Catechol-O-methyltransferase genotype differentially contributes to the flexibility and stability of cognitive sets in patients with psychotic disorders and their first-degree relatives

Dopaminergic activity in prefrontal cortex is modulated by the low (Met) and high (Val) activity of the rs4680 Val158Met single nucleotide polymorphism (SNP) in the Catechol-O-Methyltransferase (COMT) gene. While this has been related to working memory maintenance in patients with schizophrenia, the...

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Veröffentlicht in:	Schizophrenia research 2020-09, Vol.223, p.236-241
Hauptverfasser:	Hochberger, William C., Eskridge, Courtney L.M., Bishop, Jeffrey R., Reilly, James L., Rubin, Leah H., Keedy, Sarah, Gershon, Elliot S., Tamminga, Carol A., Pearlson, Godfrey D., Ragozzino, Michael, Keshavan, Matcheri S., Sweeney, John A., Hill, S. Kristian
Format:	Artikel
Sprache:	eng
Schlagworte:	B-SNIP 1 Catechol-O-methyltransferase (COMT) Penn conditional exclusion task (PCET) Psychosis Set shifting
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