The ECETOC-Targeted Risk Assessment Tool for Worker Exposure Estimation in REACH Registration Dossiers of Chemical Substances-Current Developments
(1) Background: The ECETOC Targeted Risk Assessment (TRA) tool is widely used for estimation of worker exposure levels in the development of dossiers for REACH registration of manufactured or imported chemical substances in Europe. A number of studies have been published since 2010 in which the expo...
Gespeichert in:
| Veröffentlicht in: | International journal of environmental research and public health 2020-11, Vol.17 (22), p.8443 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 22 |
| container_start_page | 8443 |
| container_title | International journal of environmental research and public health |
| container_volume | 17 |
| creator | Urbanus, Jan Henschel, Oliver Li, Qiang Marsh, Dave Money, Chris Noij, Dook van de Sandt, Paul van Rooij, Joost Wormuth, Matthias |
| description | (1) Background: The ECETOC Targeted Risk Assessment (TRA) tool is widely used for estimation of worker exposure levels in the development of dossiers for REACH registration of manufactured or imported chemical substances in Europe. A number of studies have been published since 2010 in which the exposure estimates of the tool are compared with workplace exposure measurement results and in some instances an underestimation of exposure was reported. The quality and results of these studies are being reviewed by ECETOC. (2) Methods: Original exposure measurement data from published comparison studies for which six or more data points were available for each workplace scenario and a TRA estimate had been developed to create a curated database to examine under what conditions and for which applications the tool is valid or may need adaptation. (3) Results: The published studies have been reviewed for completeness and clarity and TRA estimates have been constructed based on the available information, following a set of rules. The full review findings are expected to be available in the course of 2021. (4) Conclusions: The ECETOC TRA tool developers periodically review the validity and limitations of their tool, in line with international recommendations. |
| doi_str_mv | 10.3390/ijerph17228443 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7697447</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2462181598</sourcerecordid><originalsourceid>FETCH-LOGICAL-c418t-944c6399253553cee16b275124bc05d444b70451b5362811a871bbdd5ab5db883</originalsourceid><addsrcrecordid>eNpVkU9v1DAQxSMEoqVw5YgscU7x_zgXpFUaKFKlSksQR8tOZne9zcbBk1TwNfjEZLWlak-2PDPv98Yvy94zeilEST-FPaRxxwrOjZTiRXbOtKa51JS9fHI_y94g7ikVRurydXYmBKdcG3We_W12QOqqbm6rvHFpCxN0ZB3wjqwQAfEAw0SaGHuyiYn8jOkOEql_jxHntAziFA5uCnEgYSDrelVdkzVsA07p9HoVEQMkJHFDqh0cQut68n32OLmhBcyrOaUj4QruoY_jkYZvs1cb1yO8ezgvsh9f6qa6zm9uv36rVjd5K5mZ8lLKVouy5EooJVoApj0vFOPSt1R1UkpfUKmYV0Jzw5gzBfO-65TzqvPGiIvs80l3nP0BunZhJ9fbMS0rpT82umCfV4aws9t4bwtdFlIWi8DHB4EUf82Ak93HOQ2LZ8ul5swwVR4xl6euNi2fkWDzSGDUHjO0zzNcBj489fXY_j808Q9mcJqk</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2462181598</pqid></control><display><type>article</type><title>The ECETOC-Targeted Risk Assessment Tool for Worker Exposure Estimation in REACH Registration Dossiers of Chemical Substances-Current Developments</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>PubMed Central Open Access</source><creator>Urbanus, Jan ; Henschel, Oliver ; Li, Qiang ; Marsh, Dave ; Money, Chris ; Noij, Dook ; van de Sandt, Paul ; van Rooij, Joost ; Wormuth, Matthias</creator><creatorcontrib>Urbanus, Jan ; Henschel, Oliver ; Li, Qiang ; Marsh, Dave ; Money, Chris ; Noij, Dook ; van de Sandt, Paul ; van Rooij, Joost ; Wormuth, Matthias</creatorcontrib><description>(1) Background: The ECETOC Targeted Risk Assessment (TRA) tool is widely used for estimation of worker exposure levels in the development of dossiers for REACH registration of manufactured or imported chemical substances in Europe. A number of studies have been published since 2010 in which the exposure estimates of the tool are compared with workplace exposure measurement results and in some instances an underestimation of exposure was reported. The quality and results of these studies are being reviewed by ECETOC. (2) Methods: Original exposure measurement data from published comparison studies for which six or more data points were available for each workplace scenario and a TRA estimate had been developed to create a curated database to examine under what conditions and for which applications the tool is valid or may need adaptation. (3) Results: The published studies have been reviewed for completeness and clarity and TRA estimates have been constructed based on the available information, following a set of rules. The full review findings are expected to be available in the course of 2021. (4) Conclusions: The ECETOC TRA tool developers periodically review the validity and limitations of their tool, in line with international recommendations.