CircRNA0001859, a new diagnostic and prognostic biomarkers for COPD and AECOPD
Background Dysregulation of circRNAs has been reported to be functionally associated with chronic obstructive pulmonary disease (COPD). The present investigation elucidated the potential role of CircRNA0001859 in regulating chronic obstructive pulmonary disease acute (COPD) and Acute Exacerbation of...
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| Veröffentlicht in: | BMC pulmonary medicine 2020-11, Vol.20 (1), p.1-311, Article 311 |
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| description | Background Dysregulation of circRNAs has been reported to be functionally associated with chronic obstructive pulmonary disease (COPD). The present investigation elucidated the potential role of CircRNA0001859 in regulating chronic obstructive pulmonary disease acute (COPD) and Acute Exacerbation of COPD (AECOPD). Methods Mice model of COPD was established to screen and verify the dysregulated expression of CircRNA0001859. Fluorescence in situ hybridization (FISH) and quantitative real-time PCR (qRT-PCR) were carried out to detect the expression of CircRNA0001859. 38 stable COPD patients, 24 AECOPD patients, 57 COPD with lung cancer patients and 28 healthy person with age and sex matched to total patients were used for the present investigation. Results circRNA0001859 was downregulated in the lung tissue of mice after the three kinds of treatments (Cigarette smoke (CS)/NK alone or CS + NNK) for inducing COPD. FISH assay verified the downregulation of circRNA0001859 both in the mice lung and human bronchial epithelial cell of COPD model. Furthermore,, the level of circRNA0001859 was also downregulated in the peripheral blood of COPD and lung cancer patients. CircRNA0001859 might act as a diagnostic and prognostic biomarker for the treatment of in COPD and AECOPD with Are under the receiver operating characteristic curve (ROC curve) (AUC) of 0.7433 and 0.8717, respectively. Conclusion We explored a novel circRNA0001859, which might act as a potential therapeutic biomarker for the treatment of COPD and AECOPD. Keywords: Circular RNA0001859 (CircRNA0001859), CS, NNK, Chronic obstructive pulmonary disease (COPD), Acute exacerbation of COPD (AECOPD), Lung cancer |
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The present investigation elucidated the potential role of CircRNA0001859 in regulating chronic obstructive pulmonary disease acute (COPD) and Acute Exacerbation of COPD (AECOPD). Methods Mice model of COPD was established to screen and verify the dysregulated expression of CircRNA0001859. Fluorescence in situ hybridization (FISH) and quantitative real-time PCR (qRT-PCR) were carried out to detect the expression of CircRNA0001859. 38 stable COPD patients, 24 AECOPD patients, 57 COPD with lung cancer patients and 28 healthy person with age and sex matched to total patients were used for the present investigation. Results circRNA0001859 was downregulated in the lung tissue of mice after the three kinds of treatments (Cigarette smoke (CS)/NK alone or CS + NNK) for inducing COPD. FISH assay verified the downregulation of circRNA0001859 both in the mice lung and human bronchial epithelial cell of COPD model. Furthermore,, the level of circRNA0001859 was also downregulated in the peripheral blood of COPD and lung cancer patients. CircRNA0001859 might act as a diagnostic and prognostic biomarker for the treatment of in COPD and AECOPD with Are under the receiver operating characteristic curve (ROC curve) (AUC) of 0.7433 and 0.8717, respectively. Conclusion We explored a novel circRNA0001859, which might act as a potential therapeutic biomarker for the treatment of COPD and AECOPD. Keywords: Circular RNA0001859 (CircRNA0001859), CS, NNK, Chronic obstructive pulmonary disease (COPD), Acute exacerbation of COPD (AECOPD), Lung cancer</description><identifier>ISSN: 1471-2466</identifier><identifier>EISSN: 1471-2466</identifier><identifier>DOI: 10.1186/s12890-020-01333-1</identifier><identifier>PMID: 33239003</identifier><language>eng</language><publisher>London: BioMed Central Ltd</publisher><subject>Age ; Autoimmune diseases ; Biological markers ; Biomarkers ; Cell cycle ; Chronic obstructive pulmonary disease ; Cigarette smoke ; Cigarettes ; Coronaviruses ; COVID-19 ; Cytokines ; Diagnosis ; Drug dosages ; Epithelial cells ; Ethics ; Fluorescence in situ hybridization ; Genetic aspects ; Health aspects ; Humidity ; Hypertension ; Infections ; Lavage ; Lung cancer ; Lung diseases ; Lung diseases, Obstructive ; Medical research ; Obstructive lung disease ; Peripheral blood ; Pulmonary arteries ; Pulmonology ; RNA ; Tuberculosis ; Tumor necrosis factor-TNF</subject><ispartof>BMC pulmonary medicine, 2020-11, Vol.20 (1), p.1-311, Article 311</ispartof><rights>COPYRIGHT 2020 BioMed Central Ltd.