Potential effects of SARS-CoV-2 on the gastrointestinal tract and liver
COVID-19 is a pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Early reported symptoms include fever, cough, and respiratory symptoms. There were few reports of digestive symptoms. However, with COVID-19 spreading worldwide, symptoms such as vomiting, diarrhoea, and a...
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| Veröffentlicht in: | Biomedicine & pharmacotherapy 2021-01, Vol.133, p.111064-111064, Article 111064 |
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| creator | Lei, Han-Yu Ding, Ying-He Nie, Kai Dong, Yin-Miao Xu, Jia-Hao Yang, Meng-Ling Liu, Meng-Qi Wei, Le Nasser, MI Xu, Lin-Yong Zhu, Ping Zhao, Ming-Yi |
| description | COVID-19 is a pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Early reported symptoms include fever, cough, and respiratory symptoms. There were few reports of digestive symptoms. However, with COVID-19 spreading worldwide, symptoms such as vomiting, diarrhoea, and abdominal pain have gained increasing attention. Research has found that angiotensin-converting enzyme 2 (ACE2), the SARS-CoV-2 receptor, is strongly expressed in the gastrointestinal tract and liver. Whether theoretically or clinically, many studies have suggested a close connection between COVID-19 and the digestive system. In this review, we summarize the digestive symptoms reported in existing research, discuss the impact of SARS-CoV-2 on the gastrointestinal tract and liver, and determine the possible mechanisms and aetiology, such as cytokine storm. In-depth exploration of the relationship between COVID-19 and the digestive system is urgently needed. |
| doi_str_mv | 10.1016/j.biopha.2020.111064 |
| format | Article |
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Early reported symptoms include fever, cough, and respiratory symptoms. There were few reports of digestive symptoms. However, with COVID-19 spreading worldwide, symptoms such as vomiting, diarrhoea, and abdominal pain have gained increasing attention. Research has found that angiotensin-converting enzyme 2 (ACE2), the SARS-CoV-2 receptor, is strongly expressed in the gastrointestinal tract and liver. Whether theoretically or clinically, many studies have suggested a close connection between COVID-19 and the digestive system. In this review, we summarize the digestive symptoms reported in existing research, discuss the impact of SARS-CoV-2 on the gastrointestinal tract and liver, and determine the possible mechanisms and aetiology, such as cytokine storm. In-depth exploration of the relationship between COVID-19 and the digestive system is urgently needed.</description><identifier>ISSN: 0753-3322</identifier><identifier>ISSN: 1950-6007</identifier><identifier>EISSN: 1950-6007</identifier><identifier>DOI: 10.1016/j.biopha.2020.111064</identifier><identifier>PMID: 33378966</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Angiotensin-Converting Enzyme 2 - metabolism ; Anorexia - etiology ; Antiviral Agents - adverse effects ; Bile Ducts - metabolism ; Bile Ducts - virology ; Chemical and Drug Induced Liver Injury - etiology ; Comorbidity ; COVID-19 ; COVID-19 - complications ; COVID-19 - epidemiology ; COVID-19 - immunology ; COVID-19 - pathology ; Cytokine Release Syndrome - etiology ; Cytopathogenic Effect, Viral ; Gastrointestinal Diseases - epidemiology ; Gastrointestinal Diseases - etiology ; Gastrointestinal Microbiome ; Gastrointestinal tract ; Gastrointestinal Tract - metabolism ; Gastrointestinal Tract - pathology ; Gastrointestinal Tract - virology ; Gut-lung axis ; Humans ; Immunosuppressive Agents - adverse effects ; Inflammatory cytokine storm ; Liver - metabolism ; Liver - pathology ; Liver - virology ; Liver Diseases - epidemiology ; Liver Diseases - etiology ; Liver injury ; Liver transplant ; Liver Transplantation ; Non-alcoholic Fatty Liver Disease - etiology ; Non-alcoholic Fatty Liver Disease - pathology ; Non-alcoholic Fatty Liver Disease - virology ; Pandemics ; Postoperative Complications ; Receptors, Virus - metabolism ; Review ; SARS-CoV-2 - pathogenicity</subject><ispartof>Biomedicine & pharmacotherapy, 2021-01, Vol.133, p.111064-111064, Article 111064</ispartof><rights>2020</rights><rights>Copyright © 2020. Published by Elsevier Masson SAS.