Characteristics of Patients With Chronic Hepatitis B Virus Infection With Genotype E Predominance in Burkina Faso
Hepatitis B virus (HBV) genotype E (HBV‐E) accounts for the majority of chronic hepatitis B (CHB) infections in West Africa. We aimed to determine factors associated with HBV‐E‐induced hepatocellular carcinoma (HCC) in West Africa. Data on patients from Burkina Faso who were hepatitis B surface anti...
Gespeichert in:
| Veröffentlicht in: | Hepatology communications 2020-12, Vol.4 (12), p.1781-1792 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1792 |
|---|---|
| container_issue | 12 |
| container_start_page | 1781 |
| container_title | Hepatology communications |
| container_volume | 4 |
| creator | Wongjarupong, Nicha Yonli, Albert Theophane Nagalo, Bolni Marius Djigma, Florencia Wendkuuni Somda, Sosthene Kounpielime Hassan, Mohamed A. Mohamed, Essa A. Sorgho, Abel Pegdwende Compaore, Tegwinde Rebeca Soubeiga, Serge Theophile Kiendrebeogo, Isabelle Sanou, Mahamoudou Diarra, Birama Yang, Hwai‐I Chen, Chien‐Jen Ouattara, Abdoul K. Zohoncon, Théodora M. Martinson, Jeremy J. Buetow, Kenneth Chamcheu, Jean Christopher Antwi, Samuel O. Borad, Mitesh J. Simpore, Jacques Roberts, Lewis R. |
| description | Hepatitis B virus (HBV) genotype E (HBV‐E) accounts for the majority of chronic hepatitis B (CHB) infections in West Africa. We aimed to determine factors associated with HBV‐E‐induced hepatocellular carcinoma (HCC) in West Africa. Data on patients from Burkina Faso who were hepatitis B surface antigen positive (HBsAg+) and had CHB were analyzed. HBV viral load and hepatitis B e antigen (HBeAg) status were measured in 3,885 individuals with CHB without HCC (CHB HCC−) and 59 individuals with CHB with HCC (CHB HCC+). HBV genotyping was performed for 364 subjects with CHB HCC− and 41 subjects with CHB HCC+. Overall, 2.5% of the CHB HCC− group was HBeAg+ compared with 0% of the CHB HCC+ group. Of the 364 patients who were CHB HCC− with available genotyping, the frequencies of HBV genotypes E and C/E were 70.3% and 12.9%, respectively. Age (odds ratio [OR] for older age, 1.08; 95% confidence interval [CI], 1.06‐1.10 per 1‐year increase in age), male sex (OR, 2.03; 95% CI, 1.11‐3.69), and HBV viremia (OR, 1.48; 95% CI, 1.31‐1.67 per 1 log10 IU/mL) were each associated with HCC diagnosis. Patients with genotype E had a lower HBeAg prevalence (6.3% vs. 14.9%), lower HBV viral load, and higher prevalence of cirrhosis (14.5% vs. 4.8%) than patients with genotype C/E. Conclusion: HBV‐E is the most common circulating strain (70.3%) in West African patients. HCC was associated with older age, male sex, and high HBV viral load. It is expected that these results will further inform guidance on clinical management of HBV infection in West Africa. |
| doi_str_mv | 10.1002/hep4.1595 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7706297</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2465704622</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4715-a95c4682ef2fd78f15b7791ec4671aed8150e87b1b1963f1eed45cf4addab4d03</originalsourceid><addsrcrecordid>eNp1kU9vEzEQxVcIRKvSA18AWeICh7S2117HFyQapU2lSuRA_9wsr3fMumzsre0F5dvjkFIVJE4ez_z09GZeVb0l-IRgTE97GNkJ4ZK_qA4pE2RGObt7-aw-qI5TuscYE0kJkfh1dVDXNeaEycPqYdHrqE2G6FJ2JqFg0VpnBz4ndOtyjxZ9DN4ZtIKx9LNL6AzduDgldOktmOyC34MX4EPejoCWaB2hCxvntTeAnEdnU_xefuhcp_CmemX1kOD48T2qrs-XXxer2dWXi8vF56uZKcb5TEtuWDOnYKntxNwS3gohCZSmIBq6OeEY5qIlLZFNbQlAx7ixTHedblmH66Pq0153nNoNdKZsFPWgxug2Om5V0E79PfGuV9_CDyUEbqgUReDDo0AMDxOkrDYuGRgG7SFMSZUDS8yIJKyg7_9B78MUfVmvUA0XmDWUFurjnjIxpBTBPpkhWO2yVLss1S7Lwr577v6J_JNcAU73wE83wPb_Smq1XLPfkr8A99yp9w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2465704622</pqid></control><display><type>article</type><title>Characteristics