Clinicopathologic features of kinase fusion-related thyroid carcinomas: an integrative analysis with molecular characterization

The discovery of actionable kinase gene rearrangements has revolutionized the therapeutic landscape of thyroid carcinomas. Unsolved challenges include histopathologic recognition of targetable cases, correlation between genotypes and tumor behavior, and evolving resistance mechanisms against kinase...

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Veröffentlicht in:	Modern pathology 2020-12, Vol.33 (12), p.2458-2472
Hauptverfasser:	Chu, Ying-Hsia, Wirth, Lori J., Farahani, Alexander A., Nosé, Vânia, Faquin, William C., Dias-Santagata, Dora, Sadow, Peter M.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 14/63 45/23 45/91 631/208/68 631/67/1459/1843 Adolescent Adult Aged AKT2 protein Antineoplastic Agents - therapeutic use Biomarkers, Tumor - genetics Carcinoma - enzymology Carcinoma - genetics Carcinoma - secondary Carcinoma - therapy Cdc4 protein Copy number Databases, Factual Disease Progression E-cadherin Enzyme inhibitors Epidermal growth factor receptors Female Fibrosis Gene Fusion Gene Rearrangement Genetic Predisposition to Disease Genotypes Histology Humans Iodine Iodine Radioisotopes - therapeutic use Janus kinase 2 Laboratory Medicine Lymph nodes Male Medicine Medicine & Public Health Metastases Metastasis Middle Aged Molecular Diagnostic Techniques Molecular Targeted Therapy Mutation Neoplasm Recurrence, Local p53 Protein Papillary thyroid carcinoma Pathology Phenotype Protein Kinase Inhibitors - therapeutic use Protein Kinases - genetics Radiopharmaceuticals - therapeutic use Retrospective Studies Thyroid cancer Thyroid gland Thyroid Neoplasms - enzymology Thyroid Neoplasms - genetics Thyroid Neoplasms - pathology Thyroid Neoplasms - therapy Thyroidectomy Time Factors Treatment Outcome Tumors VHL protein Young Adult
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