Human‐engineered Treg‐like cells suppress FOXP3‐deficient T cells but preserve adaptive immune responses in vivo

Objectives Genetic or acquired defects in FOXP3+ regulatory T cells (Tregs) play a key role in many immune‐mediated diseases including immune dysregulation polyendocrinopathy, enteropathy, X‐linked (IPEX) syndrome. Previously, we demonstrated CD4+ T cells from healthy donors and IPEX patients can be...

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Veröffentlicht in:	Clinical & translational immunology 2020, Vol.9 (11), p.e1214-n/a
Hauptverfasser:	Sato, Yohei, Passerini, Laura, Piening, Brian D, Uyeda, Molly Javier, Goodwin, Marianne, Gregori, Silvia, Snyder, Michael P, Bertaina, Alice, Roncarolo, Maria‐Grazia, Bacchetta, Rosa
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Animal models Antigen (tumor-associated) Antigens CD4 antigen Cell proliferation CRISPR/Cas9 Cytokines Disease Effector cells Flow cytometry FOXP3 Foxp3 protein Gene expression gene therapy Genetic engineering Genotype & phenotype Graft-versus-host reaction Immune clearance Immunological memory Immunoregulation Immunosurveillance IPEX syndrome lentiviral vector Lymphocytes Lymphocytes T Medical innovations Medical prognosis Memory cells Original Patients Peripheral blood regulatory T cells Ribonucleic acid RNA T cell receptors Transcription Xenografts
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