of Patients With Chronic Hepatitis B Virus Infection With Genotype E Predominance in Burkina Faso</title><source>DOAJ Directory of Open Access Journals</source><source>Access via Wiley Online Library</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Wiley Online Library (Open Access Collection)</source><source>PubMed Central</source><creator>Wongjarupong, Nicha ; Yonli, Albert Theophane ; Nagalo, Bolni Marius ; Djigma, Florencia Wendkuuni ; Somda, Sosthene Kounpielime ; Hassan, Mohamed A. ; Mohamed, Essa A. ; Sorgho, Abel Pegdwende ; Compaore, Tegwinde Rebeca ; Soubeiga, Serge Theophile ; Kiendrebeogo, Isabelle ; Sanou, Mahamoudou ; Diarra, Birama ; Yang, Hwai‐I ; Chen, Chien‐Jen ; Ouattara, Abdoul K. ; Zohoncon, Théodora M. ; Martinson, Jeremy J. ; Buetow, Kenneth ; Chamcheu, Jean Christopher ; Antwi, Samuel O. ; Borad, Mitesh J. ; Simpore, Jacques ; Roberts, Lewis R.</creator><creatorcontrib>Wongjarupong, Nicha ; Yonli, Albert Theophane ; Nagalo, Bolni Marius ; Djigma, Florencia Wendkuuni ; Somda, Sosthene Kounpielime ; Hassan, Mohamed A. ; Mohamed, Essa A. ; Sorgho, Abel Pegdwende ; Compaore, Tegwinde Rebeca ; Soubeiga, Serge Theophile ; Kiendrebeogo, Isabelle ; Sanou, Mahamoudou ; Diarra, Birama ; Yang, Hwai‐I ; Chen, Chien‐Jen ; Ouattara, Abdoul K. ; Zohoncon, Théodora M. ; Martinson, Jeremy J. ; Buetow, Kenneth ; Chamcheu, Jean Christopher ; Antwi, Samuel O. ; Borad, Mitesh J. ; Simpore, Jacques ; Roberts, Lewis R.</creatorcontrib><description>Hepatitis B virus (HBV) genotype E (HBV‐E) accounts for the majority of chronic hepatitis B (CHB) infections in West Africa. We aimed to determine factors associated with HBV‐E‐induced hepatocellular carcinoma (HCC) in West Africa. Data on patients from Burkina Faso who were hepatitis B surface antigen positive (HBsAg+) and had CHB were analyzed. HBV viral load and hepatitis B e antigen (HBeAg) status were measured in 3,885 individuals with CHB without HCC (CHB HCC−) and 59 individuals with CHB with HCC (CHB HCC+). HBV genotyping was performed for 364 subjects with CHB HCC− and 41 subjects with CHB HCC+. Overall, 2.5% of the CHB HCC− group was HBeAg+ compared with 0% of the CHB HCC+ group. Of the 364 patients who were CHB HCC− with available genotyping, the frequencies of HBV genotypes E and C/E were 70.3% and 12.9%, respectively. Age (odds ratio [OR] for older age, 1.08; 95% confidence interval [CI], 1.06‐1.10 per 1‐year increase in age), male sex (OR, 2.03; 95% CI, 1.11‐3.69), and HBV viremia (OR, 1.48; 95% CI, 1.31‐1.67 per 1 log10 IU/mL) were each associated with HCC diagnosis. Patients with genotype E had a lower HBeAg prevalence (6.3% vs. 14.9%), lower HBV viral load, and higher prevalence of cirrhosis (14.5% vs. 4.8%) than patients with genotype C/E. Conclusion: HBV‐E is the most common circulating strain (70.3%) in West African patients. HCC was associated with older age, male sex, and high HBV viral load. It is expected that these results will further inform guidance on clinical management of HBV infection in West Africa.