</rights><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-9653c126c03f0ce10424daf4ebbe648f91c49c1e492666f97838a92152ca94b73</citedby><cites>FETCH-LOGICAL-c474t-9653c126c03f0ce10424daf4ebbe648f91c49c1e492666f97838a92152ca94b73</cites><orcidid>0000-0001-8463-0365</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7688204/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7688204/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids></links><search><creatorcontrib>Chen, Shuifang</creatorcontrib><creatorcontrib>Yao, Yinan</creatorcontrib><creatorcontrib>Lu, Shan</creatorcontrib><creatorcontrib>Chen, Junjun</creatorcontrib><creatorcontrib>Yang, Guangdie</creatorcontrib><creatorcontrib>Tu, Lingfang</creatorcontrib><creatorcontrib>Chen, Lina</creatorcontrib><title>CircRNA0001859, a new diagnostic and prognostic biomarkers for COPD and AECOPD</title><title>BMC pulmonary medicine</title><description>Background Dysregulation of circRNAs has been reported to be functionally associated with chronic obstructive pulmonary disease (COPD). The present investigation elucidated the potential role of CircRNA0001859 in regulating chronic obstructive pulmonary disease acute (COPD) and Acute Exacerbation of COPD (AECOPD). Methods Mice model of COPD was established to screen and verify the dysregulated expression of CircRNA0001859. Fluorescence in situ hybridization (FISH) and quantitative real-time PCR (qRT-PCR) were carried out to detect the expression of CircRNA0001859. 38 stable COPD patients, 24 AECOPD patients, 57 COPD with lung cancer patients and 28 healthy person with age and sex matched to total patients were used for the present investigation. Results circRNA0001859 was downregulated in the lung tissue of mice after the three kinds of treatments (Cigarette smoke (CS)/NK alone or CS + NNK) for inducing COPD. FISH assay verified the downregulation of circRNA0001859 both in the mice lung and human bronchial epithelial cell of COPD model. Furthermore,, the level of circRNA0001859 was also downregulated in the peripheral blood of COPD and lung cancer patients. CircRNA0001859 might act as a diagnostic and prognostic biomarker for the treatment of in COPD and AECOPD with Are under the receiver operating characteristic curve (ROC curve) (AUC) of 0.7433 and 0.8717, respectively. Conclusion We explored a novel circRNA0001859, which might act as a potential therapeutic biomarker for the treatment of COPD and AECOPD. Keywords: Circular RNA0001859 (CircRNA0001859), CS, NNK, Chronic obstructive pulmonary disease (COPD), Acute exacerbation of COPD (AECOPD), Lung cancer</description><subject>Age</subject><subject>Autoimmune diseases</subject><subject>Biological markers</subject><subject>Biomarkers</subject><subject>Cell cycle</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Cigarette smoke</subject><subject>Cigarettes</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Cytokines</subject><subject>Diagnosis</subject><subject>Drug dosages</subject><subject>Epithelial cells</subject><subject>Ethics</subject><subject>Fluorescence in situ hybridization</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Humidity</subject><subject>Hypertension</subject><subject>Infections</subject><subject>Lavage</subject><subject>Lung cancer</subject><subject>Lung diseases</subject><subject>Lung diseases, Obstructive</subject><subject>Medical research</subject><subject>Obstructive lung disease</subject><subject>Peripheral blood</subject><subject>Pulmonary arteries</subject><subject>Pulmonology</subject><subject>RNA</subject><subject>Tuberculosis</subject><subject>Tumor necrosis factor-TNF</subject><issn>1471-2466</issn><issn>1471-2466</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptkl1PHCEUholpo9b6B7yapDe9cCwHGD5ummxWW02MmkavCcPAip2FLexq_PdlXW1rYwjhwHnOC4e8CB0APgKQ_EsBIhVuMakTKKUtbKFdYAJawjh_90-8gz6UcocxCNnRbbRDKaEKY7qLLqYh2x8XE1yTslOHjWmie2iGYGYxlWWwjYlDs8jpZduHNDf5p8ul8Sk308ur4ydkcrIOP6L33ozF7T-ve-jm28n19LQ9v_x-Np2ct5YJtmwV76gFwi2mHlsHmBE2GM9c3zvOpFdgmbLgmCKcc6-EpNIoAh2xRrFe0D30daO7WPVzN1gXl9mMepFDfdyjTibo15kYbvUs3WvBpSSYVYHPzwI5_Vq5stTzUKwbRxNdWhVdf41xLIggFf30H3qXVjnW9ioloL4KQPylZmZ0OkSf6r12LaonvMOcV2ZNHb1B1TG4ebApOh_q-asCsimwOZWSnf_TI2C9doHeuEBXF-gnF2igvwEYLp5o</recordid><startdate>20201125</startdate><enddate>20201125</enddate><creator>Chen, Shuifang</creator><creator>Yao, Yinan</creator><creator>Lu, Shan</creator><creator>Chen, Junjun</creator><creator>Yang, Guangdie</creator><creator>Tu, Lingfang</creator><creator>Chen, Lina</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8463-0365</orcidid></search><sort><creationdate>20201125</creationdate><title>CircRNA0001859, a