Micronutrient supplementation of lactating Guatemalan women acutely increases infants’ intake of riboflavin, thiamin, pyridoxal, and cobalamin, but not niacin, in a randomized crossover trial
Maternal supplementation during lactation could increase milk B-vitamin concentrations, but little is known about the kinetics of milk vitamin responses. We compared acute effects of maternal lipid-based nutrient supplement (LNS) consumption (n = 22 nutrients, 175%–212% of the RDA intake for the nut...
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| Veröffentlicht in: | The American journal of clinical nutrition 2020-09, Vol.112 (3), p.669-682 |
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| creator | Donohue, Juliana A Solomons, Noel W Hampel, Daniela Shahab-Ferdows, Setareh Orozco, Mónica N Allen, Lindsay H |
| description | Maternal supplementation during lactation could increase milk B-vitamin concentrations, but little is known about the kinetics of milk vitamin responses.
We compared acute effects of maternal lipid-based nutrient supplement (LNS) consumption (n = 22 nutrients, 175%–212% of the RDA intake for the nutrients examined), as a single dose or at spaced intervals during 8 h, on milk concentrations and infant intake from milk of B-vitamins.
This randomized crossover trial in Quetzaltenango, Guatemala included 26 mother–infant dyads 4–6 mo postpartum who were randomly assigned to receive 3 treatments in a random order: bolus 30-g dose of LNS (Bolus); 3 × 10-g doses of LNS (Divided); and no LNS (Control), with control meals. Mothers attended three 8-h visits during which infant milk consumption was measured and milk samples were collected at every feed. Infant intake was assessed as ∑i = 1n(milk volumefeed n× nutrient concentrationfeed n) over 8 h.
Maternal supplementation with the Bolus or Divided dose increased least-squares mean (95% CI) milk and infant intakes of riboflavin [milk: Bolus: 154.4 (138.2, 172.5) μg · min−1 · mL−1; Control: 84.5 (75.8, 94.3) μg · min−1 · mL−1; infant: Bolus: 64.5 (56.1, 74.3) μg; Control: 34.5 (30.0, 39.6) μg], thiamin [milk: Bolus: 10.9 (10.1, 11.7) μg · min−1 · mL−1; Control: 7.7 (7.2, 8.3) μg · min−1 · mL−1; infant: Bolus: 5.1 (4.4, 6.0) μg; Control: 3.4 (2.9, 4.0) μg], and pyridoxal [milk: Bolus: 90.5 (82.8, 98.9) μg · min−1 · mL−1; Control: 60.8 (55.8, 66.3) μg · min−1 · mL−1; infant: Bolus: 39.4 (33.5, 46.4) μg; Control: 25.0 (21.4, 29.2) μg] (all P < 0.001). Only the Bolus dose increased cobalamin in milk [Bolus: 0.054 (0.047, 0.061) μg · min−1 · mL−1; Control: 0.041 (0.035, 0.048) μg · min−1 · mL−1, P = 0.039] and infant cobalamin intake [Bolus: 0.023 (0.020, 0.027) μg; Control: 0.015 (0.013, 0.018) μg, P = 0.001] compared with Control. Niacin was unaffected.
Maternal supplementation with LNS as a Bolus or Divided dose was similarly effective at increasing milk riboflavin, thiamin, and pyridoxal and infant intakes, whereas only the Bolus dose increased cobalamin. Niacin was unaffected in 8 h. This trial was registered at clinicaltrials.gov as NCT02464111. |
| doi_str_mv | 10.1093/ajcn/nqaa147 |
| format | Article |
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We compared acute effects of maternal lipid-based nutrient supplement (LNS) consumption (n = 22 nutrients, 175%–212% of the RDA intake for the nutrients examined), as a single dose or at spaced intervals during 8 h, on milk concentrations and infant intake from milk of B-vitamins.
This randomized crossover trial in Quetzaltenango, Guatemala included 26 mother–infant dyads 4–6 mo postpartum who were randomly assigned to receive 3 treatments in a random order: bolus 30-g dose of LNS (Bolus); 3 × 10-g doses of LNS (Divided); and no LNS (Control), with control meals. Mothers attended three 8-h visits during which infant milk consumption was measured and milk samples were collected at every feed. Infant intake was assessed as ∑i = 1n(milk volumefeed n× nutrient concentrationfeed n) over 8 h.
