Hippocampal radiotherapy dose constraints for predicting long-term neurocognitive outcomes: mature data from a prospective trial in young patients with brain tumors
Abstract Background Hippocampus is considered to be the seat for neurocognitive functions. Avoidance of hippocampus during radiotherapy to brain may serve to preserve various domains of neurocognition. We aimed to derive radiotherapy dose constraints to hippocampi for preserving neurocognition in yo...
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| Veröffentlicht in: | Neuro-oncology (Charlottesville, Va.) Va.), 2020-11, Vol.22 (11), p.1677-1685 |
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| creator | Goda, Jayant S Dutta, Debnarayan Krishna, Uday Goswami, Savita Kothavade, Vikas Kannan, Sadhna Maitre, Madan Bano, Nazia Gupta, Tejpal Jalali, Rakesh |
| description | Abstract
Background
Hippocampus is considered to be the seat for neurocognitive functions. Avoidance of hippocampus during radiotherapy to brain may serve to preserve various domains of neurocognition. We aimed to derive radiotherapy dose constraints to hippocampi for preserving neurocognition in young patients with brain tumors by measuring various neurocognitive parameters.
Methods
Forty-eight patients with residual/progressive benign or low-grade brain tumors treated with stereotactic conformal radiotherapy (SCRT) to a dose of 54 Gy in 30 fractions underwent prospective neuropsychological assessments at baseline before SCRT and at 6 months and 2, 3, 4, and 5 years. Hippocampi were drawn as per the Radiation Therapy Oncology Group atlas. Longitudinal change in intelligence quotient scores was correlated with hippocampal doses.
Results
Mean volume of bilateral hippocampi was 4.35 cc (range: 2.12–8.41 cc). Craniopharyngioma was the commonest histologic subtype. A drop of >10% in mean full-scale intelligence quotient (FSIQ) scores at 3 and 5 years post SCRT was observed in patients in whom left hippocampus received a mean dose of 30.7 Gy (P = 0.04) and 31 Gy (P = 0.04), respectively. Mean performance quotient (PQ) scores dropped > 10% at 5 years when the left hippocampus received a dose of > 32 Gy (P = 0.03). There was no significant correlation of radiotherapy doses with verbal quotient, or with doses received by the right hippocampus. Multivariate analysis revealed young age ( |
| doi_str_mv | 10.1093/neuonc/noaa076 |
| format | Article |
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Background
Hippocampus is considered to be the seat for neurocognitive functions. Avoidance of hippocampus during radiotherapy to brain may serve to preserve various domains of neurocognition. We aimed to derive radiotherapy dose constraints to hippocampi for preserving neurocognition in young patients with brain tumors by measuring various neurocognitive parameters.
Methods
Forty-eight patients with residual/progressive benign or low-grade brain tumors treated with stereotactic conformal radiotherapy (SCRT) to a dose of 54 Gy in 30 fractions underwent prospective neuropsychological assessments at baseline before SCRT and at 6 months and 2, 3, 4, and 5 years. Hippocampi were drawn as per the Radiation Therapy Oncology Group atlas. Longitudinal change in intelligence quotient scores was correlated with hippocampal doses.
Results
Mean volume of bilateral hippocampi was 4.35 cc (range: 2.12–8.41 cc). Craniopharyngioma was the commonest histologic subtype. A drop of >10% in mean full-scale intelligence quotient (FSIQ) scores at 3 and 5 years post SCRT was observed in patients in whom left hippocampus received a mean dose of 30.7 Gy (P = 0.04) and 31 Gy (P = 0.04), respectively. Mean performance quotient (PQ) scores dropped > 10% at 5 years when the left hippocampus received a dose of > 32 Gy (P = 0.03). There was no significant correlation of radiotherapy doses with verbal quotient, or with doses received by the right hippocampus. Multivariate analysis revealed young age (<13 y) and left hippocampus dose predicted for clinically relevant decline in certain neurocognitive domains.
