Granulocytes act as a niche for Mycobacterium tuberculosis growth

Granulocyte recruitment to the pulmonary compartment is a hallmark of progressive tuberculosis (TB). This process is well-documented to promote immunopathology, but can also enhance the replication of the pathogen. Both the specific granulocytes responsible for increasing mycobacterial burden and th...

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Veröffentlicht in:	Mucosal immunology 2021-01, Vol.14 (1), p.229-241
Hauptverfasser:	Lovewell, Rustin R., Baer, Christina E., Mishra, Bibhuti B., Smith, Clare M., Sassetti, Christopher M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Allergology Animals Antibodies Bacterial Load Biomarkers Biomedical and Life Sciences Biomedicine Chemotaxis, Leukocyte - immunology Cytokines - metabolism Disease Susceptibility Gastroenterology Gene Expression Profiling Granulocytes Granulocytes - immunology Granulocytes - metabolism Host-Pathogen Interactions - immunology Immune response Immunology Immunomodulation Immunophenotyping Inflammation Inflammation Mediators - metabolism Leukocytes (granulocytic) Lymphocyte Depletion Lymphocytes T Macrophages Mice Mice, Knockout Monocytes Mycobacterium tuberculosis - immunology Replication Severity of Illness Index Tuberculosis Tuberculosis - diagnosis Tuberculosis - immunology Tuberculosis - metabolism Tuberculosis - microbiology
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