Liquid biopsies and cancer omics
The development of the sequencing technologies allowed the generation of huge amounts of molecular data from a single cancer specimen, allowing the clinical oncology to enter the era of the precision medicine. This massive amount of data is highlighting new details on cancer pathogenesis but still r...
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| Veröffentlicht in: | Cell death discovery 2020-11, Vol.6 (1), p.131-131, Article 131 |
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| creator | Amelio, Ivano Bertolo, Riccardo Bove, Pierluigi Buonomo, Oreste Claudio Candi, Eleonora Chiocchi, Marcello Cipriani, Chiara Di Daniele, Nicola Ganini, Carlo Juhl, Hartmut Mauriello, Alessandro Marani, Carla Marshall, John Montanaro, Manuela Palmieri, Giampiero Piacentini, Mauro Sica, Giuseppe Tesauro, Manfredi Rovella, Valentina Tisone, Giuseppe Shi, Yufang Wang, Ying Melino, Gerry |
| description | The development of the sequencing technologies allowed the generation of huge amounts of molecular data from a single cancer specimen, allowing the clinical oncology to enter the era of the precision medicine. This massive amount of data is highlighting new details on cancer pathogenesis but still relies on tissue biopsies, which are unable to capture the dynamic nature of cancer through its evolution. This assumption led to the exploration of non-tissue sources of tumoral material opening the field of liquid biopsies. Blood, together with body fluids such as urines, or stool, from cancer patients, are analyzed applying the techniques used for the generation of omics data. With blood, this approach would allow to take into account tumor heterogeneity (since the circulating components such as CTCs, ctDNA, or ECVs derive from each cancer clone) in a time dependent manner, resulting in a somehow “real-time” understanding of cancer evolution. Liquid biopsies are beginning nowdays to be applied in many cancer contexts and are at the basis of many clinical trials in oncology. |
| doi_str_mv | 10.1038/s41420-020-00373-0 |
| format | Article |
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| ispartof | Cell death discovery, 2020-11, Vol.6 (1), p.131-131, Article 131 |
| issn | 2058-7716 2058-7716 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7691330 |
| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; Springer Nature OA Free Journals; Nature Free; PubMed Central |
| subjects | 631/67/69 692/53/2422 Apoptosis Biochemistry Biomedical and Life Sciences Biopsy Body fluids Cancer Cell Biology Cell Cycle Analysis Clinical trials Life Sciences Oncology Precision medicine Review Review Article Stem Cells |
| title | Liquid biopsies and cancer omics |
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