Conclusions
A mean dose of ≤30 Gy to the left hippocampus as a dose constraint for preserving intelligence quotient is suggested.
Key Points
1. Children and young adults with benign and low-grade gliomas survive long after therapy.
2. Higher dose to the hippocampi may result in long-term neurocognitive impairment.
3. Mean dose of <30 Gy to left hippocampus could be used as a pragmatic dose constraint to prevent long-term neurocognitive decline.</description><identifier>ISSN: 1522-8517</identifier><identifier>EISSN: 1523-5866</identifier><identifier>DOI: 10.1093/neuonc/noaa076</identifier><identifier>PMID: 32227185</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Adolescent ; Brain Neoplasms - radiotherapy ; Child ; Female ; Glioma ; Hippocampus ; Humans ; Male ; Pediatric Neuro-Oncology ; Pituitary Neoplasms ; Prospective Studies ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted ; Treatment Outcome</subject><ispartof>Neuro-oncology (Charlottesville, Va.), 2020-11, Vol.22 (11), p.1677-1685</ispartof><rights>The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2020</rights><rights>The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-d4197e8f8d61a93a86987c9d512a1ccfd79e6c178d93e95c20bfbb395204f0513</citedby><cites>FETCH-LOGICAL-c424t-d4197e8f8d61a93a86987c9d512a1ccfd79e6c178d93e95c20bfbb395204f0513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690355/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690355/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,1584,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32227185$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goda, Jayant S</creatorcontrib><creatorcontrib>Dutta, Debnarayan</creatorcontrib><creatorcontrib>Krishna, Uday</creatorcontrib><creatorcontrib>Goswami, Savita</creatorcontrib><creatorcontrib>Kothavade, Vikas</creatorcontrib><creatorcontrib>Kannan, Sadhna</creatorcontrib><creatorcontrib>Maitre, Madan</creatorcontrib><creatorcontrib>Bano, Nazia</creatorcontrib><creatorcontrib>Gupta, Tejpal</creatorcontrib><creatorcontrib>Jalali, Rakesh</creatorcontrib><title>Hippocampal radiotherapy dose constraints for predicting long-term neurocognitive outcomes: mature data from a prospective trial in young patients with brain tumors</title><title>Neuro-oncology (Charlottesville, Va.)</title><addtitle>Neuro Oncol</addtitle><description>Abstract
Background
Hippocampus is considered to be the seat for neurocognitive functions. Avoidance of hippocampus during radiotherapy to brain may serve to preserve various domains of neurocognition. We aimed to derive radiotherapy dose constraints to hippocampi for preserving neurocognition in young patients with brain tumors by measuring various neurocognitive parameters.
Methods
Forty-eight patients with residual/progressive benign or low-grade brain tumors treated with stereotactic conformal radiotherapy (SCRT) to a dose of 54 Gy in 30 fractions underwent prospective neuropsychological assessments at baseline before SCRT and at 6 months and 2, 3, 4, and 5 years. Hippocampi were drawn as per the Radiation Therapy Oncology Group atlas. Longitudinal change in intelligence quotient scores was correlated with hippocampal doses.
Results
Mean volume of bilateral hippocampi was 4.35 cc (range: 2.12–8.41 cc). Craniopharyngioma was the commonest histologic subtype. A drop of >10% in mean full-scale intelligence quotient (FSIQ) scores at 3 and 5 years post SCRT was observed in patients in whom left hippocampus received a mean dose of 30.7 Gy (P = 0.04) and 31 Gy (P = 0.04), respectively. Mean performance quotient (PQ) scores dropped > 10% at 5 years when the left hippocampus received a dose of > 32 Gy (P = 0.03). There was no significant correlation of radiotherapy doses with verbal quotient, or with doses received by the right hippocampus. Multivariate analysis revealed young age (<13 y) and left hippocampus dose predicted for clinically relevant decline in certain neurocognitive domains.
