Protective Effect of miR-204 on Doxorubicin-Induced Cardiomyocyte Injury via HMGB1

The toxicity of doxorubicin (DOX) limits its clinical application. Nevertheless, at present, there is no effective drug to prevent DOX-induced cardiac injury. miR-204 is a newly discovered miRNA with many protective effects on cardiovascular diseases. However, little research has been done on the ef...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2020, Vol.2020 (2020), p.1-16
Hauptverfasser:	Yao, Rui, Zhao, Luosha, Liu, Guanghui, Du, Youyou
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Apoptosis Apoptosis - drug effects Apoptosis - genetics Autophagy Binding sites Cardiomyocytes Cardiomyopathy Cardiotoxins - adverse effects Cardiotoxins - pharmacology Cloning Dehydrogenases Doxorubicin - adverse effects Doxorubicin - pharmacology Gene expression HMGB1 Protein - genetics HMGB1 Protein - metabolism Inflammation - chemically induced Inflammation - genetics Inflammation - metabolism Inflammation - prevention & control Kinases Laboratory animals Male Mice MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Proteins Software Ultrasonic imaging Variance analysis
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