Maternal supplementation with the Bolus or Divided dose increased least-squares mean (95% CI) milk and infant intakes of riboflavin [milk: Bolus: 154.4 (138.2, 172.5) μg · min−1 · mL−1; Control: 84.5 (75.8, 94.3) μg · min−1 · mL−1; infant: Bolus: 64.5 (56.1, 74.3) μg; Control: 34.5 (30.0, 39.6) μg], thiamin [milk: Bolus: 10.9 (10.1, 11.7) μg · min−1 · mL−1; Control: 7.7 (7.2, 8.3) μg · min−1 · mL−1; infant: Bolus: 5.1 (4.4, 6.0) μg; Control: 3.4 (2.9, 4.0) μg], and pyridoxal [milk: Bolus: 90.5 (82.8, 98.9) μg · min−1 · mL−1; Control: 60.8 (55.8, 66.3) μg · min−1 · mL−1; infant: Bolus: 39.4 (33.5, 46.4) μg; Control: 25.0 (21.4, 29.2) μg] (all P < 0.001). Only the Bolus dose increased cobalamin in milk [Bolus: 0.054 (0.047, 0.061) μg · min−1 · mL−1; Control: 0.041 (0.035, 0.048) μg · min−1 · mL−1, P = 0.039] and infant cobalamin intake [Bolus: 0.023 (0.020, 0.027) μg; Control: 0.015 (0.013, 0.018) μg, P = 0.001] compared with Control. Niacin was unaffected.
Maternal supplementation with LNS as a Bolus or Divided dose was similarly effective at increasing milk riboflavin, thiamin, and pyridoxal and infant intakes, whereas only the Bolus dose increased cobalamin. Niacin was unaffected in 8 h. This trial was registered at clinicaltrials.gov as NCT02464111.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.1093/ajcn/nqaa147</identifier><identifier>PMID: 32649760</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject><![CDATA[Acute effects ; Adult ; Area Under Curve ; B vitamins ; Breast Feeding ; Cross-Over Studies ; Dietary Supplements ; Editor's Choice ; Female ; Guatemala ; human milk ; Humans ; Infant ; Infant formulas ; Infants ; Lactation ; lipid-based nutrient supplement ; Lipids ; maternal ; Meals ; Micronutrients - administration & dosage ; Micronutrients - blood ; Micronutrients - chemistry ; Milk ; Milk, Human - chemistry ; Niacin - administration & dosage ; Niacin - blood ; Niacin - pharmacokinetics ; Nutrient concentrations ; Nutrients ; Original Research Communications ; Postpartum ; Pyridoxal - administration & dosage ; Pyridoxal - blood ; Pyridoxal - pharmacokinetics ; Riboflavin ; Riboflavin - administration & dosage ; Riboflavin - blood ; Riboflavin - pharmacokinetics ; Supplements ; Thiamine ; Thiamine - administration & dosage ; Thiamine - blood ; Thiamine - pharmacokinetics ; Vitamin B ; Vitamin B 12 - administration & dosage ; Vitamin B 12 - blood ; Vitamin B 12 - pharmacokinetics ; Vitamin B12 ; Vitamins ; Vitamins - administration & dosage ; Vitamins - blood ; Vitamins - pharmacokinetics ; Young Adult]]></subject><ispartof>The American journal of clinical nutrition, 2020-09, Vol.112 (3), p.669-682</ispartof><rights>2020 American Society for Nutrition.</rights><rights>Published by Oxford University Press on behalf of the American Society for Nutrition 2020. 2020</rights><rights>Published by Oxford University Press on behalf of the American Society for Nutrition 2020.</rights><rights>Copyright American Society for Clinical Nutrition, Inc. Sep 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-1f9dad52678a591e07b13e68c4e05128fdebfd9457b3ee98f84b1f288c0a1f513</citedby><cites>FETCH-LOGICAL-c491t-1f9dad52678a591e07b13e68c4e05128fdebfd9457b3ee98f84b1f288c0a1f513</cites><orcidid>0000-0003-0288-7680 ; 0000-0001-6314-7526 ; 0000-0002-1013-2280 ; 0000-0002-5058-4935 ; 0000-0003-0238-1348 ; 0000-0002-8729-5213</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32649760$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Donohue, Juliana A</creatorcontrib><creatorcontrib>Solomons, Noel W</creatorcontrib><creatorcontrib>Hampel, Daniela</creatorcontrib><creatorcontrib>Shahab-Ferdows, Setareh</creatorcontrib><creatorcontrib>Orozco, Mónica N</creatorcontrib><creatorcontrib>Allen, Lindsay H</creatorcontrib><title>Micronutrient supplementation of lactating Guatemalan women acutely increases infants’ intake of riboflavin, thiamin, pyridoxal, and cobalamin, but not niacin, in a randomized crossover trial</title><title>The American journal of clinical nutrition</title><addtitle>Am J Clin Nutr</addtitle><description>Maternal supplementation during lactation could increase milk B-vitamin concentrations, but little is known about the kinetics of milk vitamin responses.
