Protein-avoidant ionic liquid (PAIL)-coated nanoparticles to increase bloodstream circulation and drive biodistribution
The rapid clearance of intravenously administered nanoparticles (NPs) from the bloodstream is a major unsolved problem in nanomedicine. Here, we describe the first use of biocompatible protein-avoidant ionic liquids (PAILs) as NP surface modifiers to reduce opsonization. An ionic liquid choline hexe...
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| Veröffentlicht in: | Science advances 2020-11, Vol.6 (48) |
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| creator | Hamadani, Christine M Goetz, Morgan J Mitragotri, Samir Tanner, Eden E L |
| description | The rapid clearance of intravenously administered nanoparticles (NPs) from the bloodstream is a major unsolved problem in nanomedicine. Here, we describe the first use of biocompatible protein-avoidant ionic liquids (PAILs) as NP surface modifiers to reduce opsonization. An ionic liquid choline hexenoate, selected for its aversion to serum proteins, was used to stably coat the surface of poly(lactic-
-glycolic acid) (PLGA) NPs. Compared with bare PLGA and poly(ethylene glycol)-coated PLGA particles, the PAIL-PLGA NPs showed resistance to protein adsorption in vitro and greater retention in blood of mice at 24 hours. Choline hexenoate redirected biodistribution of NPs, with preferential accumulation in the lungs with 50% of the administered dose accumulating in the lungs and |
| doi_str_mv | 10.1126/sciadv.abd7563 |
| format | Article |
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-glycolic acid) (PLGA) NPs. Compared with bare PLGA and poly(ethylene glycol)-coated PLGA particles, the PAIL-PLGA NPs showed resistance to protein adsorption in vitro and greater retention in blood of mice at 24 hours. Choline hexenoate redirected biodistribution of NPs, with preferential accumulation in the lungs with 50% of the administered dose accumulating in the lungs and <5% in the liver. Lung accumulation was attributed to spontaneous attachment of the PAIL-coated NPs on red blood cells in vivo. Overall, ionic liquids are a promising class of materials for NP modification for biomedical applications.</description><subject>Animals</subject><subject>Choline</subject><subject>Drug Carriers</subject><subject>Engineering</subject><subject>Health and Medicine</subject><subject>Ionic Liquids</subject><subject>Lactic Acid</subject><subject>Materials Science</subject><subject>Mice</subject><subject>Nanoparticles</subject><subject>Particle Size</subject><subject>Polyglycolic Acid</subject><subject>Polylactic Acid-Polyglycolic Acid Copolymer</subject><subject>SciAdv r-articles</subject><subject>Tissue Distribution</subject><issn>2375-2548</issn><issn>2375-2548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUU1r3DAQFaWhCZtceyw6pgdvZUuW7EshhH4EFppDchZjadxO8UobSd7Qf18vuw3paWZ4b9485jH2vhbrum70p-wI_H4Ngzetlm_YRSNNWzWt6t6-6s_ZVc6_hRC10rqt-3fsXMpG9lI0F-z5PsWCFCrYR_IQCqcYyPGJnmby_Pr-5m7zsXIRCnoeIMQdpEJuwsxL5BRcQsjIhylGn8sybLmj5OYJyiLEIXjuE-0XBkVPC4OG-YBcsrMRpoxXp7pij1-_PNx-rzY_vt3d3mwqJ3tRKtdJr3DQwuDQCW8a08sWDSj0NYydglGhBqd0L2CE1jdoRt1J50zt5QidXLHPR93dPGzROwwlwWR3ibaQ_tgIZP9HAv2yP-PeGt11UopF4PokkOLTjLnYLWWH0wQB45xto7Ra7B3-uWLrI9WlmHPC8eVMLewhMHsMzJ4CWxY-vDb3Qv8Xj_wLxDuX8A</recordid><startdate>20201101</startdate><enddate>20201101</enddate><creator>Hamadani, Christine M</creator><creator>Goetz, Morgan J</creator><creator>Mitragotri, Samir</creator><creator>Tanner, Eden E L</creator><general>American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4774-6777</orcidid><orcidid>https://orcid.org/0000-0002-7919-2249</orcidid><orcidid>https://orcid.org/0000-0002-2459-8305</orcidid></search><sort><creationdate>20201101</creationdate><title>Protein-avoidant ionic liquid (PAIL)-coated nanoparticles to increase bloodstream circulation and drive biodistribution</title><author>Hamadani, Christine M ; Goetz, Morgan J ; Mitragotri, Samir ; Tanner, Eden E L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-c83d4eb607eb80d727935e7a4ed1af84af4e6ac4690afa5d2e7f683cc71d3fa83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Choline</topic><topic>Drug Carriers</topic><topic>Engineering</topic><topic>Health and Medicine</topic><topic>Ionic Liquids</topic><topic>Lactic Acid</topic><topic>Materials Science</topic><topic>Mice</topic><topic>Nanoparticles</topic><topic>Particle Size</topic><topic>Polyglycolic Acid</topic><topic>Polylactic Acid-Polyglycolic Acid Copolymer</topic><topic>SciAdv r-articles</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hamadani, Christine M</creatorcontrib><creatorcontrib>Goetz, Morgan J</creatorcontrib><creatorcontrib>Mitragotri, Samir</creatorcontrib><creatorcontrib>Tanner, Eden E L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Science advances</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hamadani, Christine M</au><au>Goetz, Morgan J</au><au>Mitragotri, Samir</au><au>Tanner, Eden E L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protein-avoidant ionic liquid (PAIL)-coated nanoparticles to increase bloodstream circulation and drive biodistribution</atitle><jtitle>Science advances</jtitle><addtitle>Sci Adv</addtitle><date>2020-11-01</date><risdate>2020</risdate><volume>6</volume><issue>48</issue><issn>2375-2548</issn><eissn>2375-2548</eissn><abstract>The rapid clearance of intravenously administered nanoparticles (NPs) from the bloodstream is a major unsolved problem in nanomedicine. 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-glycolic acid) (PLGA) NPs. Compared with bare PLGA and poly(ethylene glycol)-coated PLGA particles, the PAIL-PLGA NPs showed resistance to protein adsorption in vitro and greater retention in blood of mice at 24 hours. Choline hexenoate redirected biodistribution of NPs, with preferential accumulation in the lungs with 50% of the administered dose accumulating in the lungs and <5% in the liver. Lung accumulation was attributed to spontaneous attachment of the PAIL-coated NPs on red blood cells in vivo. Overall, ionic liquids are a promising class of materials for NP modification for biomedical applications.</abstract><cop>United States</cop><pub>American Association for the Advancement of Science</pub><pmid>33239302</pmid><doi>10.1126/sciadv.abd7563</doi><orcidid>https://orcid.org/0000-0003-4774-6777</orcidid><orcidid>https://orcid.org/0000-0002-7919-2249</orcidid><orcidid>https://orcid.org/0000-0002-2459-8305</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Choline Drug Carriers Engineering Health and Medicine Ionic Liquids Lactic Acid Materials Science Mice Nanoparticles Particle Size Polyglycolic Acid Polylactic Acid-Polyglycolic Acid Copolymer SciAdv r-articles Tissue Distribution |
| title | Protein-avoidant ionic liquid (PAIL)-coated nanoparticles to increase bloodstream circulation and drive biodistribution |
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