β-Arrestin–Biased AT1 Agonist TRV027 Causes a Neonatal-Specific Sustained Positive Inotropic Effect Without Increasing Heart Rate

[Display omitted] •β-arrestin–biased AT1 agonist TRV027 causes a neonatal-specific, long-acting positive inotropic effect with minimum effect on heart rate, oxygen consumption, reactive oxygen species production, and aldosterone secretion.•Although TRV027 stimulates adrenaline secretion, it does not...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	JACC. Basic to translational science 2020-11, Vol.5 (11), p.1057-1069
Hauptverfasser:	Kashihara, Toshihide, Kawagishi, Hiroyuki, Nakada, Tsutomu, Numaga-Tomita, Takuro, Kadota, Shin, Wolf, Elena E., Du, Cheng-Kun, Shiba, Yuji, Morimoto, Sachio, Yamada, Mitsuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	congenital dilated cardiomyopathy human induced pluripotent stem cell-derived cardiac myocytes inotropic vasodilator neonate pediatric heart failure Preclinical Research TRV027 β-arrestin–biased AT1 angiotensin receptor agonist
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!