We compared acute effects of maternal lipid-based nutrient supplement (LNS) consumption (n = 22 nutrients, 175%–212% of the RDA intake for the nutrients examined), as a single dose or at spaced intervals during 8 h, on milk concentrations and infant intake from milk of B-vitamins.
This randomized crossover trial in Quetzaltenango, Guatemala included 26 mother–infant dyads 4–6 mo postpartum who were randomly assigned to receive 3 treatments in a random order: bolus 30-g dose of LNS (Bolus); 3 × 10-g doses of LNS (Divided); and no LNS (Control), with control meals. Mothers attended three 8-h visits during which infant milk consumption was measured and milk samples were collected at every feed. Infant intake was assessed as ∑i = 1n(milk volumefeed n× nutrient concentrationfeed n) over 8 h.
Maternal supplementation with the Bolus or Divided dose increased least-squares mean (95% CI) milk and infant intakes of riboflavin [milk: Bolus: 154.4 (138.2, 172.5) μg · min−1 · mL−1; Control: 84.5 (75.8, 94.3) μg · min−1 · mL−1; infant: Bolus: 64.5 (56.1, 74.3) μg; Control: 34.5 (30.0, 39.6) μg], thiamin [milk: Bolus: 10.9 (10.1, 11.7) μg · min−1 · mL−1; Control: 7.7 (7.2, 8.3) μg · min−1 · mL−1; infant: Bolus: 5.1 (4.4, 6.0) μg; Control: 3.4 (2.9, 4.0) μg], and pyridoxal [milk: Bolus: 90.5 (82.8, 98.9) μg · min−1 · mL−1; Control: 60.8 (55.8, 66.3) μg · min−1 · mL−1; infant: Bolus: 39.4 (33.5, 46.4) μg; Control: 25.0 (21.4, 29.2) μg] (all P < 0.001). Only the Bolus dose increased cobalamin in milk [Bolus: 0.054 (0.047, 0.061) μg · min−1 · mL−1; Control: 0.041 (0.035, 0.048) μg · min−1 · mL−1, P = 0.039] and infant cobalamin intake [Bolus: 0.023 (0.020, 0.027) μg; Control: 0.015 (0.013, 0.018) μg, P = 0.001] compared with Control. Niacin was unaffected.
