Depletion of circulating IgM memory B cells predicts unfavourable outcome in COVID-19
Impaired immune responses have been hypothesised to be a possible trigger of unfavourable outcomes in coronavirus disease 2019 (COVID-19). We aimed to characterise IgM memory B cells in patients with COVID-19 admitted to an internal medicine ward in Northern Italy. Overall, 66 COVID-19 patients (mea...
Gespeichert in:
| Veröffentlicht in: | Scientific reports 2020-11, Vol.10 (1), p.20836-20836, Article 20836 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 20836 |
|---|---|
| container_issue | 1 |
| container_start_page | 20836 |
| container_title | Scientific reports |
| container_volume | 10 |
| creator | Lenti, Marco Vincenzo Aronico, Nicola Pellegrino, Ivan Boveri, Emanuela Giuffrida, Paolo Borrelli de Andreis, Federica Morbini, Patrizia Vanelli, Laura Pasini, Alessandra Ubezio, Cristina Melazzini, Federica Rascaroli, Alessandro Antoci, Valentina Merli, Stefania Di Terlizzi, Francesco Sabatini, Umberto Cambiè, Ginevra Tenore, Annamaria Picone, Cristina Vanoli, Alessandro Arcaini, Luca Baldanti, Fausto Paulli, Marco Corazza, Gino Roberto Di Sabatino, Antonio |
| description | Impaired immune responses have been hypothesised to be a possible trigger of unfavourable outcomes in coronavirus disease 2019 (COVID-19). We aimed to characterise IgM memory B cells in patients with COVID-19 admitted to an internal medicine ward in Northern Italy. Overall, 66 COVID-19 patients (mean age 74 ± 16.6 years; 29 females) were enrolled. Three patients (4.5%; 1 female) had been splenectomised and were excluded from further analyses. Fifty-five patients (87.3%) had IgM memory B cell depletion, and 18 (28.6%) died during hospitalisation (cumulative incidence rate 9.26/100 person-week; 5.8–14.7 95% CI). All patients who died had IgM memory B cell depletion. A superimposed infection was found in 6 patients (9.5%), all of them having IgM memory B cell depletion (cumulative incidence rate 3.08/100 person-week; 1.3–6.8 95% CI). At bivariable analyses, older age, sex, number of comorbidities, and peripheral blood lymphocyte count |
| doi_str_mv | 10.1038/s41598-020-77945-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7705651</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2466034399</sourcerecordid><originalsourceid>FETCH-LOGICAL-c571t-547822c1a6cfb16dc25bbb452f2a823b1c60a85623229cc87d87e20ebb0396fd3</originalsourceid><addsrcrecordid>eNp9kU9vFSEUxYnR2Kb2C7gwJG7cjIXLMMDGRF_VvqRNN61bAgzzpJmBJ8w06beX56v940I23OT-7rkcDkJvKflICZMnpaVcyYYAaYRQLW_kC3QIpBbAAF4-qQ_QcSk3pB4OqqXqNTpgDLgQgh-i61O_Hf0cUsRpwC5kt4xmDnGD15sLPPkp5Tv8BTs_jgVvs--Dmwte4mBu05KNHT1Oy-zS5HGIeHX5Y33aUPUGvRrMWPzx_X2Err99vVqdNeeX39erz-eN44LODW-FBHDUdG6wtOsdcGtty2EAI4FZ6jpiJO92LpRzUvRSeCDeWsJUN_TsCH3a624XO_ne-ThnM-ptDpPJdzqZoJ93YvipN-lWC0F4x2kV-HAvkNOvxZdZT6HszJro01I0tF1HWMuUquj7f9Cb-gOx2quUYCAo4zsK9pTLqZTsh4fHUKJ3wel9cLoGp_8Ep2UdevfUxsPI35gqwPZAqa248flx939kfwOEcqL-</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2473271359</pqid></control><display><type>article</type><title>Depletion of circulating IgM memory B cells predicts unfavourable outcome in COVID-19</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Springer Nature OA Free Journals</source><source>Nature Free</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Lenti, Marco Vincenzo ; Aronico, Nicola ; Pellegrino, Ivan ; Boveri, Emanuela ; Giuffrida, Paolo ; Borrelli de Andreis, Federica ; Morbini, Patrizia ; Vanelli, Laura ; Pasini, Alessandra ; Ubezio, Cristina ; Melazzini, Federica ; Rascaroli, Alessandro ; Antoci, Valentina ; Merli, Stefania ; Di Terlizzi, Francesco ; Sabatini, Umberto ; Cambiè, Ginevra ; Tenore, Annamaria ; Picone, Cristina ; Vanoli, Alessandro ; Arcaini, Luca ; Baldanti, Fausto ; Paulli, Marco ; Corazza, Gino Roberto ; Di Sabatino, Antonio</creator><creatorcontrib>Lenti, Marco Vincenzo ; Aronico, Nicola ; Pellegrino, Ivan ; Boveri, Emanuela ; Giuffrida, Paolo ; Borrelli de Andreis, Federica ; Morbini, Patrizia ; Vanelli, Laura ; Pasini, Alessandra ; Ubezio, Cristina ; Melazzini, Federica ; Rascaroli, Alessandro ; Antoci, Valentina ; Merli, Stefania ; Di Terlizzi, Francesco ; Sabatini, Umberto ; Cambiè, Ginevra ; Tenore, Annamaria ; Picone, Cristina ; Vanoli, Alessandro ; Arcaini, Luca ; Baldanti, Fausto ; Paulli, Marco ; Corazza, Gino Roberto ; Di Sabatino, Antonio</creatorcontrib><description>Impaired immune responses have been hypothesised to be a possible trigger of unfavourable outcomes in coronavirus disease 2019 (COVID-19). We aimed to characterise IgM memory B cells in patients with COVID-19 admitted to an internal medicine ward in Northern Italy. Overall, 66 COVID-19 patients (mean age 74 ± 16.6 years; 29 females) were enrolled. Three patients (4.5%; 1 female) had been splenectomised and were excluded from further analyses. Fifty-five patients (87.3%) had IgM memory B cell depletion, and 18 (28.6%) died during hospitalisation (cumulative incidence rate 9.26/100 person-week; 5.8–14.7 95% CI). All patients who died had IgM memory B cell depletion. A superimposed infection was found in 6 patients (9.5%), all of them having IgM memory B cell depletion (cumulative incidence rate 3.08/100 person-week; 1.3–6.8 95% CI). At bivariable analyses, older age, sex, number of comorbidities, and peripheral blood lymphocyte count < 1500/µl were not correlated with IgM memory B cell depletion. A discrete-to-marked reduction of the B-cell compartment was also noticed in autoptic spleen specimens of two COVID-19 patients. We conclude that IgM memory B cells are commonly depleted in COVID-19 patients and this correlates with increased mortality and superimposed infections.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-77945-8</identifier><identifier>PMID: 33257775</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/250/1619 ; 631/250/2152 ; 631/250/255 ; 692/420/2780 ; Adult ; Aged ; Aged, 80 and over ; B-Lymphocyte Subsets - cytology ; B-Lymphocyte Subsets - immunology ; B-Lymphocytes - cytology ; B-Lymphocytes - immunology ; Cell number ; Coronaviruses ; COVID-19 ; COVID-19 - mortality ; COVID-19 - pathology ; Female ; Hospital Mortality ; Humanities and Social Sciences ; Humans ; Immunoglobulin M ; Immunoglobulin M - blood ; Immunologic Memory - immunology ; Immunological memory ; Longitudinal Studies ; Lymphocyte Count ; Lymphocyte Depletion ; Lymphocytes ; Lymphocytes B ; Male ; Memory cells ; Middle Aged ; multidisciplinary ; Peripheral blood ; Prospective Studies ; SARS-CoV-2 - immunology ; Science ; Science (multidisciplinary) ; Spleen ; Spleen - cytology ; Spleen - immunology</subject><ispartof>Scientific reports, 2020-11, Vol.10 (1), p.20836-20836, Article 20836</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c571t-547822c1a6cfb16dc25bbb452f2a823b1c60a85623229cc87d87e20ebb0396fd3</citedby><cites>FETCH-LOGICAL-c571t-547822c1a6cfb16dc25bbb452f2a823b1c60a85623229cc87d87e20ebb0396fd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705651/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705651/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33257775$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lenti, Marco Vincenzo</creatorcontrib><creatorcontrib>Aronico, Nicola</creatorcontrib><creatorcontrib>Pellegrino, Ivan</creatorcontrib><creatorcontrib>Boveri, Emanuela</creatorcontrib><creatorcontrib>Giuffrida, Paolo</creatorcontrib><creatorcontrib>Borrelli de Andreis, Federica</creatorcontrib><creatorcontrib>Morbini, Patrizia</creatorcontrib><creatorcontrib>Vanelli, Laura</creatorcontrib><creatorcontrib>Pasini, Alessandra</creatorcontrib><creatorcontrib>Ubezio, Cristina</creatorcontrib><creatorcontrib>Melazzini, Federica</creatorcontrib><creatorcontrib>Rascaroli, Alessandro</creatorcontrib><creatorcontrib>Antoci, Valentina</creatorcontrib><creatorcontrib>Merli, Stefania</creatorcontrib><creatorcontrib>Di