Conclusions
A mean dose of ≤30 Gy to the left hippocampus as a dose constraint for preserving intelligence quotient is suggested.
Key Points
1. Children and young adults with benign and low-grade gliomas survive long after therapy.
2. Higher dose to the hippocampi may result in long-term neurocognitive impairment.
3. Mean dose of <30 Gy to left hippocampus could be used as a pragmatic dose constraint to prevent long-term neurocognitive decline.</description><subject>Adolescent</subject><subject>Brain Neoplasms - radiotherapy</subject><subject>Child</subject><subject>Female</subject><subject>Glioma</subject><subject>Hippocampus</subject><subject>Humans</subject><subject>Male</subject><subject>Pediatric Neuro-Oncology</subject><subject>Pituitary Neoplasms</subject><subject>Prospective Studies</subject><subject>Radiotherapy Dosage</subject><subject>Radiotherapy Planning, Computer-Assisted</subject><subject>Treatment Outcome</subject><issn>1522-8517</issn><issn>1523-5866</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9r3DAQxUVJaf601x6Drjk4keSVbeVQCKFNCoFe2rMZS_KuylojJDlhv08-aLTZzdKcepqBefN7MzxCvnJ2yZmqr7yd0esrjwCsbT6QEy5FXcmuaY5ee1F1krfH5DSlv4wJLhv-iRzXQoiWd_KEPN-7EFDDFGBNIxiHeWUjhA01mCzV6FOO4HxOdMRIQ7TG6ez8kq7RL6ts40TLDRE1Lr3L7tFSnLPGyaZrOkGeo6UGMtAx4kShADAFq1-FObpi6jzd4FyAAbKzW6Mnl1d02LrSPE8Y02fycYR1sl_29Yz8-fH99-199fDr7uftzUOlF2KRK7PgqrXd2JmGg6qha1TXamUkF8C1Hk2rbKN52xlVWyW1YMM4DLWSgi1GJnl9Rr7tuGEeJmt0uSbCug_RTRA3PYLr30-8W_VLfOzbRrFaygK43AF0eTNFOx52Oeu3efW7vPp9XmXh_F_Hg_wtoCK42AlwDv-DvQCKealu</recordid><startdate>20201126</startdate><enddate>20201126</enddate><creator>Goda, Jayant S</creator><creator>Dutta, Debnarayan</creator><creator>Krishna, Uday</creator><creator>Goswami, Savita</creator><creator>Kothavade, Vikas</creator><creator>Kannan, Sadhna</creator><creator>Maitre, Madan</creator><creator>Bano, Nazia</creator><creator>Gupta, Tejpal</creator><creator>Jalali, Rakesh</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20201126</creationdate><title>Hippocampal radiotherapy dose constraints for predicting long-term neurocognitive outcomes: mature data from a prospective trial in young patients with brain tumors</title><author>Goda, Jayant S ; Dutta, Debnarayan ; Krishna, Uday ; Goswami, Savita ; Kothavade, Vikas ; Kannan, Sadhna ; Maitre, Madan ; Bano, Nazia ; Gupta, Tejpal ; Jalali, Rakesh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-d4197e8f8d61a93a86987c9d512a1ccfd79e6c178d93e95c20bfbb395204f0513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescent</topic><topic>Brain Neoplasms - radiotherapy</topic><topic>Child</topic><topic>Female</topic><topic>Glioma</topic><topic>Hippocampus</topic><topic>Humans</topic><topic>Male</topic><topic>Pediatric Neuro-Oncology</topic><topic>Pituitary Neoplasms</topic><topic>Prospective Studies</topic><topic>Radiotherapy Dosage</topic><topic>Radiotherapy Planning, Computer-Assisted</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goda, Jayant S</creatorcontrib><creatorcontrib>Dutta, Debnarayan</creatorcontrib><creatorcontrib>Krishna, Uday</creatorcontrib><creatorcontrib>Goswami, Savita</creatorcontrib><creatorcontrib>Kothavade, Vikas</creatorcontrib><creatorcontrib>Kannan, Sadhna</creatorcontrib><creatorcontrib>Maitre, Madan</creatorcontrib><creatorcontrib>Bano, Nazia</creatorcontrib><creatorcontrib>Gupta, Tejpal</creatorcontrib><creatorcontrib>Jalali, Rakesh</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neuro-oncology (Charlottesville, Va.