><subject>Virulence</subject><issn>1286-4579</issn><issn>1769-714X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UV2L1DAULaK46-o_EMmjL603bZo0L8Iy6K6w4IuCbyGT3sxkaJOapAPrrzfD7K76IoF8kHPOvfecqnpLoaFA-YdDMzvjvG1aoLIB1gCwZ9UlFVzWgrIfz8u9HXjNeiEvqlcpHQBoLzh7WV10FEAOMFxWy2avozYZo_vl_I7kPZIYJiTBkuxSWrHO9wuSZdJpdj7s0JMCd0edQySuPMgc1oRlH3E6sW5iWBdyTVKOuORggjF6KkiLhRb86-qF1VPCNw_nVfX986dvm9v67uvNl831XW0Y73JtWmp7i3LLueRtWdgz1vUDs1qPbccQtOhhK3U7cknBMgps4MbwTsCIg-yuqo9n3WXdzjga9DnqSS3RzTreq6Cd-vfHu73ahaMSAkRxqgi8fxCI4eeKKavZJYPTpD2WiVXb0o6WpnooUHaGmhhSimifylBQp7DUQZ3DUqewFDBVwiq0d3-3-ER6TOfPDFiMOjqMKhmH3uDoYnFTjcH9v8JvIuSqBw</recordid><startdate>20191001</startdate><enddate>20191001</enddate><creator>Ly, Diane</creator><creator>Donahue, Deborah</creator><creator>Walker, Mark J.</creator><creator>Ploplis, Victoria A.</creator><creator>McArthur, Jason D.</creator><creator>Ranson, Marie</creator><creator>Castellino, Francis J.</creator><creator>Sanderson-Smith, Martina L.</creator><general>Elsevier Masson SAS</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20191001</creationdate><title>Characterizing the role of tissue-type plasminogen activator in a mouse model of Group A streptococcal infection</title><author>Ly, Diane ; Donahue, Deborah ; Walker, Mark J. ; Ploplis, Victoria A. ; McArthur, Jason D. ; Ranson, Marie ; Castellino, Francis J. ; Sanderson-Smith, Martina L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c463t-c21f5fe9b66962626e5443584faad234e0a750b9a2d6910f410486cc6370de893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animal infection model</topic><topic>Animals</topic><topic>Bacterial Load</topic><topic>Disease Models, Animal</topic><topic>Mice</topic><topic>Mice, Mutant Strains</topic><topic>Mice, Transgenic</topic><topic>Microbial Viability</topic><topic>Mutation</topic><topic>Plasminogen</topic><topic>Streptococcal Infections - microbiology</topic><topic>Streptococcal Infections - pathology</topic><topic>Streptococcus pyogenes</topic><topic>Streptococcus pyogenes - pathogenicity</topic><topic>Streptokinase</topic><topic>Tissue Plasminogen Activator - genetics</topic><topic>Tissue Plasminogen Activator - metabolism</topic><topic>Tissue-type plasminogen activator (tPA)</topic><topic>Urokinase plasminogen activator (uPA)</topic><topic>Virulence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ly, Diane</creatorcontrib><creatorcontrib>Donahue, Deborah</creatorcontrib><creatorcontrib>Walker, Mark J.</creatorcontrib><creatorcontrib>Ploplis, Victoria A.</creatorcontrib><creatorcontrib>McArthur, Jason D.</creatorcontrib><creatorcontrib>Ranson, Marie</creatorcontrib><creatorcontrib>Castellino, Francis J.</creatorcontrib><creatorcontrib>Sanderson-Smith, Martina L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Microbes and infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ly, Diane</au><au>Donahue, Deborah</au><au>Walker, Mark J.</au><au>Ploplis, Victoria A.</au><au>McArthur, Jason D.</au><au>Ranson, Marie</au><au>Castellino, Francis J.</au><au>Sanderson-Smith, Martina L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterizing the role of tissue-type plasminogen activator in a mouse model of Group A streptococcal infection</atitle><jtitle>Microbes and infection</jtitle><addtitle>Microbes Infect</addtitle><date>2019-10-01</date><risdate>2019</risdate><volume>21</volume><issue>8-9</issue><spage>412</spage><epage>417</epage><pages>412-417</pages><issn>1286-4579</issn><eissn>1769-714X</eissn><abstract>Plasmin(ogen) acquisition is critical for invasive disease initiation by Streptococcus pyogenes (GAS). Host urokinase plasminogen activator (uPA) plays a role in mediating plasminogen activation for GAS dissemination, however the contribution of tissue-type plasminogen activator (tPA) to GAS virulence is unknown. Using novel tPA-deficient ALBPLG1 mice, our study revealed no difference in mouse survival, bacterial dissemination or the pathology of GAS infection in the absence of tPA in AlbPLG1/tPA−/− mice compared to AlbPLG1 mice. This study suggests that tPA has a limited role in this humanized model of GAS infection, further highlighting the importance of its counterpart uPA in GAS disease.</abstract><cop>France</cop><pub>Elsevier Masson SAS</pub><pmid>31009808</pmid><doi>10.1016/j.micinf.2019.04.004</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1286-4579 |
| ispartof | Microbes and infection, 2019-10, Vol.21 (8-9), p.412-417 |
| issn | 1286-4579 1769-714X |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animal infection model Animals Bacterial Load Disease Models, Animal Mice Mice, Mutant Strains Mice, Transgenic Microbial Viability Mutation Plasminogen Streptococcal Infections - microbiology Streptococcal Infections - pathology Streptococcus pyogenes Streptococcus pyogenes - pathogenicity Streptokinase Tissue Plasminogen Activator - genetics Tissue Plasminogen Activator - metabolism Tissue-type plasminogen activator (tPA) Urokinase plasminogen activator (uPA) Virulence |
| title | Characterizing the role of tissue-type plasminogen activator in a mouse model of Group A streptococcal infection |
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