Type 1 interferon-dependent repression of NLRC4 and iPLA2 licenses down-regulation of Salmonella flagellin inside macrophages

Inflammasomes have been implicated in the detection and clearance of a variety of bacterial pathogens, but little is known about whether this innate sensing mechanism has any regulatory effect on the expression of stimulatory ligands by the pathogen. During infection with Salmonella and many other p...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-11, Vol.117 (47), p.29811-29822
Hauptverfasser:	Akhade, Ajay Suresh, Atif, Shaikh M., Lakshmi, Bhavana S., Dikshit, Neha, Hughes, Kelly T., Qadri, Ayub, Subramanian, Naeha
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Vesicular Transport - genetics Adaptor Proteins, Vesicular Transport - metabolism Animals Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism Biological Sciences Calcium-Binding Proteins - genetics Calcium-Binding Proteins - metabolism Cell death Cells, Cultured Crosstalk Disease Models, Animal Down-Regulation Flagellin Flagellin - immunology Flagellin - metabolism Group VI Phospholipases A2 - antagonists & inhibitors Group VI Phospholipases A2 - metabolism Humans Immune clearance Immune system Immunity, Innate Immunomodulation Infections Inflammasomes Inflammasomes - drug effects Inflammasomes - immunology Inflammasomes - metabolism Interferon Interferon Type I - metabolism Ketones - administration & dosage Ligands Lipopolysaccharides - administration & dosage Lipopolysaccharides - immunology Lysophospholipids - metabolism Macrophages Macrophages - drug effects Macrophages - immunology Macrophages - metabolism Mice Mice, Knockout Microorganisms Naphthalenes - administration & dosage Pathogens Phenotypes Phospholipase A2 Primary Cell Culture Proteins Pyroptosis Pyroptosis - immunology Salmonella Salmonella Infections - immunology Salmonella Infections - microbiology Salmonella typhimurium - immunology Salmonella typhimurium - isolation & purification Signal Transduction - drug effects Signal Transduction - immunology Signaling Switches
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