Terlizzi, Francesco</creatorcontrib><creatorcontrib>Sabatini, Umberto</creatorcontrib><creatorcontrib>Cambiè, Ginevra</creatorcontrib><creatorcontrib>Tenore, Annamaria</creatorcontrib><creatorcontrib>Picone, Cristina</creatorcontrib><creatorcontrib>Vanoli, Alessandro</creatorcontrib><creatorcontrib>Arcaini, Luca</creatorcontrib><creatorcontrib>Baldanti, Fausto</creatorcontrib><creatorcontrib>Paulli, Marco</creatorcontrib><creatorcontrib>Corazza, Gino Roberto</creatorcontrib><creatorcontrib>Di Sabatino, Antonio</creatorcontrib><title>Depletion of circulating IgM memory B cells predicts unfavourable outcome in COVID-19</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Impaired immune responses have been hypothesised to be a possible trigger of unfavourable outcomes in coronavirus disease 2019 (COVID-19). We aimed to characterise IgM memory B cells in patients with COVID-19 admitted to an internal medicine ward in Northern Italy. Overall, 66 COVID-19 patients (mean age 74 ± 16.6 years; 29 females) were enrolled. Three patients (4.5%; 1 female) had been splenectomised and were excluded from further analyses. Fifty-five patients (87.3%) had IgM memory B cell depletion, and 18 (28.6%) died during hospitalisation (cumulative incidence rate 9.26/100 person-week; 5.8–14.7 95% CI). All patients who died had IgM memory B cell depletion. A superimposed infection was found in 6 patients (9.5%), all of them having IgM memory B cell depletion (cumulative incidence rate 3.08/100 person-week; 1.3–6.8 95% CI). At bivariable analyses, older age, sex, number of comorbidities, and peripheral blood lymphocyte count < 1500/µl were not correlated with IgM memory B cell depletion. A discrete-to-marked reduction of the B-cell compartment was also noticed in autoptic spleen specimens of two COVID-19 patients. We conclude that IgM memory B cells are commonly depleted in COVID-19 patients and this correlates with increased mortality and superimposed infections.</description><subject>631/250/1619</subject><subject>631/250/2152</subject><subject>631/250/255</subject><subject>692/420/2780</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>B-Lymphocyte Subsets - cytology</subject><subject>B-Lymphocyte Subsets - immunology</subject><subject>B-Lymphocytes - cytology</subject><subject>B-Lymphocytes - immunology</subject><subject>Cell number</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 - mortality</subject><subject>COVID-19 - pathology</subject><subject>Female</subject><subject>Hospital Mortality</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Immunoglobulin M</subject><subject>Immunoglobulin M - blood</subject><subject>Immunologic Memory - immunology</subject><subject>Immunological memory</subject><subject>Longitudinal Studies</subject><subject>Lymphocyte Count</subject><subject>Lymphocyte Depletion</subject><subject>Lymphocytes</subject><subject>Lymphocytes B</subject><subject>Male</subject><subject>Memory cells</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Peripheral blood</subject><subject>Prospective Studies</subject><subject>SARS-CoV-2 - immunology</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Spleen</subject><subject>Spleen - cytology</subject><subject>Spleen - immunology</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU9vFSEUxYnR2Kb2C7gwJG7cjIXLMMDGRF_VvqRNN61bAgzzpJmBJ8w06beX56v940I23OT-7rkcDkJvKflICZMnpaVcyYYAaYRQLW_kC3QIpBbAAF4-qQ_QcSk3pB4OqqXqNTpgDLgQgh-i61O_Hf0cUsRpwC5kt4xmDnGD15sLPPkp5Tv8BTs_jgVvs--Dmwte4mBu05KNHT1Oy-zS5HGIeHX5Y33aUPUGvRrMWPzx_X2Err99vVqdNeeX39erz-eN44LODW-FBHDUdG6wtOsdcGtty2EAI4FZ6jpiJO92LpRzUvRSeCDeWsJUN_TsCH3a624XO_ne-ThnM-ptDpPJdzqZoJ93YvipN-lWC0F4x2kV-HAvkNOvxZdZT6HszJro01I0tF1HWMuUquj7f9Cb-gOx2quUYCAo4zsK9pTLqZTsh4fHUKJ3wel9cLoGp_8Ep2UdevfUxsPI35gqwPZAqa248flx939kfwOEcqL-</recordid><startdate>20201130</startdate><enddate>20201130</enddate><creator>Lenti, Marco Vincenzo</creator><creator>Aronico, Nicola</creator><creator>Pellegrino, Ivan</creator><creator>Boveri, Emanuela</creator><creator>Giuffrida, Paolo</creator><creator>Borrelli de Andreis, Federica</creator><creator>Morbini, Patrizia</creator><creator>Vanelli, Laura</creator><creator>Pasini, Alessandra</creator><creator>Ubezio, Cristina</creator><creator>Melazzini, Federica</creator><creator>Rascaroli, Alessandro</creator><creator>Antoci, Valentina</creator><creator>Merli, Stefania</creator><creator>Di