</description><identifier>ISSN: 2471-254X</identifier><identifier>EISSN: 2471-254X</identifier><identifier>DOI: 10.1002/hep4.1595</identifier><identifier>PMID: 33305149</identifier><language>eng</language><publisher>United States: Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins</publisher><subject>Antibodies ; Antigens ; Biomedical research ; Deoxyribonucleic acid ; DNA ; Enzymes ; Genetic testing ; Genotype & phenotype ; Hepatitis B ; Infections ; Liver cancer ; Liver cirrhosis ; Liver diseases ; Mortality ; Original ; Patients ; Polymerase chain reaction ; Software</subject><ispartof>Hepatology communications, 2020-12, Vol.4 (12), p.1781-1792</ispartof><rights>2020 The Authors. Hepatology Communications published by Wiley Periodicals LLC on behalf of the American Association for the Study of Liver Diseases.</rights><rights>2020. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4715-a95c4682ef2fd78f15b7791ec4671aed8150e87b1b1963f1eed45cf4addab4d03</citedby><cites>FETCH-LOGICAL-c4715-a95c4682ef2fd78f15b7791ec4671aed8150e87b1b1963f1eed45cf4addab4d03</cites><orcidid>0000-0001-7885-8574 ; 0000-0001-8676-413X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7706297/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7706297/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1417,11562,27924,27925,45574,45575,46052,46476,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33305149$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wongjarupong, Nicha</creatorcontrib><creatorcontrib>Yonli, Albert Theophane</creatorcontrib><creatorcontrib>Nagalo, Bolni Marius</creatorcontrib><creatorcontrib>Djigma, Florencia Wendkuuni</creatorcontrib><creatorcontrib>Somda, Sosthene Kounpielime</creatorcontrib><creatorcontrib>Hassan, Mohamed A.</creatorcontrib><creatorcontrib>Mohamed, Essa A.</creatorcontrib><creatorcontrib>Sorgho, Abel Pegdwende</creatorcontrib><creatorcontrib>Compaore, Tegwinde Rebeca</creatorcontrib><creatorcontrib>Soubeiga, Serge Theophile</creatorcontrib><creatorcontrib>Kiendrebeogo, Isabelle</creatorcontrib><creatorcontrib>Sanou, Mahamoudou</creatorcontrib><creatorcontrib>Diarra, Birama</creatorcontrib><creatorcontrib>Yang, Hwai‐I</creatorcontrib><creatorcontrib>Chen, Chien‐Jen</creatorcontrib><creatorcontrib>Ouattara, Abdoul K.</creatorcontrib><creatorcontrib>Zohoncon, Théodora M.</creatorcontrib><creatorcontrib>Martinson, Jeremy J.</creatorcontrib><creatorcontrib>Buetow, Kenneth</creatorcontrib><creatorcontrib>Chamcheu, Jean Christopher</creatorcontrib><creatorcontrib>Antwi, Samuel O.</creatorcontrib><creatorcontrib>Borad, Mitesh J.</creatorcontrib><creatorcontrib>Simpore, Jacques</creatorcontrib><creatorcontrib>Roberts, Lewis R.</creatorcontrib><title>Characteristics of Patients With Chronic Hepatitis B Virus Infection With Genotype E Predominance in Burkina Faso</title><title>Hepatology communications</title><addtitle>Hepatol Commun</addtitle><description>Hepatitis B virus (HBV) genotype E (HBV‐E) accounts for the majority of chronic hepatitis B (CHB) infections in West Africa. We aimed to determine factors associated with HBV‐E‐induced hepatocellular carcinoma (HCC) in West Africa. Data on patients from Burkina Faso who were hepatitis B surface antigen positive (HBsAg+) and had CHB were analyzed. HBV viral load and hepatitis B e antigen (HBeAg) status were measured in 3,885 individuals with CHB without HCC (CHB HCC−) and 59 individuals with CHB with HCC (CHB HCC+). HBV genotyping was performed for 364 subjects with CHB HCC− and 41 subjects with CHB HCC+. Overall, 2.5% of the CHB HCC− group was HBeAg+ compared