</rights><rights>2020 Published by Elsevier Masson SAS. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c529t-dde7a33c448a57d1c2ac7393e2ba1df706c6157f8254111fde70a66533585d623</citedby><cites>FETCH-LOGICAL-c529t-dde7a33c448a57d1c2ac7393e2ba1df706c6157f8254111fde70a66533585d623</cites><orcidid>0000-0002-9890-3958</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0753332220312567$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33378966$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lei, Han-Yu</creatorcontrib><creatorcontrib>Ding, Ying-He</creatorcontrib><creatorcontrib>Nie, Kai</creatorcontrib><creatorcontrib>Dong, Yin-Miao</creatorcontrib><creatorcontrib>Xu, Jia-Hao</creatorcontrib><creatorcontrib>Yang, Meng-Ling</creatorcontrib><creatorcontrib>Liu, Meng-Qi</creatorcontrib><creatorcontrib>Wei, Le</creatorcontrib><creatorcontrib>Nasser, MI</creatorcontrib><creatorcontrib>Xu, Lin-Yong</creatorcontrib><creatorcontrib>Zhu, Ping</creatorcontrib><creatorcontrib>Zhao, Ming-Yi</creatorcontrib><title>Potential effects of SARS-CoV-2 on the gastrointestinal tract and liver</title><title>Biomedicine & pharmacotherapy</title><addtitle>Biomed Pharmacother</addtitle><description>COVID-19 is a pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Early reported symptoms include fever, cough, and respiratory symptoms. There were few reports of digestive symptoms. However, with COVID-19 spreading worldwide, symptoms such as vomiting, diarrhoea, and abdominal pain have gained increasing attention. Research has found that angiotensin-converting enzyme 2 (ACE2), the SARS-CoV-2 receptor, is strongly expressed in the gastrointestinal tract and liver. Whether theoretically or clinically, many studies have suggested a close connection between COVID-19 and the digestive system. In this review, we summarize the digestive symptoms reported in existing research, discuss the impact of SARS-CoV-2 on the gastrointestinal tract and liver, and determine the possible mechanisms and aetiology, such as cytokine storm. In-depth exploration of the relationship between COVID-19 and the digestive system is urgently needed.</description><subject>Angiotensin-Converting Enzyme 2 - metabolism</subject><subject>Anorexia - etiology</subject><subject>Antiviral Agents - adverse effects</subject><subject>Bile Ducts - metabolism</subject><subject>Bile Ducts - virology</subject><subject>Chemical and Drug Induced Liver Injury - etiology</subject><subject>Comorbidity</subject><subject>COVID-19</subject><subject>COVID-19 - complications</subject><subject>COVID-19 - epidemiology</subject><subject>COVID-19 - immunology</subject><subject>COVID-19 - pathology</subject><subject>Cytokine Release Syndrome - etiology</subject><subject>Cytopathogenic Effect, Viral</subject><subject>Gastrointestinal Diseases - epidemiology</subject><subject>Gastrointestinal Diseases - etiology</subject><subject>Gastrointestinal Microbiome</subject><subject>Gastrointestinal tract</subject><subject>Gastrointestinal Tract - metabolism</subject><subject>Gastrointestinal Tract - pathology</subject><subject>Gastrointestinal Tract - virology</subject><subject>Gut-lung axis</subject><subject>Humans</subject><subject>Immunosuppressive Agents - adverse effects</subject><subject>Inflammatory cytokine storm</subject><subject>Liver - metabolism</subject><subject>Liver - pathology</subject><subject>Liver - virology</subject><subject>Liver Diseases - epidemiology</subject><subject>Liver Diseases - etiology</subject><subject>Liver injury</subject><subject>Liver transplant</subject><subject>Liver Transplantation</subject><subject>Non-alcoholic Fatty Liver Disease - etiology</subject><subject>Non-alcoholic Fatty Liver Disease - pathology</subject><subject>Non-alcoholic Fatty Liver Disease - virology</subject><subject>Pandemics</subject><subject>Postoperative Complications</subject><subject>Receptors, Virus - metabolism</subject><subject>Review</subject><subject>SARS-CoV-2 - pathogenicity</subject><issn>0753-3322</issn><issn>1950-6007</issn><issn>1950-6007</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UdtKAzEQDaJorf6ByD76sjWXTbL7IkjxBoLi7TWkyaxN2W5qkhb8e1Pq9cWngZkz58yZg9ARwSOCiTidjSbOL6Z6RDHNLUKwqLbQgDQclwJjuY0GWHJWMkbpHtqPcYYx5oLVu2iPMSbrRogBurr3CfrkdFdA24JJsfBt8Xj-8FiO_UtJC98XaQrFq44peNcniMn1GZ2CNqnQvS06t4JwgHZa3UU4_KxD9Hx58TS-Lm_vrm7G57el4bRJpbUgNWOmqmrNpSWGaiNZw4BONLGtxMIIwmVbU15lS22GYy0EZ4zX3ArKhuhsw7tYTuZgTb496E4tgpvr8K68durvpHdT9epXSspsn5BMcPJJEPzbMrtRcxcNdJ3uwS-jopWsqkaSrDlE1QZqgo8xQPstQ7BaZ6BmapOBWmegNhnktePfJ34vfT39xwPkR60cBBWNg96AdSEnoKx3_yt8ADUGmUs</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Lei, Han-Yu</creator><creator>Ding, Ying-He</creator><creator>Nie, Kai</creator><creator>Dong, Yin-Miao</creator><creator>Xu, Jia-Hao</creator><creator>Yang, Meng-Ling</creator><creator>Liu, Meng-Qi</creator><creator>Wei, Le</creator><creator>Nasser, MI</creator><creator>Xu, Lin-Yong</creator><creator>Zhu, Ping</creator><creator>Zhao, Ming-Yi</creator><general>Elsevier Masson SAS</general><general>Published by Elsevier Masson SAS</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9890-3958</orcidid></search><sort><creationdate>20210101</creationdate><title>Potential effects of SARS-CoV-2 on the gastrointestinal tract and liver</title><author>Lei, Han-Yu ; Ding, Ying-He ; Nie, Kai ; Dong, Yin-Miao ; Xu, Jia-Hao ; Yang, Meng-Ling ; Liu, Meng-Qi ; Wei, Le ; Nasser, MI ; Xu, Lin-Yong ; Zhu, Ping ; Zhao, Ming-Yi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c529t-dde7a33c448a57d1c2ac7393e2ba1df706c6157f8254111fde70a66533585d623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Angiotensin-Converting Enzyme 2 - metabolism</topic><topic>Anorexia - etiology</topic><topic>Antiviral Agents - adverse effects</topic><topic>Bile Ducts - metabolism</topic><topic>Bile Ducts - virology</topic><topic>Chemical and Drug Induced Liver Injury - etiology</topic><topic>Comorbidity</topic><topic>COVID-19</topic><topic>COVID-19 - complications</topic><topic>COVID-19 - epidemiology</topic><topic>COVID-19 - immunology</topic><topic>COVID-19 - pathology</topic><topic>Cytokine Release Syndrome - etiology</topic><topic>Cytopathogenic Effect, Viral</topic><topic>Gastrointestinal Diseases - epidemiology</topic><topic>Gastrointestinal Diseases - etiology</topic><topic>Gastrointestinal Microbiome</topic><topic>Gastrointestinal tract</topic><topic>Gastrointestinal Tract - metabolism</topic><topic>Gastrointestinal Tract - pathology</topic><topic>Gastrointestinal Tract - virology</topic><topic>Gut-lung axis</topic><topic>Humans</topic><topic>Immunosuppressive Agents - adverse effects</topic><topic>Inflammatory cytokine storm</topic><topic>Liver - metabolism</topic><topic>Liver - pathology</topic><topic>Liver - virology</topic><topic>Liver Diseases - epidemiology</topic><topic>Liver Diseases - etiology</topic><topic>Liver injury</topic><topic>Liver transplant</topic><topic>Liver Transplantation</topic><topic>Non-alcoholic Fatty Liver Disease - etiology</topic><topic>Non-alcoholic Fatty Liver Disease - pathology</topic><topic>Non-alcoholic Fatty Liver Disease - virology</topic><topic>Pandemics</topic><topic>Postoperative Complications</topic><topic>Receptors, Virus - metabolism</topic><topic>Review</topic><topic>SARS-CoV-2 - pathogenicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lei, Han-Yu</creatorcontrib><creatorcontrib>Ding, Ying-He</creatorcontrib><creatorcontrib>Nie, Kai</creatorcontrib><creatorcontrib>Dong, Yin-Miao</creatorcontrib><creatorcontrib>Xu, Jia-Hao</creatorcontrib><creatorcontrib>Yang, Meng-Ling</creatorcontrib><creatorcontrib>Liu, Meng-Qi</creatorcontrib><creatorcontrib>Wei, Le</creatorcontrib><creatorcontrib>Nasser, MI</creatorcontrib><creatorcontrib>Xu, Lin-Yong</creatorcontrib><creatorcontrib>Zhu, Ping</creatorcontrib><creatorcontrib>Zhao, Ming-Yi</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biomedicine & pharmacotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lei, Han-Yu</au><au>Ding, Ying-He</au><au>Nie, Kai</au><au>Dong, Yin-Miao</au><au>Xu, Jia-Hao</au><au>Yang, Meng-Ling</au><au>Liu, Meng-Qi</au><au>Wei, Le</au><au>Nasser, MI</au><au>Xu, Lin-Yong</au><au>Zhu, Ping</au><au>Zhao, Ming-Yi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potential effects of SARS-CoV-2 on the gastrointestinal tract and liver</atitle><jtitle>Biomedicine & pharmacotherapy</jtitle><addtitle>Biomed Pharmacother</addtitle><date>2021-01-01</date><risdate>2021</risdate><volume>133</volume><spage>111064</spage><epage>111064</epage><pages>111064-111064</pages><artnum>111064</artnum><issn>0753-3322</issn><issn>1950-6007</issn><eissn>1950-6007</eissn><abstract>COVID-19 is a pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Early reported symptoms include fever, cough, and respiratory symptoms. There were few reports of digestive symptoms. However, with COVID-19 spreading worldwide, symptoms such as vomiting, diarrhoea, and abdominal pain have gained increasing attention. Research has found that angiotensin-converting enzyme 2 (ACE2), the SARS-CoV-2 receptor, is strongly expressed in the gastrointestinal tract and liver. Whether theoretically or clinically, many studies have suggested a close connection between COVID-19 and the digestive system. In this review, we summarize the digestive symptoms reported in existing research, discuss the impact of SARS-CoV-2 on the gastrointestinal tract and liver, and determine the possible mechanisms and aetiology, such as cytokine storm. In-depth exploration of the relationship between COVID-19 and the digestive system is urgently needed.</abstract><cop>France</cop><pub>Elsevier Masson SAS</pub><pmid>33378966</pmid><doi>10.1016/j.biopha.2020.111064</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-9890-3958</orcidid><oa>free_for_read</oa></addata></record> |
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| issn | 0753-3322 1950-6007 1950-6007 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Angiotensin-Converting Enzyme 2 - metabolism Anorexia - etiology Antiviral Agents - adverse effects Bile Ducts - metabolism Bile Ducts - virology Chemical and Drug Induced Liver Injury - etiology Comorbidity COVID-19 COVID-19 - complications COVID-19 - epidemiology COVID-19 - immunology COVID-19 - pathology Cytokine Release Syndrome - etiology Cytopathogenic Effect, Viral Gastrointestinal Diseases - epidemiology Gastrointestinal Diseases - etiology Gastrointestinal Microbiome Gastrointestinal tract Gastrointestinal Tract - metabolism Gastrointestinal Tract - pathology Gastrointestinal Tract - virology Gut-lung axis Humans Immunosuppressive Agents - adverse effects Inflammatory cytokine storm Liver - metabolism Liver - pathology Liver - virology Liver Diseases - epidemiology Liver Diseases - etiology Liver injury Liver transplant Liver Transplantation Non-alcoholic Fatty Liver Disease - etiology Non-alcoholic Fatty Liver Disease - pathology Non-alcoholic Fatty Liver Disease - virology Pandemics Postoperative Complications Receptors, Virus - metabolism Review SARS-CoV-2 - pathogenicity |
| title | Potential effects of SARS-CoV-2 on the gastrointestinal tract and liver |
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