Terlizzi, Francesco</creator><creator>Sabatini, Umberto</creator><creator>Cambiè, Ginevra</creator><creator>Tenore, Annamaria</creator><creator>Picone, Cristina</creator><creator>Vanoli, Alessandro</creator><creator>Arcaini, Luca</creator><creator>Baldanti, Fausto</creator><creator>Paulli, Marco</creator><creator>Corazza, Gino Roberto</creator><creator>Di Sabatino, Antonio</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20201130</creationdate><title>Depletion of circulating IgM memory B cells predicts unfavourable outcome in COVID-19</title><author>Lenti, Marco Vincenzo ; Aronico, Nicola ; Pellegrino, Ivan ; Boveri, Emanuela ; Giuffrida, Paolo ; Borrelli de Andreis, Federica ; Morbini, Patrizia ; Vanelli, Laura ; Pasini, Alessandra ; Ubezio, Cristina ; Melazzini, Federica ; Rascaroli, Alessandro ; Antoci, Valentina ; Merli, Stefania ; Di Terlizzi, Francesco ; Sabatini, Umberto ; Cambiè, Ginevra ; Tenore, Annamaria ; Picone, Cristina ; Vanoli, Alessandro ; Arcaini, Luca ; Baldanti, Fausto ; Paulli, Marco ; Corazza, Gino Roberto ; Di Sabatino, Antonio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c571t-547822c1a6cfb16dc25bbb452f2a823b1c60a85623229cc87d87e20ebb0396fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>631/250/1619</topic><topic>631/250/2152</topic><topic>631/250/255</topic><topic>692/420/2780</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>B-Lymphocyte Subsets - cytology</topic><topic>B-Lymphocyte Subsets - immunology</topic><topic>B-Lymphocytes - cytology</topic><topic>B-Lymphocytes - immunology</topic><topic>Cell number</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>COVID-19 - mortality</topic><topic>COVID-19 - pathology</topic><topic>Female</topic><topic>Hospital Mortality</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Immunoglobulin M</topic><topic>Immunoglobulin M - blood</topic><topic>Immunologic Memory - immunology</topic><topic>Immunological memory</topic><topic>Longitudinal Studies</topic><topic>Lymphocyte Count</topic><topic>Lymphocyte Depletion</topic><topic>Lymphocytes</topic><topic>Lymphocytes B</topic><topic>Male</topic><topic>Memory cells</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>Peripheral blood</topic><topic>Prospective Studies</topic><topic>SARS-CoV-2 - immunology</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Spleen</topic><topic>Spleen - cytology</topic><topic>Spleen - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lenti, Marco Vincenzo</creatorcontrib><creatorcontrib>Aronico, Nicola</creatorcontrib><creatorcontrib>Pellegrino, Ivan</creatorcontrib><creatorcontrib>Boveri, Emanuela</creatorcontrib><creatorcontrib>Giuffrida, Paolo</creatorcontrib><creatorcontrib>Borrelli de Andreis, Federica</creatorcontrib><creatorcontrib>Morbini, Patrizia</creatorcontrib><creatorcontrib>Vanelli, Laura</creatorcontrib><creatorcontrib>Pasini, Alessandra</creatorcontrib><creatorcontrib>Ubezio, Cristina</creatorcontrib><creatorcontrib>Melazzini, Federica</creatorcontrib><creatorcontrib>Rascaroli, Alessandro</creatorcontrib><creatorcontrib>Antoci, Valentina</creatorcontrib><creatorcontrib>Merli, Stefania</creatorcontrib><creatorcontrib>Di Terlizzi, Francesco</creatorcontrib><creatorcontrib>Sabatini, Umberto</creatorcontrib><creatorcontrib>Cambiè, Ginevra</creatorcontrib><creatorcontrib>Tenore, Annamaria</creatorcontrib><creatorcontrib>Picone, Cristina</creatorcontrib><creatorcontrib>Vanoli, Alessandro</creatorcontrib><creatorcontrib>Arcaini, Luca</creatorcontrib><creatorcontrib>Baldanti, Fausto</creatorcontrib><creatorcontrib>Paulli, Marco</creatorcontrib><creatorcontrib>Corazza, Gino Roberto</creatorcontrib><creatorcontrib>Di Sabatino, Antonio</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lenti, Marco Vincenzo</au><au>Aronico, Nicola</au><au>Pellegrino, Ivan</au><au>Boveri, Emanuela</au><au>Giuffrida, Paolo</au><au>Borrelli de