An ACE2 Microbody Containing a Single Immunoglobulin Fc Domain Is a Potent Inhibitor of SARS-CoV-2

Soluble forms of angiotensin-converting enzyme 2 (ACE2) have recently been shown to inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We report on an improved soluble ACE2, termed a “microbody,” in which the ACE2 ectodomain is fused to Fc domain 3 of the immunoglobulin...

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Veröffentlicht in:	Cell reports (Cambridge) 2020-12, Vol.33 (12), p.108528-108528, Article 108528
Hauptverfasser:	Tada, Takuya, Fan, Chen, Chen, Jennifer S., Kaur, Ramanjit, Stapleford, Kenneth A., Gristick, Harry, Dcosta, Belinda M., Wilen, Craig B., Nimigean, Crina M., Landau, Nathaniel R.
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE2 transgenic Amino Acid Sequence Angiotensin-Converting Enzyme 2 - metabolism Animals Antiviral Agents - pharmacology coronavirus COVID-19 - prevention & control COVID-19 - virology D614G Disease Models, Animal Disulfides - metabolism entry inhibitor Fc fusion Female HEK293 Cells Humans Immunoglobulin Fc Fragments - metabolism lentiviral pseudotype Male Mice, Transgenic Microbodies - metabolism microbody Protein Domains Protein Multimerization SARS-CoV-2 SARS-CoV-2 - drug effects SARS-CoV-2 - pathogenicity soluble ACE2 Spike Glycoprotein, Coronavirus - chemistry Spike Glycoprotein, Coronavirus - metabolism spike protein Virion - metabolism Virus Internalization - drug effects
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