with 0% of the CHB HCC+ group. Of the 364 patients who were CHB HCC− with available genotyping, the frequencies of HBV genotypes E and C/E were 70.3% and 12.9%, respectively. Age (odds ratio [OR] for older age, 1.08; 95% confidence interval [CI], 1.06‐1.10 per 1‐year increase in age), male sex (OR, 2.03; 95% CI, 1.11‐3.69), and HBV viremia (OR, 1.48; 95% CI, 1.31‐1.67 per 1 log10 IU/mL) were each associated with HCC diagnosis. Patients with genotype E had a lower HBeAg prevalence (6.3% vs. 14.9%), lower HBV viral load, and higher prevalence of cirrhosis (14.5% vs. 4.8%) than patients with genotype C/E. Conclusion: HBV‐E is the most common circulating strain (70.3%) in West African patients. HCC was associated with older age, male sex, and high HBV viral load. It is expected that these results will further inform guidance on clinical management of HBV infection in West Africa.</description><subject>Antibodies</subject><subject>Antigens</subject><subject>Biomedical research</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Enzymes</subject><subject>Genetic testing</subject><subject>Genotype & phenotype</subject><subject>Hepatitis B</subject><subject>Infections</subject><subject>Liver cancer</subject><subject>Liver cirrhosis</subject><subject>Liver diseases</subject><subject>Mortality</subject><subject>Original</subject><subject>Patients</subject><subject>Polymerase chain reaction</subject><subject>Software</subject><issn>2471-254X</issn><issn>2471-254X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp1kU9vEzEQxVcIRKvSA18AWeICh7S2117HFyQapU2lSuRA_9wsr3fMumzsre0F5dvjkFIVJE4ez_z09GZeVb0l-IRgTE97GNkJ4ZK_qA4pE2RGObt7-aw-qI5TuscYE0kJkfh1dVDXNeaEycPqYdHrqE2G6FJ2JqFg0VpnBz4ndOtyjxZ9DN4ZtIKx9LNL6AzduDgldOktmOyC34MX4EPejoCWaB2hCxvntTeAnEdnU_xefuhcp_CmemX1kOD48T2qrs-XXxer2dWXi8vF56uZKcb5TEtuWDOnYKntxNwS3gohCZSmIBq6OeEY5qIlLZFNbQlAx7ixTHedblmH66Pq0153nNoNdKZsFPWgxug2Om5V0E79PfGuV9_CDyUEbqgUReDDo0AMDxOkrDYuGRgG7SFMSZUDS8yIJKyg7_9B78MUfVmvUA0XmDWUFurjnjIxpBTBPpkhWO2yVLss1S7Lwr577v6J_JNcAU73wE83wPb_Smq1XLPfkr8A99yp9w</recordid><startdate>202012</startdate><enddate>202012</enddate><creator>Wongjarupong, Nicha</creator><creator>Yonli, Albert Theophane</creator><creator>Nagalo, Bolni Marius</creator><creator>Djigma, Florencia Wendkuuni</creator><creator>Somda, Sosthene Kounpielime</creator><creator>Hassan, Mohamed A.</creator><creator>Mohamed, Essa A.</creator><creator>Sorgho, Abel Pegdwende</creator><creator>Compaore, Tegwinde Rebeca</creator><creator>Soubeiga, Serge Theophile</creator><creator>Kiendrebeogo, Isabelle</creator><creator>Sanou, Mahamoudou</creator><creator>Diarra, Birama</creator><creator>Yang, Hwai‐I</creator><creator>Chen, Chien‐Jen</creator><creator>Ouattara, Abdoul K.</creator><creator>Zohoncon, Théodora M.</creator><creator>Martinson, Jeremy J.</creator><creator>Buetow, Kenneth</creator><creator>Chamcheu, Jean Christopher</creator><creator>Antwi, Samuel O.</creator><creator>Borad, Mitesh J.</creator><creator>Simpore, Jacques</creator><creator>Roberts, Lewis R.