Assessment of the hepatic tumor extracellular matrix using elastin-specific molecular magnetic resonance imaging in an experimental rabbit cancer model
To investigate the imaging performance of an elastin-specific molecular magnetic resonance imaging (MRI) probe with respect to the extracellular matrix (ECM) in an experimental hepatic cancer model. Twelve rabbits with hepatic VX2 tumors were examined using 3 T MRI 14, 21, and 28 days after tumor im...
Gespeichert in:
| Veröffentlicht in: | Scientific reports 2020-11, Vol.10 (1), p.20785-20785, Article 20785 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 20785 |
|---|---|
| container_issue | 1 |
| container_start_page | 20785 |
| container_title | Scientific reports |
| container_volume | 10 |
| creator | Keller, Sarah Borde, Tabea Brangsch, Julia Reimann, Carolin Kader, Avan Schulze, Daniel Buchholz, Rebecca Kaufmann, Jan O. Karst, Uwe Schellenberger, Eyk Hamm, Bernd Makowski, Marcus R. |
| description | To investigate the imaging performance of an elastin-specific molecular magnetic resonance imaging (MRI) probe with respect to the extracellular matrix (ECM) in an experimental hepatic cancer model. Twelve rabbits with hepatic VX2 tumors were examined using 3 T MRI 14, 21, and 28 days after tumor implantation for two subsequent days (gadobutrol, day 1; elastin-specific probe, day 2). The relative enhancement (RE) of segmented tumor regions (central and margin) and the peritumoral matrix was calculated using pre-contrast and delayed-phase T1w sequences. MRI measurements were correlated to histopathology and element-specific and spatially resolved mass spectrometry (MS). Mixed-model analysis was performed to assess the performance of the elastin-specific probe. In comparison to gadobutrol, the elastin probe showed significantly stronger RE, which was pronounced in the tumor margin (day 14–28:
P
≤ 0.007). In addition, the elastin probe was superior in discriminating between tumor regions (χ
2
(4) = 65.87;
P
|
| doi_str_mv | 10.1038/s41598-020-77624-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7695832</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2465435214</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-f41c2b928a47b6af369712734c66bcec2c51548cb6e2bc7256b4d881dc40f6373</originalsourceid><addsrcrecordid>eNp9kc1u1DAUhSMEolXpC7BAltiwCcTXv9kgVRW0SJXYwNpyPDczrhJ7sB3UPgmvi8MMpbDAG1v2d86916dpXtLuLe2Yfpc5Fb1uO-hapSTwVj9pTqHjogUG8PTR-aQ5z_m2q0tAz2n_vDlhDLiiWpw2Py5yxpxnDIXEkZQdkh3ubfGOlGWOieBdSdbhNC2TTWS2Jfk7smQftgQnm4sPbd6j82NVzHFCd-S2AVeThDkGGxwSX-9WlQ_Ehmq7x-TXsnYiyQ6DL8StXNXGDU4vmmejnTKeH_ez5uvHD18ur9ubz1efLi9uWscVL-3IqYOhB225GqQdmewVBcW4k3Jw6MAJKrh2g0QYnAIhB77Rmm4c70bJFDtr3h9898sw48bVhpKdzL72ZtO9idabv1-C35lt_G6U7IVmUA3eHA1S_LZgLmb2ef0vGzAu2QCXgjMBlFf09T_obVxSqONVSjGgXc9WCg6USzHnhONDM7Qza_TmEL2p0Ztf0RtdRa8ej_Eg-R10BdgByPUpbDH9qf0f259QJ73S</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2473210934</pqid></control><display><type>article</type><title>Assessment of the hepatic tumor extracellular matrix using elastin-specific molecular magnetic resonance imaging in an experimental rabbit cancer model</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Springer Nature OA Free Journals</source><source>Nature Free</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Keller, Sarah ; Borde, Tabea ; Brangsch, Julia ; Reimann, Carolin ; Kader, Avan ; Schulze, Daniel ; Buchholz, Rebecca ; Kaufmann, Jan O. ; Karst, Uwe ; Schellenberger, Eyk ; Hamm, Bernd ; Makowski, Marcus R.</creator><creatorcontrib>Keller, Sarah ; Borde, Tabea ; Brangsch, Julia ; Reimann, Carolin ; Kader, Avan ; Schulze, Daniel ; Buchholz, Rebecca ; Kaufmann, Jan O. ; Karst, Uwe ; Schellenberger, Eyk ; Hamm, Bernd ; Makowski, Marcus R.</creatorcontrib><description>To investigate the imaging performance of an elastin-specific molecular magnetic resonance imaging (MRI) probe with respect to the extracellular matrix (ECM) in an experimental hepatic cancer model. Twelve rabbits with hepatic VX2 tumors were examined using 3 T MRI 14, 21, and 28 days after tumor implantation for two subsequent days (gadobutrol, day 1; elastin-specific probe, day 2). The relative enhancement (RE) of segmented tumor regions (central and margin) and the peritumoral matrix was calculated using pre-contrast and delayed-phase T1w sequences. MRI measurements were correlated to histopathology and element-specific and spatially resolved mass spectrometry (MS). Mixed-model analysis was performed to assess the performance of the elastin-specific probe. In comparison to gadobutrol, the elastin probe showed significantly stronger RE, which was pronounced in the tumor margin (day 14–28:
