Impairment of motor coordination and interneuron migration in perinatal exposure to glufosinate-ammonium
Glufosinate-ammonium (GLA) is a broad-spectrum herbicide for agricultural weed control and crop desiccation. Due to many GLA-resistant crops being developed to effectively control weeds and increase harvest yields, herbicide usage and the residual GLA in food has increased significantly. Though peri...
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| Veröffentlicht in: | Scientific reports 2020-11, Vol.10 (1), p.20647, Article 20647 |
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| description | Glufosinate-ammonium (GLA) is a broad-spectrum herbicide for agricultural weed control and crop desiccation. Due to many GLA-resistant crops being developed to effectively control weeds and increase harvest yields, herbicide usage and the residual GLA in food has increased significantly. Though perinatal exposure by the residual GLA in food might affect brain development, the developmental neurotoxicity of GLA is still unclear. Therefore, this study aimed to investigate the effects of perinatal exposure to GLA on cortical development. The analysis revealed that perinatal GLA exposure altered behavioral changes in offspring, especially motor functional behavior. Moreover, perinatal GLA exposure affected cortical development, particularly by disrupting interneuron migration. These results provide new evidence that early life exposure to GLA alters cortical development. |
| doi_str_mv | 10.1038/s41598-020-76869-7 |
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These results provide new evidence that early life exposure to GLA alters cortical development.</description><subject>631/136</subject><subject>631/136/368/2430</subject><subject>Agrochemicals</subject><subject>Aminobutyrates - adverse effects</subject><subject>Ammonium</subject><subject>Animals</subject><subject>Cell Movement - drug effects</subject><subject>Cells, Cultured</subject><subject>Crops, Agricultural - drug effects</subject><subject>Desiccation</subject><subject>Female</subject><subject>Glufosinate</subject><subject>Herbicides</subject><subject>Herbicides - adverse effects</subject><subject>Humanities and Social Sciences</subject><subject>Interneurons - drug effects</subject><subject>Male</subject><subject>Motor Cortex - drug effects</subject><subject>multidisciplinary</subject><subject>Neurotoxicity</subject><subject>Neurotoxicity Syndromes - etiology</subject><subject>Offspring</subject><subject>Perinatal exposure</subject><subject>Rats, Sprague-Dawley</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Weed control</subject><subject>Weeds</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kUtPxCAUhYnRqBn9Ay4Miesqr5ayMTHGxyQmbnRNmAIzmAEqtEb_vYz1uZEN3Jxzz73kA-AIo1OMaHuWGa5FWyGCKt60jaj4FtgniNUVoYRs_3rvgcOcn1A5NREMi12wRylhDGGyD1Zz3yuXvAkDjBb6OMQEuxiTdkENLgaogoYuDCYFM6ZSe7dMk-IC7E3a-NQamtc-5jEZOES4XI825o1gKuV9DG70B2DHqnU2h5_3DDxeXz1c3lZ39zfzy4u7qqsJHyrbGctxR5pWMIaJ4AvLNWsMYZYJ1ClqzaJu27Y2nCmMasqJ1qKhC221phjTGTifcvtx4Y3uyseSWss-Oa_Sm4zKyb9KcCu5jC-SNwILgUrAyWdAis-jyYN8imMKZWdJGKek4Yiy4iKTq0sx52Ts9wSM5AaQnADJAkh-AJK8NB3_3u275QtHMdDJkIsUlib9zP4n9h0PUp8f</recordid><startdate>20201126</startdate><enddate>20201126</enddate><creator>Kim, Kyung-Tai</creator><creator>Kwak, Ye-Jung</creator><creator>Han, Su-Cheol</creator><creator>Hwang, Jeong Ho</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>5PM</scope></search><sort><creationdate>20201126</creationdate><title>Impairment of motor coordination and interneuron migration in perinatal exposure to glufosinate-ammonium</title><author>Kim, Kyung-Tai ; Kwak, Ye-Jung ; Han, Su-Cheol ; Hwang, Jeong Ho</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c527t-fcef71c2689441297bf7d46e24f490ca3feb58885e74a105372dd963bdfdd3113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>631/136</topic><topic>631/136/368/2430</topic><topic>Agrochemicals</topic><topic>Aminobutyrates - adverse effects</topic><topic>Ammonium</topic><topic>Animals</topic><topic>Cell Movement - drug effects</topic><topic>Cells, Cultured</topic><topic>Crops, Agricultural - drug effects</topic><topic>Desiccation</topic><topic>Female</topic><topic>Glufosinate</topic><topic>Herbicides</topic><topic>Herbicides - adverse effects</topic><topic>Humanities and Social Sciences</topic><topic>Interneurons - drug effects</topic><topic>Male</topic><topic>Motor Cortex - drug effects</topic><topic>multidisciplinary</topic><topic>Neurotoxicity</topic><topic>Neurotoxicity Syndromes - etiology</topic><topic>Offspring</topic><topic>Perinatal exposure</topic><topic>Rats, Sprague-Dawley</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Weed control</topic><topic>Weeds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Kyung-Tai</creatorcontrib><creatorcontrib>Kwak, Ye-Jung</creatorcontrib><creatorcontrib>Han, Su-Cheol</creatorcontrib><creatorcontrib>Hwang, Jeong Ho</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Science Journals</collection><collection>ProQuest Biological Science Journals</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Kyung-Tai</au><au>Kwak, Ye-Jung</au><au>Han, Su-Cheol</au><au>Hwang, Jeong Ho</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impairment of motor coordination and interneuron migration in perinatal exposure to glufosinate-ammonium</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-11-26</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>20647</spage><pages>20647-</pages><artnum>20647</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Glufosinate-ammonium (GLA) is a broad-spectrum herbicide for agricultural weed control and crop desiccation. Due to many GLA-resistant crops being developed to effectively control weeds and increase harvest yields, herbicide usage and the residual GLA in food has increased significantly. Though perinatal exposure by the residual GLA in food might affect brain development, the developmental neurotoxicity of GLA is still unclear. Therefore, this study aimed to investigate the effects of perinatal exposure to GLA on cortical development. The analysis revealed that perinatal GLA exposure altered behavioral changes in offspring, especially motor functional behavior. Moreover, perinatal GLA exposure affected cortical development, particularly by disrupting interneuron migration. These results provide new evidence that early life exposure to GLA alters cortical development.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33244012</pmid><doi>10.1038/s41598-020-76869-7</doi><oa>free_for_read</oa></addata></record> |
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| subjects | 631/136 631/136/368/2430 Agrochemicals Aminobutyrates - adverse effects Ammonium Animals Cell Movement - drug effects Cells, Cultured Crops, Agricultural - drug effects Desiccation Female Glufosinate Herbicides Herbicides - adverse effects Humanities and Social Sciences Interneurons - drug effects Male Motor Cortex - drug effects multidisciplinary Neurotoxicity Neurotoxicity Syndromes - etiology Offspring Perinatal exposure Rats, Sprague-Dawley Science Science (multidisciplinary) Weed control Weeds |
| title | Impairment of motor coordination and interneuron migration in perinatal exposure to glufosinate-ammonium |
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