</creator><general>Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7885-8574</orcidid><orcidid>https://orcid.org/0000-0001-8676-413X</orcidid></search><sort><creationdate>202012</creationdate><title>Characteristics of Patients With Chronic Hepatitis B Virus Infection With Genotype E Predominance in Burkina Faso</title><author>Wongjarupong, Nicha ; Yonli, Albert Theophane ; Nagalo, Bolni Marius ; Djigma, Florencia Wendkuuni ; Somda, Sosthene Kounpielime ; Hassan, Mohamed A. ; Mohamed, Essa A. ; Sorgho, Abel Pegdwende ; Compaore, Tegwinde Rebeca ; Soubeiga, Serge Theophile ; Kiendrebeogo, Isabelle ; Sanou, Mahamoudou ; Diarra, Birama ; Yang, Hwai‐I ; Chen, Chien‐Jen ; Ouattara, Abdoul K. ; Zohoncon, Théodora M. ; Martinson, Jeremy J. ; Buetow, Kenneth ; Chamcheu, Jean Christopher ; Antwi, Samuel O. ; Borad, Mitesh J. ; Simpore, Jacques ; Roberts, Lewis R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4715-a95c4682ef2fd78f15b7791ec4671aed8150e87b1b1963f1eed45cf4addab4d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antibodies</topic><topic>Antigens</topic><topic>Biomedical research</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Enzymes</topic><topic>Genetic testing</topic><topic>Genotype & phenotype</topic><topic>Hepatitis B</topic><topic>Infections</topic><topic>Liver cancer</topic><topic>Liver cirrhosis</topic><topic>Liver diseases</topic><topic>Mortality</topic><topic>Original</topic><topic>Patients</topic><topic>Polymerase chain reaction</topic><topic>Software</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wongjarupong, Nicha</creatorcontrib><creatorcontrib>Yonli, Albert Theophane</creatorcontrib><creatorcontrib>Nagalo, Bolni Marius</creatorcontrib><creatorcontrib>Djigma, Florencia Wendkuuni</creatorcontrib><creatorcontrib>Somda, Sosthene Kounpielime</creatorcontrib><creatorcontrib>Hassan, Mohamed A.</creatorcontrib><creatorcontrib>Mohamed, Essa A.</creatorcontrib><creatorcontrib>Sorgho, Abel Pegdwende</creatorcontrib><creatorcontrib>Compaore, Tegwinde Rebeca</creatorcontrib><creatorcontrib>Soubeiga, Serge Theophile</creatorcontrib><creatorcontrib>Kiendrebeogo, Isabelle</creatorcontrib><creatorcontrib>Sanou, Mahamoudou</creatorcontrib><creatorcontrib>Diarra, Birama</creatorcontrib><creatorcontrib>Yang, Hwai‐I</creatorcontrib><creatorcontrib>Chen, Chien‐Jen</creatorcontrib><creatorcontrib>Ouattara, Abdoul K.</creatorcontrib><creatorcontrib>Zohoncon, Théodora M.</creatorcontrib><creatorcontrib>Martinson, Jeremy J.</creatorcontrib><creatorcontrib>Buetow, Kenneth</creatorcontrib><creatorcontrib>Chamcheu, Jean Christopher</creatorcontrib><creatorcontrib>Antwi, Samuel O.</creatorcontrib><creatorcontrib>Borad, Mitesh J.</creatorcontrib><creatorcontrib>Simpore, Jacques</creatorcontrib><creatorcontrib>Roberts, Lewis R.</creatorcontrib><collection>Wiley Online Library (Open Access Collection)</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Hepatology communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wongjarupong, Nicha</au><au>Yonli, Albert Theophane</au><au>Nagalo, Bolni Marius</au><au>Djigma, Florencia Wendkuuni</au><au>Somda, Sosthene Kounpielime</au><au>Hassan, Mohamed A.</au><au>Mohamed, Essa A.</au><au>Sorgho, Abel Pegdwende</au><au>Compaore, Tegwinde Rebeca</au><au>Soubeiga, Serge Theophile</au><au>Kiendrebeogo, Isabelle</au><au>Sanou, Mahamoudou</au><au>Diarra, Birama</au><au>Yang, Hwai‐I</au><au>Chen, Chien‐Jen</au><au>Ouattara, Abdoul K.</au><au>Zohoncon, Théodora M.</au><au>Martinson, Jeremy J.</au><au>Buetow, Kenneth</au><au>Chamcheu, Jean Christopher</au><au>Antwi, Samuel O.</au><au>Borad, Mitesh J.