Fragment-derived modulators of an industrial β-glucosidase

A fragment screen of a library of 560 commercially available fragments using a kinetic assay identified a small molecule that increased the activity of the fungal glycoside hydrolase TrBgl2. An analogue by catalogue approach and detailed kinetic analysis identified improved compounds that behaved as...

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Veröffentlicht in:	Biochemical journal 2020-11, Vol.477 (22), p.4383-4395
Hauptverfasser:	Makraki, Eleni, Darby, John F, Carneiro, Marta G, Firth, James D, Heyam, Alex, Ab, Eiso, O'Brien, Peter, Siegal, Gregg, Hubbard, Roderick E
Format:	Artikel
Sprache:	eng
Schlagworte:	beta-Glucosidase - chemistry Biochemical Techniques & Resources Bioinformatics Biophysics Chemical Biology Enzyme Activators - chemistry Fungal Proteins - chemistry Hypocreales - chemistry Nuclear Magnetic Resonance, Biomolecular Structural Biology
Online-Zugang:	Volltext
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