Comprehensive Genomic Profile of Heterogeneous Long Follow-Up Triple-Negative Breast Cancer and Its Clinical Characteristics Shows DNA Repair Deficiency Has Better Prognostic

Triple-negative breast cancer (TNBC) presents a marked diversity at the molecular level, which promotes a clinical heterogeneity that further complicates treatment. We performed a detailed whole exome sequencing profile of 29 Mexican patients with long follow-up TNBC to identify genomic alterations...

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Veröffentlicht in:	Genes 2020-11, Vol.11 (11), p.1367
Hauptverfasser:	Rojas-Jiménez, Ernesto, Mejía-Gómez, Javier César, Díaz-Velásquez, Clara, Quezada-Urban, Rosalía, Martínez Gregorio, Héctor, Vallejo-Lecuona, Fernando, de la Cruz-Montoya, Aldo, Porras Reyes, Fany Iris, Pérez-Sánchez, Víctor Manuel, Maldonado-Martínez, Héctor Aquiles, Robles-Estrada, Maybelline, Bargalló-Rocha, Enrique, Cabrera-Galeana, Paula, Ramos-Ramírez, Maritza, Chirino, Yolanda Irasema, Alonso Herrera, Luis, Terrazas, Luis Ignacio, Oliver, Javier, Frecha, Cecilia, Perdomo, Sandra, Vaca-Paniagua, Felipe
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged BRCA1 protein Breast cancer Cancer therapies Chemotherapy Deoxyribonucleic acid DNA DNA repair DNA Repair-Deficiency Disorders - genetics DNA sequencing Exome Sequencing Female Genetic aspects Genomes Health aspects Humans Kaplan-Meier Estimate Lymphocytes, Tumor-Infiltrating - pathology Medical prognosis Methods Middle Aged Mutation Nucleotide sequencing p53 Protein Pathology Patients Platinum PTEN protein Salts Survival Survival analysis Triple Negative Breast Neoplasms - drug therapy Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - mortality Triple Negative Breast Neoplasms - pathology Tumors
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