</au><au>Simpore, Jacques</au><au>Roberts, Lewis R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characteristics of Patients With Chronic Hepatitis B Virus Infection With Genotype E Predominance in Burkina Faso</atitle><jtitle>Hepatology communications</jtitle><addtitle>Hepatol Commun</addtitle><date>2020-12</date><risdate>2020</risdate><volume>4</volume><issue>12</issue><spage>1781</spage><epage>1792</epage><pages>1781-1792</pages><issn>2471-254X</issn><eissn>2471-254X</eissn><abstract>Hepatitis B virus (HBV) genotype E (HBV‐E) accounts for the majority of chronic hepatitis B (CHB) infections in West Africa. We aimed to determine factors associated with HBV‐E‐induced hepatocellular carcinoma (HCC) in West Africa. Data on patients from Burkina Faso who were hepatitis B surface antigen positive (HBsAg+) and had CHB were analyzed. HBV viral load and hepatitis B e antigen (HBeAg) status were measured in 3,885 individuals with CHB without HCC (CHB HCC−) and 59 individuals with CHB with HCC (CHB HCC+). HBV genotyping was performed for 364 subjects with CHB HCC− and 41 subjects with CHB HCC+. Overall, 2.5% of the CHB HCC− group was HBeAg+ compared with 0% of the CHB HCC+ group. Of the 364 patients who were CHB HCC− with available genotyping, the frequencies of HBV genotypes E and C/E were 70.3% and 12.9%, respectively. Age (odds ratio [OR] for older age, 1.08; 95% confidence interval [CI], 1.06‐1.10 per 1‐year increase in age), male sex (OR, 2.03; 95% CI, 1.11‐3.69), and HBV viremia (OR, 1.48; 95% CI, 1.31‐1.67 per 1 log10 IU/mL) were each associated with HCC diagnosis. Patients with genotype E had a lower HBeAg prevalence (6.3% vs. 14.9%), lower HBV viral load, and higher prevalence of cirrhosis (14.5% vs. 4.8%) than patients with genotype C/E. Conclusion: HBV‐E is the most common circulating strain (70.3%) in West African patients. HCC was associated with older age, male sex, and high HBV viral load. It is expected that these results will further inform guidance on clinical management of HBV infection in West Africa.</abstract><cop>United States</cop><pub>Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins</pub><pmid>33305149</pmid><doi>10.1002/hep4.1595</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-7885-8574</orcidid><orcidid>https://orcid.org/0000-0001-8676-413X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2471-254X |
| ispartof | Hepatology communications, 2020-12, Vol.4 (12), p.1781-1792 |
| issn | 2471-254X 2471-254X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7706297 |
| source | DOAJ Directory of Open Access Journals; Access via Wiley Online Library; EZB-FREE-00999 freely available EZB journals; Wiley Online Library (Open Access Collection); PubMed Central |
| subjects | Antibodies Antigens Biomedical research Deoxyribonucleic acid DNA Enzymes Genetic testing Genotype & phenotype Hepatitis B Infections Liver cancer Liver cirrhosis Liver diseases Mortality Original Patients Polymerase chain reaction Software |
| title | Characteristics of Patients With Chronic Hepatitis B Virus Infection With Genotype E Predominance in Burkina Faso |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T22%3A20%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Characteristics%20of%20Patients%20With%20Chronic%20Hepatitis%20B%20Virus%20Infection%20With%20Genotype%20E%20Predominance%20in%20Burkina%20Faso&rft.jtitle=Hepatology%20communications&rft.au=Wongjarupong,%20Nicha&rft.date=2020-12&rft.volume=4&rft.issue=12&rft.spage=1781&rft.epage=1792&rft.pages=1781-1792&rft.issn=2471-254X&rft.eissn=2471-254X&rft_id=info:doi/10.1002/hep4.1595&rft_dat=%3Cproquest_pubme%3E2465704622%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2465704622&rft_id=info:pmid/33305149&rfr_iscdi=true |