Andreis, Federica</au><au>Morbini, Patrizia</au><au>Vanelli, Laura</au><au>Pasini, Alessandra</au><au>Ubezio, Cristina</au><au>Melazzini, Federica</au><au>Rascaroli, Alessandro</au><au>Antoci, Valentina</au><au>Merli, Stefania</au><au>Di Terlizzi, Francesco</au><au>Sabatini, Umberto</au><au>Cambiè, Ginevra</au><au>Tenore, Annamaria</au><au>Picone, Cristina</au><au>Vanoli, Alessandro</au><au>Arcaini, Luca</au><au>Baldanti, Fausto</au><au>Paulli, Marco</au><au>Corazza, Gino Roberto</au><au>Di Sabatino, Antonio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Depletion of circulating IgM memory B cells predicts unfavourable outcome in COVID-19</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-11-30</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>20836</spage><epage>20836</epage><pages>20836-20836</pages><artnum>20836</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Impaired immune responses have been hypothesised to be a possible trigger of unfavourable outcomes in coronavirus disease 2019 (COVID-19). We aimed to characterise IgM memory B cells in patients with COVID-19 admitted to an internal medicine ward in Northern Italy. Overall, 66 COVID-19 patients (mean age 74 ± 16.6 years; 29 females) were enrolled. Three patients (4.5%; 1 female) had been splenectomised and were excluded from further analyses. Fifty-five patients (87.3%) had IgM memory B cell depletion, and 18 (28.6%) died during hospitalisation (cumulative incidence rate 9.26/100 person-week; 5.8–14.7 95% CI). All patients who died had IgM memory B cell depletion. A superimposed infection was found in 6 patients (9.5%), all of them having IgM memory B cell depletion (cumulative incidence rate 3.08/100 person-week; 1.3–6.8 95% CI). At bivariable analyses, older age, sex, number of comorbidities, and peripheral blood lymphocyte count < 1500/µl were not correlated with IgM memory B cell depletion. A discrete-to-marked reduction of the B-cell compartment was also noticed in autoptic spleen specimens of two COVID-19 patients. We conclude that IgM memory B cells are commonly depleted in COVID-19 patients and this correlates with increased mortality and superimposed infections.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33257775</pmid><doi>10.1038/s41598-020-77945-8</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2045-2322 |
| ispartof | Scientific reports, 2020-11, Vol.10 (1), p.20836-20836, Article 20836 |
| issn | 2045-2322 2045-2322 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7705651 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Springer Nature OA Free Journals; Nature Free; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | 631/250/1619 631/250/2152 631/250/255 692/420/2780 Adult Aged Aged, 80 and over B-Lymphocyte Subsets - cytology B-Lymphocyte Subsets - immunology B-Lymphocytes - cytology B-Lymphocytes - immunology Cell number Coronaviruses COVID-19 COVID-19 - mortality COVID-19 - pathology Female Hospital Mortality Humanities and Social Sciences Humans Immunoglobulin M Immunoglobulin M - blood Immunologic Memory - immunology Immunological memory Longitudinal Studies Lymphocyte Count Lymphocyte Depletion Lymphocytes Lymphocytes B Male Memory cells Middle Aged multidisciplinary Peripheral blood Prospective Studies SARS-CoV-2 - immunology Science Science (multidisciplinary) Spleen Spleen - cytology Spleen - immunology |
| title | Depletion of circulating IgM memory B cells predicts unfavourable outcome in COVID-19 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T03%3A31%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Depletion%20of%20circulating%20IgM%20memory%20B%20cells%20predicts%20unfavourable%20outcome%20in%20COVID-19&rft.jtitle=Scientific%20reports&rft.au=Lenti,%20Marco%20Vincenzo&rft.date=2020-11-30&rft.volume=10&rft.issue=1&rft.spage=20836&rft.epage=20836&rft.pages=20836-20836&rft.artnum=20836&rft.issn=2045-2322&rft.eissn=2045-2322&rft_id=info:doi/10.1038/s41598-020-77945-8&rft_dat=%3Cproquest_pubme%3E2466034399%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2473271359&rft_id=info:pmid/33257775&rfr_iscdi=true |