Characterizing diversity in the tumor-immune microenvironment of distinct subclasses of gastroesophageal adenocarcinomas

Gastroesophageal adenocarcinomas (GEAs) are heterogeneous cancers where immune checkpoint inhibitors have robust efficacy in heavily inflamed microsatellite instability (MSI) or Epstein-Barr virus (EBV)-positive subtypes. Immune checkpoint inhibitor responses are markedly lower in diffuse/genome sta...

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Veröffentlicht in:	Annals of oncology 2020-08, Vol.31 (8), p.1011-1020
Hauptverfasser:	Derks, S., de Klerk, L.K., Xu, X., Fleitas, T., Liu, K.X., Liu, Y., Dietlein, F., Margolis, C., Chiaravalli, A.M., Da Silva, A.C., Ogino, S., Akarca, F.G., Freeman, G.J., Rodig, S.J., Hornick, J.L., van Allen, E., Li, B., Liu, S.X., Thorsson, V., Bass, A.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics chromosomal instability gastric cancer subtypes Humans Immunohistochemistry immunotherapy Microsatellite Instability Stomach Neoplasms - genetics tertiary lymphoid structure (TLS) Tumor Microenvironment - genetics
Online-Zugang:	Volltext
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