P
≤ 0.007). In addition, the elastin probe was superior in discriminating between tumor regions (χ
2
(4) = 65.87;
P
< 0.001). MRI-based measurements of the elastin probe significantly correlated with the ex vivo elastinstain (R = .84;
P
<0 .001) and absolute gadolinium concentrations (ICP-MS: R = .73,
P
<0 .01). LA-ICP-MS imaging confirmed the colocalization of the elastin-specific probe with elastic fibers. Elastin-specific molecular MRI is superior to non-specific gadolinium-based contrast agents in imaging the ECM of hepatic tumors and the peritumoral tissue.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-77624-8</identifier><identifier>PMID: 33247185</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/700/1421/1628 ; 692/700/1421/2160 ; Animals ; Cell Line, Tumor ; Contrast Media ; Elastin ; Elastin - metabolism ; Extracellular matrix ; Extracellular Matrix - metabolism ; Extracellular Matrix - pathology ; Female ; Fibers ; Gadolinium ; Histopathology ; Humanities and Social Sciences ; Liver ; Liver cancer ; Liver Neoplasms, Experimental - diagnostic imaging ; Liver Neoplasms, Experimental - metabolism ; Liver Neoplasms, Experimental - pathology ; Magnetic Resonance Imaging ; Mass spectrometry ; Mass spectroscopy ; Molecular Probes ; multidisciplinary ; Organometallic Compounds ; Performance assessment ; Rabbits ; Science ; Science (multidisciplinary) ; Tumors</subject><ispartof>Scientific reports, 2020-11, Vol.10 (1), p.20785-20785, Article 20785</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-f41c2b928a47b6af369712734c66bcec2c51548cb6e2bc7256b4d881dc40f6373</citedby><cites>FETCH-LOGICAL-c474t-f41c2b928a47b6af369712734c66bcec2c51548cb6e2bc7256b4d881dc40f6373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695832/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695832/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27922,27923,41118,42187,51574,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33247185$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Keller, Sarah</creatorcontrib><creatorcontrib>Borde, Tabea</creatorcontrib><creatorcontrib>Brangsch, Julia</creatorcontrib><creatorcontrib>Reimann, Carolin</creatorcontrib><creatorcontrib>Kader, Avan</creatorcontrib><creatorcontrib>Schulze, Daniel</creatorcontrib><creatorcontrib>Buchholz, Rebecca</creatorcontrib><creatorcontrib>Kaufmann, Jan O.</creatorcontrib><creatorcontrib>Karst, Uwe</creatorcontrib><creatorcontrib>Schellenberger, Eyk</creatorcontrib><creatorcontrib>Hamm, Bernd</creatorcontrib><creatorcontrib>Makowski, Marcus R.</creatorcontrib><title>Assessment of the hepatic tumor extracellular matrix using elastin-specific molecular magnetic resonance imaging in an experimental rabbit cancer model</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>To investigate the imaging performance of an elastin-specific molecular magnetic resonance imaging (MRI) probe with respect to the extracellular matrix (ECM) in an experimental hepatic cancer model. Twelve rabbits with hepatic VX2 tumors were examined using 3 T MRI 14, 21, and 28 days after tumor implantation for two subsequent days (gadobutrol, day 1; elastin-specific probe, day 2). The relative enhancement (RE) of segmented tumor regions (central and margin) and the peritumoral matrix was calculated using pre-contrast and delayed-phase T1w sequences. MRI measurements were correlated to histopathology and element-specific and spatially resolved mass spectrometry (MS). Mixed-model analysis was performed to assess the performance of the elastin-specific probe. In comparison to gadobutrol, the elastin probe showed significantly stronger RE, which was pronounced in the tumor margin (day 14–28:
P
≤ 0.007). In addition, the elastin probe was superior in discriminating between tumor regions (χ
2
(4) = 65.87;
P
< 0.001). MRI-based measurements of the elastin probe significantly correlated with the ex vivo elastinstain (R = .84;
P
<0 .001) and absolute gadolinium concentrations (ICP-MS: R = .73,
P