Maternal supplementation with LNS as a Bolus or Divided dose was similarly effective at increasing milk riboflavin, thiamin, and pyridoxal and infant intakes, whereas only the Bolus dose increased cobalamin. Niacin was unaffected in 8 h. This trial was registered at clinicaltrials.gov as NCT02464111.</description><subject>Acute effects</subject><subject>Adult</subject><subject>Area Under Curve</subject><subject>B vitamins</subject><subject>Breast Feeding</subject><subject>Cross-Over Studies</subject><subject>Dietary Supplements</subject><subject>Editor's Choice</subject><subject>Female</subject><subject>Guatemala</subject><subject>human milk</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant formulas</subject><subject>Infants</subject><subject>Lactation</subject><subject>lipid-based nutrient supplement</subject><subject>Lipids</subject><subject>maternal</subject><subject>Meals</subject><subject>Micronutrients - administration & dosage</subject><subject>Micronutrients - blood</subject><subject>Micronutrients - chemistry</subject><subject>Milk</subject><subject>Milk, Human - chemistry</subject><subject>Niacin - administration & dosage</subject><subject>Niacin - blood</subject><subject>Niacin - pharmacokinetics</subject><subject>Nutrient concentrations</subject><subject>Nutrients</subject><subject>Original Research Communications</subject><subject>Postpartum</subject><subject>Pyridoxal - administration & dosage</subject><subject>Pyridoxal - blood</subject><subject>Pyridoxal - pharmacokinetics</subject><subject>Riboflavin</subject><subject>Riboflavin - administration & dosage</subject><subject>Riboflavin - blood</subject><subject>Riboflavin - pharmacokinetics</subject><subject>Supplements</subject><subject>Thiamine</subject><subject>Thiamine - administration & dosage</subject><subject>Thiamine - blood</subject><subject>Thiamine - pharmacokinetics</subject><subject>Vitamin B</subject><subject>Vitamin B 12 - administration & dosage</subject><subject>Vitamin B 12 - blood</subject><subject>Vitamin B 12 - pharmacokinetics</subject><subject>Vitamin B12</subject><subject>Vitamins</subject><subject>Vitamins - administration & dosage</subject><subject>Vitamins - blood</subject><subject>Vitamins - pharmacokinetics</subject><subject>Young Adult</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks9u1DAQxiMEokvhxhlZ4sBlQ-3E-eMLEqpoQSriAmdr4oxbL4md2s7Ccupr8Di8Ck-C010qkJA4WJ7R_PzN2J-z7CmjLxkV5QlslD2x1wCMN_eyFRNlm5cFbe5nK0ppkQtWV0fZoxA2lLKCt_XD7Kgsai6amq6yH--N8s7O0Ru0kYR5mgYcUwjROEucJgOoJbGX5HyGiCMMYMkXlxgCao447IixyiMEDCnSYGP4efM9hRE-46LgTef0AFtj1yReGRiXYNp507uvMKwJ2J4o1yXh20o3R2JdWgbUkpvUiPgEudF8w4R6F4LboidpaBgeZw80DAGfHPbj7NPZm4-nb_OLD-fvTl9f5IoLFnOmRQ99VdRNC5VgSJuOlVi3iiOtWNHqHjvdC141XYkoWt3yjumibRUFpitWHmev9rrT3I3Yq_RGHgY5eTOC30kHRv5dseZKXrqtbGpBm5ongecHAe-uZwxRbtzsbZpZFpzzumEtpYla76nba3rUdx0YlYvhcjFcHgxP-LM_p7qDfzucgBd7wM3T_6TqPYnpFbcGvQwqfQqFvfGoouyd-ffBX3aR0KE</recordid><startdate>20200901</startdate><enddate>20200901</enddate><creator>Donohue, Juliana A</creator><creator>Solomons, Noel W</creator><creator>Hampel, Daniela</creator><creator>Shahab-Ferdows, Setareh</creator><creator>Orozco, Mónica N</creator><creator>Allen, Lindsay H</creator><general>Elsevier Inc</general><general>Oxford University Press</general><general>American Society for Clinical Nutrition, Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T7</scope><scope>7TS</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0288-7680</orcidid><orcidid>https://orcid.org/0000-0001-6314-7526</orcidid><orcidid>https://orcid.org/0000-0002-1013-2280</orcidid><orcidid>https://orcid.org/0000-0002-5058-4935</orcidid><orcidid>https://orcid.org/0000-0003-0238-1348</orcidid><orcidid>https://orcid.org/0000-0002-8729-5213</orcidid></search><sort><creationdate>20200901</creationdate><title>Micronutrient supplementation of lactating Guatemalan women acutely increases infants’ intake of riboflavin, thiamin, pyridoxal, and cobalamin, but not niacin, in a randomized crossover