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goda, Jayant S</au><au>Dutta, Debnarayan</au><au>Krishna, Uday</au><au>Goswami, Savita</au><au>Kothavade, Vikas</au><au>Kannan, Sadhna</au><au>Maitre, Madan</au><au>Bano, Nazia</au><au>Gupta, Tejpal</au><au>Jalali, Rakesh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hippocampal radiotherapy dose constraints for predicting long-term neurocognitive outcomes: mature data from a prospective trial in young patients with brain tumors</atitle><jtitle>Neuro-oncology (Charlottesville, Va.)</jtitle><addtitle>Neuro Oncol</addtitle><date>2020-11-26</date><risdate>2020</risdate><volume>22</volume><issue>11</issue><spage>1677</spage><epage>1685</epage><pages>1677-1685</pages><issn>1522-8517</issn><eissn>1523-5866</eissn><abstract>Abstract
Background
Hippocampus is considered to be the seat for neurocognitive functions. Avoidance of hippocampus during radiotherapy to brain may serve to preserve various domains of neurocognition. We aimed to derive radiotherapy dose constraints to hippocampi for preserving neurocognition in young patients with brain tumors by measuring various neurocognitive parameters.
Methods
Forty-eight patients with residual/progressive benign or low-grade brain tumors treated with stereotactic conformal radiotherapy (SCRT) to a dose of 54 Gy in 30 fractions underwent prospective neuropsychological assessments at baseline before SCRT and at 6 months and 2, 3, 4, and 5 years. Hippocampi were drawn as per the Radiation Therapy Oncology Group atlas. Longitudinal change in intelligence quotient scores was correlated with hippocampal doses.
Results
Mean volume of bilateral hippocampi was 4.35 cc (range: 2.12–8.41 cc). Craniopharyngioma was the commonest histologic subtype. A drop of >10% in mean full-scale intelligence quotient (FSIQ) scores at 3 and 5 years post SCRT was observed in patients in whom left hippocampus received a mean dose of 30.7 Gy (P = 0.04) and 31 Gy (P = 0.04), respectively. Mean performance quotient (PQ) scores dropped > 10% at 5 years when the left hippocampus received a dose of > 32 Gy (P = 0.03). There was no significant correlation of radiotherapy doses with verbal quotient, or with doses received by the right hippocampus. Multivariate analysis revealed young age (<13 y) and left hippocampus dose predicted for clinically relevant decline in certain neurocognitive domains.
Conclusions
A mean dose of ≤30 Gy to the left hippocampus as a dose constraint for preserving intelligence quotient is suggested.
Key Points
1. Children and young adults with benign and low-grade gliomas survive long after therapy.
2. Higher dose to the hippocampi may result in long-term neurocognitive impairment.
3. Mean dose of <30 Gy to left hippocampus could be used as a pragmatic dose constraint to prevent long-term neurocognitive decline.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>32227185</pmid><doi>10.1093/neuonc/noaa076</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adolescent Brain Neoplasms - radiotherapy Child Female Glioma Hippocampus Humans Male Pediatric Neuro-Oncology Pituitary Neoplasms Prospective Studies Radiotherapy Dosage Radiotherapy Planning, Computer-Assisted Treatment Outcome |
| title | Hippocampal radiotherapy dose constraints for predicting long-term neurocognitive outcomes: mature data from a prospective trial in young patients with brain tumors |
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