Topical delivery of a small molecule RUNX1 transcription factor inhibitor for the treatment of proliferative vitreoretinopathy

Proliferative vitreoretinopathy (PVR) is the leading cause of retinal detachment surgery failure. Despite significant advances in vitreoretinal surgery, it still remains without an effective prophylactic or therapeutic medical treatment. After ocular injury or retinal detachment, misplaced retinal c...

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Veröffentlicht in:	Scientific reports 2020-11, Vol.10 (1), p.20554, Article 20554
Hauptverfasser:	Delgado-Tirado, Santiago, Amarnani, Dhanesh, Zhao, Guannan, Rossin, Elizabeth J., Eliott, Dean, Miller, John B., Greene, Whitney A., Ramos, Leslie, Arevalo-Alquichire, Said, Leyton-Cifuentes, David, Gonzalez-Buendia, Lucia, Isaacs-Bernal, Daniela, Whitmore, Hannah A. B., Chmielewska, Natalia, Duffy, Brandon V., Kim, Eric, Wang, Heuy-Ching, Ruiz-Moreno, Jose M., Kim, Leo A., Arboleda-Velasquez, Joseph F.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154 631/61 631/80 692/308 Adult Aged Animals Cell proliferation Contractility Core Binding Factor Alpha 2 Subunit - antagonists & inhibitors Core Binding Factor Alpha 2 Subunit - biosynthesis Disease Models, Animal Emulsions Epithelial-Mesenchymal Transition - drug effects Eye Female Gene Expression Regulation - drug effects Humanities and Social Sciences Humans Lipophilic Male Mass spectrometry Mass spectroscopy Medical treatment Mesenchyme multidisciplinary Rabbits Retina Retinal detachment Runx1 protein Science Science (multidisciplinary) Surgery Transcription factors Vitreoretinopathy, Proliferative - drug therapy Vitreoretinopathy, Proliferative - metabolism Vitreoretinopathy, Proliferative - pathology
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