<0 .01). LA-ICP-MS imaging confirmed the colocalization of the elastin-specific probe with elastic fibers. Elastin-specific molecular MRI is superior to non-specific gadolinium-based contrast agents in imaging the ECM of hepatic tumors and the peritumoral tissue.</description><subject>692/700/1421/1628</subject><subject>692/700/1421/2160</subject><subject>Animals</subject><subject>Cell Line, Tumor</subject><subject>Contrast Media</subject><subject>Elastin</subject><subject>Elastin - metabolism</subject><subject>Extracellular matrix</subject><subject>Extracellular Matrix - metabolism</subject><subject>Extracellular Matrix - pathology</subject><subject>Female</subject><subject>Fibers</subject><subject>Gadolinium</subject><subject>Histopathology</subject><subject>Humanities and Social Sciences</subject><subject>Liver</subject><subject>Liver cancer</subject><subject>Liver Neoplasms, Experimental - diagnostic imaging</subject><subject>Liver Neoplasms, Experimental - metabolism</subject><subject>Liver Neoplasms, Experimental - pathology</subject><subject>Magnetic Resonance Imaging</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Molecular Probes</subject><subject>multidisciplinary</subject><subject>Organometallic Compounds</subject><subject>Performance assessment</subject><subject>Rabbits</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Tumors</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc1u1DAUhSMEolXpC7BAltiwCcTXv9kgVRW0SJXYwNpyPDczrhJ7sB3UPgmvi8MMpbDAG1v2d86916dpXtLuLe2Yfpc5Fb1uO-hapSTwVj9pTqHjogUG8PTR-aQ5z_m2q0tAz2n_vDlhDLiiWpw2Py5yxpxnDIXEkZQdkh3ubfGOlGWOieBdSdbhNC2TTWS2Jfk7smQftgQnm4sPbd6j82NVzHFCd-S2AVeThDkGGxwSX-9WlQ_Ehmq7x-TXsnYiyQ6DL8StXNXGDU4vmmejnTKeH_ez5uvHD18ur9ubz1efLi9uWscVL-3IqYOhB225GqQdmewVBcW4k3Jw6MAJKrh2g0QYnAIhB77Rmm4c70bJFDtr3h9898sw48bVhpKdzL72ZtO9idabv1-C35lt_G6U7IVmUA3eHA1S_LZgLmb2ef0vGzAu2QCXgjMBlFf09T_obVxSqONVSjGgXc9WCg6USzHnhONDM7Qza_TmEL2p0Ztf0RtdRa8ej_Eg-R10BdgByPUpbDH9qf0f259QJ73S</recordid><startdate>20201127</startdate><enddate>20201127</enddate><creator>Keller, Sarah</creator><creator>Borde, Tabea</creator><creator>Brangsch, Julia</creator><creator>Reimann, Carolin</creator><creator>Kader, Avan</creator><creator>Schulze, Daniel</creator><creator>Buchholz, Rebecca</creator><creator>Kaufmann, Jan O.</creator><creator>Karst, Uwe</creator><creator>Schellenberger, Eyk</creator><creator>Hamm, Bernd</creator><creator>Makowski, Marcus R.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20201127</creationdate><title>Assessment of the hepatic tumor extracellular matrix using elastin-specific molecular magnetic resonance imaging in an experimental rabbit cancer model</title><author>Keller, Sarah ; Borde, Tabea ; Brangsch, Julia ; Reimann, Carolin ; Kader, Avan ; Schulze, Daniel ; Buchholz, Rebecca ; Kaufmann, Jan O. ; Karst, Uwe ; Schellenberger, Eyk ; Hamm, Bernd ; Makowski, Marcus R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-f41c2b928a47b6af369712734c66bcec2c51548cb6e2bc7256b4d881dc40f6373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>692/700/1421/1628</topic><topic>692/700/1421/2160</topic><topic>Animals</topic><topic>Cell Line, Tumor</topic><topic>Contrast Media</topic><topic>Elastin</topic><topic>Elastin - metabolism</topic><topic>Extracellular matrix</topic><topic>Extracellular Matrix - metabolism</topic><topic>Extracellular Matrix - pathology</topic><topic>Female</topic><topic>Fibers</topic><topic>Gadolinium</topic><topic>Histopathology</topic><topic>Humanities and Social Sciences</topic><topic>Liver</topic><topic>Liver cancer</topic><topic>Liver Neoplasms, Experimental - diagnostic imaging</topic><topic>Liver Neoplasms, Experimental - metabolism</topic><topic>Liver Neoplasms, Experimental - pathology</topic><topic>Magnetic Resonance Imaging</topic><topic>Mass spectrometry</topic><topic>Mass spectroscopy</topic><topic>Molecular Probes</topic><topic>multidisciplinary</topic><topic>Organometallic Compounds</topic><topic>Performance assessment</topic><topic>Rabbits</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Keller, Sarah</creatorcontrib><creatorcontrib>Borde, Tabea</creatorcontrib><creatorcontrib>Brangsch, Julia</creatorcontrib><creatorcontrib>Reimann, Carolin</creatorcontrib><creatorcontrib>Kader, Avan</creatorcontrib><creatorcontrib>Schulze, Daniel</creatorcontrib><creatorcontrib>Buchholz, Rebecca</creatorcontrib><creatorcontrib>Kaufmann, Jan O.