Dalbavancin binds ACE2 to block its interaction with SARS-CoV-2 spike protein and is effective in inhibiting SARS-CoV-2 infection in animal models

Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic worldwide. Currently, however, no effective drug or vaccine is available to treat or prevent the resulting coronavirus disease 2019 (COVID-19). Here, we report our discovery of a promising anti-COVID-19...

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Veröffentlicht in:	Cell research 2021-01, Vol.31 (1), p.17-24
Hauptverfasser:	Wang, Gan, Yang, Meng-Li, Duan, Zi-Lei, Liu, Feng-Liang, Jin, Lin, Long, Cheng-Bo, Zhang, Min, Tang, Xiao-Peng, Xu, Ling, Li, Ying-Chang, Kamau, Peter Muiruri, Yang, Lian, Liu, Hong-Qi, Xu, Jing-Wen, Chen, Jie-Kai, Zheng, Yong-Tang, Peng, Xiao-Zhong, Lai, Ren
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 631/535/1267 631/80/304 64/60 82/75 ACE2 Angiotensin Angiotensin-converting enzyme 2 Angiotensin-Converting Enzyme 2 - metabolism Animal models Animals Antibiotics Antiviral Agents - pharmacokinetics Antiviral Agents - pharmacology Biomedical and Life Sciences Blocking Caco-2 Cells Cell Biology Chlorocebus aethiops Clinical trials Coronaviridae Coronaviruses COVID-19 Disease Models, Animal Humans Infections Life Sciences Mice Mice, Transgenic Pandemics Peptidyl-dipeptidase A Protein Binding - drug effects Proteins Replication Respiratory diseases SARS-CoV-2 - metabolism Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus - metabolism Spike protein Teicoplanin - analogs & derivatives Teicoplanin - pharmacokinetics Teicoplanin - pharmacology Vero Cells Viral diseases
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