EBV–encoded miRNAs can sensitize nasopharyngeal carcinoma to chemotherapeutic drugs by targeting BRCA1

Nasopharyngeal carcinoma (NPC) is an Epstein‐Barr virus (EBV)‐associated epithelial malignancy. The high expression of BART‐miRNAs (miR‐BARTs) during latent EBV infection in NPC strongly supports their pathological importance in cancer progression. Recently, we found that several BART‐miRNAs work co...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2020-11, Vol.24 (22), p.13523-13535
Hauptverfasser:	Lung, Raymond Wai‐Ming, Tong, Joanna Hung‐Man, Ip, Lok‐Man, Lam, Ka‐Hei, Chan, Anthony Wing‐Hung, Chak, Wing‐Po, Chung, Lau‐Ying, Yeung, Walter Wai, Hau, Pok‐Man, Chau, Shuk‐Ling, Tsao, Sai‐Wah, Lau, Kin‐Mang, Lo, Kwok‐Wai, To, Ka‐Fai
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ataxia telangiectasia Ataxia telangiectasia mutated protein Binding sites BRCA1 BRCA1 protein BRCA1 Protein - genetics BRCA1 Protein - metabolism Cell cycle Cell Cycle - genetics Cell Line, Tumor Cisplatin Deoxyribonucleic acid DNA DNA damage DNA repair Doxorubicin Drug delivery Drug Resistance, Neoplasm - genetics Ectopic expression Epithelial cells Epstein-Barr virus Epstein-Barr Virus Infections - complications Epstein-Barr Virus Infections - virology Gene Expression Regulation, Neoplastic Genes, Reporter Genomes Herpesvirus 4, Human - genetics Host-Pathogen Interactions - genetics Humans Immunohistochemistry Malignancy Mice MicroRNAs miR‐BARTs Mutation Nasopharyngeal carcinoma Nasopharyngeal Carcinoma - drug therapy Nasopharyngeal Carcinoma - etiology Nasopharyngeal Carcinoma - pathology Nasopharyngeal Neoplasms - drug therapy Nasopharyngeal Neoplasms - etiology Nasopharyngeal Neoplasms - pathology Original Plasmids Proteins RNA Interference RNA, Viral Throat cancer
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