Pygenic Acid A (PA) Sensitizes Metastatic Breast Cancer Cells to Anoikis and Inhibits Metastasis In Vivo

Metastasis is the main cause of cancer-related deaths. Anoikis is a type of apoptosis caused by cell detachment, and cancer cells become anoikis resistant such that they survive during circulation and can successfully metastasize. Therefore, sensitization of cancer cells to anoikis could prevent met...

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Veröffentlicht in:	International journal of molecular sciences 2020-11, Vol.21 (22), p.8444, Article 8444
Hauptverfasser:	Lim, Ga-Eun, Sung, Jee Young, Yu, Suyeun, Kim, Younmi, Shim, Jaegal, Kim, Hyo Jung, Cho, Myoung Lae, Lee, Jae-Seon, Kim, Yong-Nyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anoikis Anoikis - drug effects Antineoplastic Agents, Phytogenic - pharmacology Autophagy - drug effects Biochemistry & Molecular Biology breast cancer Caspase 3 - metabolism cell aggregations Cell Line, Tumor Chemistry Chemistry, Multidisciplinary Drug Resistance, Neoplasm Endoplasmic Reticulum Stress - drug effects Female Humans Inhibitor of Apoptosis Proteins - metabolism Life Sciences & Biomedicine Lung Neoplasms - drug therapy Lung Neoplasms - prevention & control Lung Neoplasms - secondary Mammary Neoplasms, Experimental - drug therapy Mammary Neoplasms, Experimental - metabolism Mammary Neoplasms, Experimental - pathology Medicine, East Asian Traditional metastasis Mice Mice, Inbred BALB C Physical Sciences Plants, Medicinal Prunella Science & Technology Signal Transduction - drug effects Triple Negative Breast Neoplasms - drug therapy Triple Negative Breast Neoplasms - metabolism Triple Negative Breast Neoplasms - pathology Triterpenes - pharmacology
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