</description><identifier>ISSN: 1660-4601</identifier><identifier>ISSN: 1661-7827</identifier><identifier>EISSN: 1660-4601</identifier><identifier>DOI: 10.3390/ijerph17228443</identifier><identifier>PMID: 33202685</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Chemicals ; Communication ; Data points ; Datasets ; Deadlines ; Environmental Exposure - adverse effects ; Estimates ; Europe ; Exposure ; Occupational Exposure ; Registration ; Regulation ; Regulatory agencies ; Reviews ; Risk assessment ; Risk Assessment - methods ; Supply chains ; Validation studies ; Ventilation</subject><ispartof>International journal of environmental research and public health, 2020-11, Vol.17 (22), p.8443</ispartof><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-944c6399253553cee16b275124bc05d444b70451b5362811a871bbdd5ab5db883</citedby><cites>FETCH-LOGICAL-c418t-944c6399253553cee16b275124bc05d444b70451b5362811a871bbdd5ab5db883</cites><orcidid>0000-0002-2428-5915</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697447/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697447/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33202685$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Urbanus, Jan</creatorcontrib><creatorcontrib>Henschel, Oliver</creatorcontrib><creatorcontrib>Li, Qiang</creatorcontrib><creatorcontrib>Marsh, Dave</creatorcontrib><creatorcontrib>Money, Chris</creatorcontrib><creatorcontrib>Noij, Dook</creatorcontrib><creatorcontrib>van de Sandt, Paul</creatorcontrib><creatorcontrib>van Rooij, Joost</creatorcontrib><creatorcontrib>Wormuth, Matthias</creatorcontrib><title>The ECETOC-Targeted Risk Assessment Tool for Worker Exposure Estimation in REACH Registration Dossiers of Chemical Substances-Current Developments</title><title>International journal of environmental research and public health</title><addtitle>Int J Environ Res Public Health</addtitle><description>(1) Background: The ECETOC Targeted Risk Assessment (TRA) tool is widely used for estimation of worker exposure levels in the development of dossiers for REACH registration of manufactured or imported chemical substances in Europe. A number of studies have been published since 2010 in which the exposure estimates of the tool are compared with workplace exposure measurement results and in some instances an underestimation of exposure was reported. The quality and results of these studies are being reviewed by ECETOC. (2) Methods: Original exposure measurement data from published comparison studies for which six or more data points were available for each workplace scenario and a TRA estimate had been developed to create a curated database to examine under what conditions and for which applications the tool is valid or may need adaptation. (3) Results: The published studies have been reviewed for completeness and clarity and TRA estimates have been constructed based on the available information, following a set of rules. The full review findings are expected to be available in the course of 2021. (4) Conclusions: The ECETOC TRA tool developers periodically review the validity and limitations of their tool, in line with international recommendations.</description><subject>Chemicals</subject><subject>Communication</subject><subject>Data points</subject><subject>Datasets</subject><subject>Deadlines</subject><subject>Environmental Exposure - adverse effects</subject><subject>Estimates</subject><subject>Europe</subject><subject>Exposure</subject><subject>Occupational Exposure</subject><subject>Registration</subject><subject>Regulation</subject><subject>Regulatory agencies</subject><subject>Reviews</subject><subject>Risk assessment</subject><subject>Risk Assessment - methods</subject><subject>Supply chains</subject><subject>Validation studies</subject><subject>Ventilation</subject><issn>1660-4601</issn><issn>1661-7827</issn><issn>1660-4601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpVkU9v1DAQxSMEoqVw5YgscU7x_zgXpFUaKFKlSksQR8tOZne9zcbBk1TwNfjEZLWlak-2PDPv98Yvy94zeilEST-FPaRxxwrOjZTiRXbOtKa51JS9fHI_y94g7ikVRurydXYmBKdcG3We_W12QOqqbm6rvHFpCxN0ZB3wjqwQAfEAw0SaGHuyiYn8jOkOEql_jxHntAziFA5uCnEgYSDrelVdkzVsA07p9HoVEQMkJHFDqh0cQut68n32OLmhBcyrOaUj4QruoY_jkYZvs1cb1yO8ezgvsh9f6qa6zm9uv36rVjd5K5mZ8lLKVouy5EooJVoApj0vFOPSt1R1UkpfUKmYV0Jzw5gzBfO-65TzqvPGiIvs80l3nP0BunZhJ9fbMS0rpT82umCfV4aws9t4bwtdFlIWi8DHB4EUf82Ak93HOQ2LZ8ul5swwVR4xl6euNi2fkWDzSGDUHjO0zzNcBj489fXY_j808Q9mcJqk</recordid><startdate>20201114</startdate><enddate>20201114</enddate><creator>Urbanus, Jan</creator><creator>Henschel, Oliver</creator><creator>Li, Qiang</creator><creator>Marsh, Dave</creator><creator>Money, Chris</creator><creator>Noij, Dook</creator><creator>van de Sandt, Paul</creator><creator>van Rooij, Joost</creator><creator>Wormuth, Matthias</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2428-5915</orcidid></search><sort><creationdate>20201114</creationdate><title>The ECETOC-Targeted Risk Assessment Tool for Worker Exposure Estimation in REACH Registration Dossiers of Chemical Substances-Current Developments</title><author>Urbanus, Jan ; Henschel, Oliver ; Li, Qiang ; Marsh, Dave ; Money, Chris ; Noij, Dook ; van de Sandt, Paul ; van Rooij, Joost ; Wormuth, Matthias</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-944c6399253553cee16b275124bc05d444b70451b5362811a871bbdd5ab5db883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Chemicals</topic><topic>Communication</topic><topic>Data points</topic><topic>Datasets</topic><topic>Deadlines</topic><topic>Environmental Exposure - adverse effects</topic><topic>Estimates</topic><topic>Europe</topic><topic>Exposure</topic><topic>Occupational Exposure</topic><topic>Registration</topic><topic>Regulation</topic><topic>Regulatory agencies</topic><topic>Reviews</topic><topic>Risk assessment</topic><topic>Risk Assessment - methods</topic><topic>Supply chains</topic><topic>Validation studies</topic><topic>Ventilation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Urbanus, Jan</creatorcontrib><creatorcontrib>Henschel, Oliver</creatorcontrib><creatorcontrib>Li, Qiang</creatorcontrib><creatorcontrib>Marsh, Dave</creatorcontrib><creatorcontrib>Money, Chris</creatorcontrib><creatorcontrib>Noij, Dook</creatorcontrib><creatorcontrib>van de Sandt, Paul</creatorcontrib><creatorcontrib>van Rooij, Joost</creatorcontrib><creatorcontrib>Wormuth, Matthias</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of environmental research and public health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Urbanus, Jan</au><au>Henschel, Oliver</au><au>Li, Qiang</au><au>Marsh, Dave</au><au>Money, Chris</au><au>Noij, Dook</au><au>van de Sandt, Paul</au><au>van Rooij, Joost</au><au>Wormuth, Matthias</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The ECETOC-Targeted Risk Assessment Tool for Worker Exposure Estimation in REACH Registration Dossiers of Chemical Substances-Current Developments</atitle><jtitle>International journal of environmental research and public health</jtitle><addtitle>Int J Environ Res Public Health</addtitle><date>2020-11-14</date><risdate>2020</risdate><volume>17</volume><issue>22</issue><spage>8443</spage><pages>8443-</pages><issn>1660-4601</issn><issn>1661-7827</issn><eissn>1660-4601</eissn><abstract>(1) Background: The ECETOC Targeted Risk Assessment (TRA) tool is widely used for estimation of worker exposure levels in the development of dossiers for REACH registration of manufactured or imported chemical substances in Europe. A number of studies have been published since 2010 in which the exposure estimates of the tool are compared with workplace exposure measurement results and in some instances an underestimation of exposure was reported. The quality and results of these studies are being reviewed by ECETOC. (2) Methods: Original exposure measurement data from published comparison studies for which six or more data points were available for each workplace scenario and a TRA estimate had been developed to create a curated database to examine under what conditions and for which applications the tool is valid or may need adaptation. (3) Results: The published studies have been reviewed for completeness and clarity and TRA estimates have been constructed based on the available information, following a set of rules. The full review findings are expected to be available in the course of 2021. (4) Conclusions: The ECETOC TRA tool developers periodically review the validity and limitations of their tool, in line with international recommendations.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>33202685</pmid><doi>10.3390/ijerph17228443</doi><orcidid>https://orcid.org/0000-0002-2428-5915</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1660-4601 |
| ispartof | International journal of environmental research and public health, 2020-11, Vol.17 (22), p.8443 |
| issn | 1660-4601 1661-7827 1660-4601 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7697447 |
| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; PubMed Central Open Access |
| subjects | Chemicals Communication Data points Datasets Deadlines Environmental Exposure - adverse effects Estimates Europe Exposure Occupational Exposure Registration Regulation Regulatory agencies Reviews Risk assessment Risk Assessment - methods Supply chains Validation studies Ventilation |
| title | The ECETOC-Targeted Risk Assessment Tool for Worker Exposure Estimation in REACH Registration Dossiers of Chemical Substances-Current Developments |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T04%3A31%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20ECETOC-Targeted%20Risk%20Assessment%20Tool%20for%20Worker%20Exposure%20Estimation%20in%20REACH%20Registration%20Dossiers%20of%20Chemical%20Substances-Current%20Developments&rft.jtitle=International%20journal%20of%20environmental%20research%20and%20public%20health&rft.au=Urbanus,%20Jan&rft.date=2020-11-14&rft.volume=17&rft.issue=22&rft.spage=8443&rft.pages=8443-&rft.issn=1660-4601&rft.eissn=1660-4601&rft_id=info:doi/10.3390/ijerph17228443&rft_dat=%3Cproquest_pubme%3E2462181598%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2462181598&rft_id=info:pmid/33202685&rfr_iscdi=true |