</creatorcontrib><creatorcontrib>Karst, Uwe</creatorcontrib><creatorcontrib>Schellenberger, Eyk</creatorcontrib><creatorcontrib>Hamm, Bernd</creatorcontrib><creatorcontrib>Makowski, Marcus R.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database (ProQuest)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Keller, Sarah</au><au>Borde, Tabea</au><au>Brangsch, Julia</au><au>Reimann, Carolin</au><au>Kader, Avan</au><au>Schulze, Daniel</au><au>Buchholz, Rebecca</au><au>Kaufmann, Jan O.</au><au>Karst, Uwe</au><au>Schellenberger, Eyk</au><au>Hamm, Bernd</au><au>Makowski, Marcus R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of the hepatic tumor extracellular matrix using elastin-specific molecular magnetic resonance imaging in an experimental rabbit cancer model</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-11-27</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>20785</spage><epage>20785</epage><pages>20785-20785</pages><artnum>20785</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>To investigate the imaging performance of an elastin-specific molecular magnetic resonance imaging (MRI) probe with respect to the extracellular matrix (ECM) in an experimental hepatic cancer model. Twelve rabbits with hepatic VX2 tumors were examined using 3 T MRI 14, 21, and 28 days after tumor implantation for two subsequent days (gadobutrol, day 1; elastin-specific probe, day 2). The relative enhancement (RE) of segmented tumor regions (central and margin) and the peritumoral matrix was calculated using pre-contrast and delayed-phase T1w sequences. MRI measurements were correlated to histopathology and element-specific and spatially resolved mass spectrometry (MS). Mixed-model analysis was performed to assess the performance of the elastin-specific probe. In comparison to gadobutrol, the elastin probe showed significantly stronger RE, which was pronounced in the tumor margin (day 14–28:
P
≤ 0.007). In addition, the elastin probe was superior in discriminating between tumor regions (χ
2
(4) = 65.87;
P
< 0.001). MRI-based measurements of the elastin probe significantly correlated with the ex vivo elastinstain (R = .84;
P
<0 .001) and absolute gadolinium concentrations (ICP-MS: R = .73,
P
<0 .01). LA-ICP-MS imaging confirmed the colocalization of the elastin-specific probe with elastic fibers. Elastin-specific molecular MRI is superior to non-specific gadolinium-based contrast agents in imaging the ECM of hepatic tumors and the peritumoral tissue.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33247185</pmid><doi>10.1038/s41598-020-77624-8</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2045-2322 |
| ispartof | Scientific reports, 2020-11, Vol.10 (1), p.20785-20785, Article 20785 |
| issn | 2045-2322 2045-2322 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7695832 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Springer Nature OA Free Journals; Nature Free; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | 692/700/1421/1628 692/700/1421/2160 Animals Cell Line, Tumor Contrast Media Elastin Elastin - metabolism Extracellular matrix Extracellular Matrix - metabolism Extracellular Matrix - pathology Female Fibers Gadolinium Histopathology Humanities and Social Sciences Liver Liver cancer Liver Neoplasms, Experimental - diagnostic imaging Liver Neoplasms, Experimental - metabolism Liver Neoplasms, Experimental - pathology Magnetic Resonance Imaging Mass spectrometry Mass spectroscopy Molecular Probes multidisciplinary Organometallic Compounds Performance assessment Rabbits Science Science (multidisciplinary) Tumors |
| title | Assessment of the hepatic tumor extracellular matrix using elastin-specific molecular magnetic resonance imaging in an experimental rabbit cancer model |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T15%3A33%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Assessment%20of%20the%20hepatic%20tumor%20extracellular%20matrix%20using%20elastin-specific%20molecular%20magnetic%20resonance%20imaging%20in%20an%20experimental%20rabbit%20cancer%20model&rft.jtitle=Scientific%20reports&rft.au=Keller,%20Sarah&rft.date=2020-11-27&rft.volume=10&rft.issue=1&rft.spage=20785&rft.epage=20785&rft.pages=20785-20785&rft.artnum=20785&rft.issn=2045-2322&rft.eissn=2045-2322&rft_id=info:doi/10.1038/s41598-020-77624-8&rft_dat=%3Cproquest_pubme%3E2465435214%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2473210934&rft_id=info:pmid/33247185&rfr_iscdi=true |