trial</title><author>Donohue, Juliana A ; Solomons, Noel W ; Hampel, Daniela ; Shahab-Ferdows, Setareh ; Orozco, Mónica N ; Allen, Lindsay H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-1f9dad52678a591e07b13e68c4e05128fdebfd9457b3ee98f84b1f288c0a1f513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acute effects</topic><topic>Adult</topic><topic>Area Under Curve</topic><topic>B vitamins</topic><topic>Breast Feeding</topic><topic>Cross-Over Studies</topic><topic>Dietary Supplements</topic><topic>Editor's Choice</topic><topic>Female</topic><topic>Guatemala</topic><topic>human milk</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant formulas</topic><topic>Infants</topic><topic>Lactation</topic><topic>lipid-based nutrient supplement</topic><topic>Lipids</topic><topic>maternal</topic><topic>Meals</topic><topic>Micronutrients - administration & dosage</topic><topic>Micronutrients - blood</topic><topic>Micronutrients - chemistry</topic><topic>Milk</topic><topic>Milk, Human - chemistry</topic><topic>Niacin - administration & dosage</topic><topic>Niacin - blood</topic><topic>Niacin - pharmacokinetics</topic><topic>Nutrient concentrations</topic><topic>Nutrients</topic><topic>Original Research Communications</topic><topic>Postpartum</topic><topic>Pyridoxal - administration & dosage</topic><topic>Pyridoxal - blood</topic><topic>Pyridoxal - pharmacokinetics</topic><topic>Riboflavin</topic><topic>Riboflavin - administration & dosage</topic><topic>Riboflavin - blood</topic><topic>Riboflavin - pharmacokinetics</topic><topic>Supplements</topic><topic>Thiamine</topic><topic>Thiamine - administration & dosage</topic><topic>Thiamine - blood</topic><topic>Thiamine - pharmacokinetics</topic><topic>Vitamin B</topic><topic>Vitamin B 12 - administration & dosage</topic><topic>Vitamin B 12 - blood</topic><topic>Vitamin B 12 - pharmacokinetics</topic><topic>Vitamin B12</topic><topic>Vitamins</topic><topic>Vitamins - administration & dosage</topic><topic>Vitamins - blood</topic><topic>Vitamins - pharmacokinetics</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Donohue, Juliana A</creatorcontrib><creatorcontrib>Solomons, Noel W</creatorcontrib><creatorcontrib>Hampel, Daniela</creatorcontrib><creatorcontrib>Shahab-Ferdows, Setareh</creatorcontrib><creatorcontrib>Orozco, Mónica N</creatorcontrib><creatorcontrib>Allen, Lindsay H</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Donohue, Juliana A</au><au>Solomons, Noel W</au><au>Hampel, Daniela</au><au>Shahab-Ferdows, Setareh</au><au>Orozco, Mónica N</au><au>Allen, Lindsay H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Micronutrient supplementation of lactating Guatemalan women acutely increases infants’ intake of riboflavin, thiamin, pyridoxal, and cobalamin, but not niacin, in a randomized crossover trial</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>2020-09-01</date><risdate>2020</risdate><volume>112</volume><issue>3</issue><spage>669</spage><epage>682</epage><pages>669-682</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><abstract>Maternal supplementation during lactation could increase milk B-vitamin concentrations, but little is known about the kinetics of milk vitamin responses.
We compared acute effects of maternal lipid-based nutrient supplement (LNS) consumption (n = 22 nutrients, 175%–212% of the RDA intake for the nutrients examined), as a single dose or at spaced intervals during 8 h, on milk concentrations and infant intake from milk of B-vitamins.
This randomized crossover trial in Quetzaltenango, Guatemala included 26 mother–infant dyads 4–6 mo postpartum who were randomly assigned to receive 3 treatments in a random order: bolus 30-g dose of LNS (Bolus); 3 × 10-g doses of LNS (Divided); and no LNS (Control), with control meals. Mothers attended three 8-h visits during which infant milk consumption was measured and milk samples were collected at every feed. Infant intake was assessed as ∑i = 1n(milk volumefeed n× nutrient concentrationfeed n) over 8 h.
Maternal supplementation with the Bolus or Divided dose increased least-squares mean (95% CI) milk and infant intakes of riboflavin [milk: Bolus: 154.4 (138.2, 172.5) μg · min−1 · mL−1; Control: 84.5 (75.8, 94.3) μg · min−1 · mL−1; infant: Bolus: 64.5 (56.1, 74.3) μg; Control: 34.5 (30.0, 39.6) μg], thiamin [milk: Bolus: 10.9 (10.1, 11.7) μg · min−1 · mL−1; Control: 7.7 (7.2, 8.3) μg · min−1 · mL−1; infant: Bolus: 5.1 (4.4, 6.0) μg; Control: 3.4 (2.9, 4.0) μg], and pyridoxal [milk: Bolus: 90.5 (82.8, 98.9) μg · min−1 · mL−1; Control: 60.8 (55.8, 66.3) μg · min−1 · mL−1; infant: Bolus: 39.4 (33.5, 46.4) μg; Control: 25.0 (21.4, 29.2) μg] (all P < 0.001). Only the Bolus dose increased cobalamin in milk [Bolus: 0.054 (0.047, 0.061) μg · min−1 · mL−1; Control: 0.041 (0.035, 0.048) μg · min−1 · mL−1, P = 0.039] and infant cobalamin intake [Bolus: 0.023 (0.020, 0.027) μg; Control: 0.015 (0.013, 0.018) μg, P = 0.001] compared with Control. Niacin was unaffected.
Maternal supplementation with LNS as a Bolus or Divided dose was similarly effective at increasing milk riboflavin, thiamin, and pyridoxal and infant intakes, whereas only the Bolus dose increased cobalamin. Niacin was unaffected in 8 h. This trial was registered at clinicaltrials.gov as NCT02464111.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>32649760</pmid><doi>10.1093/ajcn/nqaa147</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0003-0288-7680</orcidid><orcidid>https://orcid.org/0000-0001-6314-7526</orcidid><orcidid>https://orcid.org/0000-0002-1013-2280</orcidid><orcidid>https://orcid.org/0000-0002-5058-4935</orcidid><orcidid>https://orcid.org/0000-0003-0238-1348</orcidid><orcidid>https://orcid.org/0000-0002-8729-5213</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9165 |
| ispartof | The American journal of clinical nutrition, 2020-09, Vol.112 (3), p.669-682 |
| issn | 0002-9165 1938-3207 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7690764 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Acute effects Adult Area Under Curve B vitamins Breast Feeding Cross-Over Studies Dietary Supplements Editor's Choice Female Guatemala human milk Humans Infant Infant formulas Infants Lactation lipid-based nutrient supplement Lipids maternal Meals Micronutrients - administration & dosage Micronutrients - blood Micronutrients - chemistry Milk Milk, Human - chemistry Niacin - administration & dosage Niacin - blood Niacin - pharmacokinetics Nutrient concentrations Nutrients Original Research Communications Postpartum Pyridoxal - administration & dosage Pyridoxal - blood Pyridoxal - pharmacokinetics Riboflavin Riboflavin - administration & dosage Riboflavin - blood Riboflavin - pharmacokinetics Supplements Thiamine Thiamine - administration & dosage Thiamine - blood Thiamine - pharmacokinetics Vitamin B Vitamin B 12 - administration & dosage Vitamin B 12 - blood Vitamin B 12 - pharmacokinetics Vitamin B12 Vitamins Vitamins - administration & dosage Vitamins - blood Vitamins - pharmacokinetics Young Adult |
| title | Micronutrient supplementation of lactating Guatemalan women acutely increases infants’ intake of riboflavin, thiamin, pyridoxal, and cobalamin, but not niacin, in a randomized crossover trial |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T07%3A30%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Micronutrient%20supplementation%20of%20lactating%20Guatemalan%20women%20acutely%20increases%20infants%E2%80%99%20intake%20of%20riboflavin,%20thiamin,%20pyridoxal,%20and%20cobalamin,%20but%20not%20niacin,%20in%20a%20randomized%20crossover%20trial&rft.jtitle=The%20American%20journal%20of%20clinical%20nutrition&rft.au=Donohue,%20Juliana%20A&rft.date=2020-09-01&rft.volume=112&rft.issue=3&rft.spage=669&rft.epage=682&rft.pages=669-682&rft.issn=0002-9165&rft.eissn=1938-3207&rft_id=info:doi/10.1093/ajcn/nqaa147&rft_dat=%3Cproquest_pubme%3E2444671800%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2444671800&rft_id=info:pmid/32649760&rft_oup_id=10.1093/ajcn/nqaa147&rft_els_id=S0002916522008401&rfr_iscdi=true |