new diagnostic and prognostic biomarkers for COPD and AECOPD</title><author>Chen, Shuifang ; Yao, Yinan ; Lu, Shan ; Chen, Junjun ; Yang, Guangdie ; Tu, Lingfang ; Chen, Lina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-9653c126c03f0ce10424daf4ebbe648f91c49c1e492666f97838a92152ca94b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Age</topic><topic>Autoimmune diseases</topic><topic>Biological markers</topic><topic>Biomarkers</topic><topic>Cell cycle</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Cigarette smoke</topic><topic>Cigarettes</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>Cytokines</topic><topic>Diagnosis</topic><topic>Drug dosages</topic><topic>Epithelial cells</topic><topic>Ethics</topic><topic>Fluorescence in situ hybridization</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>Humidity</topic><topic>Hypertension</topic><topic>Infections</topic><topic>Lavage</topic><topic>Lung cancer</topic><topic>Lung diseases</topic><topic>Lung diseases, Obstructive</topic><topic>Medical research</topic><topic>Obstructive lung disease</topic><topic>Peripheral blood</topic><topic>Pulmonary arteries</topic><topic>Pulmonology</topic><topic>RNA</topic><topic>Tuberculosis</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Shuifang</creatorcontrib><creatorcontrib>Yao, Yinan</creatorcontrib><creatorcontrib>Lu, Shan</creatorcontrib><creatorcontrib>Chen, Junjun</creatorcontrib><creatorcontrib>Yang, Guangdie</creatorcontrib><creatorcontrib>Tu, Lingfang</creatorcontrib><creatorcontrib>Chen, Lina</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC pulmonary medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Shuifang</au><au>Yao, Yinan</au><au>Lu, Shan</au><au>Chen, Junjun</au><au>Yang, Guangdie</au><au>Tu, Lingfang</au><au>Chen, Lina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CircRNA0001859, a new diagnostic and prognostic biomarkers for COPD and AECOPD</atitle><jtitle>BMC pulmonary medicine</jtitle><date>2020-11-25</date><risdate>2020</risdate><volume>20</volume><issue>1</issue><spage>1</spage><epage>311</epage><pages>1-311</pages><artnum>311</artnum><issn>1471-2466</issn><eissn>1471-2466</eissn><abstract>Background Dysregulation of circRNAs has been reported to be functionally associated with chronic obstructive pulmonary disease (COPD). The present investigation elucidated the potential role of CircRNA0001859 in regulating chronic obstructive pulmonary disease acute (COPD) and Acute Exacerbation of COPD (AECOPD). Methods Mice model of COPD was established to screen and verify the dysregulated expression of CircRNA0001859. Fluorescence in situ hybridization (FISH) and quantitative real-time PCR (qRT-PCR) were carried out to detect the expression of CircRNA0001859. 38 stable COPD patients, 24 AECOPD patients, 57 COPD with lung cancer patients and 28 healthy person with age and sex matched to total patients were used for the present investigation. Results circRNA0001859 was downregulated in the lung tissue of mice after the three kinds of treatments (Cigarette smoke (CS)/NK alone or CS + NNK) for inducing COPD. FISH assay verified the downregulation of circRNA0001859 both in the mice lung and human bronchial epithelial cell of COPD model. Furthermore,, the level of circRNA0001859 was also downregulated in the peripheral blood of COPD and lung cancer patients. CircRNA0001859 might act as a diagnostic and prognostic biomarker for the treatment of in COPD and AECOPD with Are under the receiver operating characteristic curve (ROC curve) (AUC) of 0.7433 and 0.8717, respectively. Conclusion We explored a novel circRNA0001859, which might act as a potential therapeutic biomarker for the treatment of COPD and AECOPD. Keywords: Circular RNA0001859 (CircRNA0001859), CS, NNK, Chronic obstructive pulmonary disease (COPD), Acute exacerbation of COPD (AECOPD), Lung cancer</abstract><cop>London</cop><pub>BioMed Central Ltd</pub><pmid>33239003</pmid><doi>10.1186/s12890-020-01333-1</doi><orcidid>https://orcid.org/0000-0001-8463-0365</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Age Autoimmune diseases Biological markers Biomarkers Cell cycle Chronic obstructive pulmonary disease Cigarette smoke Cigarettes Coronaviruses COVID-19 Cytokines Diagnosis Drug dosages Epithelial cells Ethics Fluorescence in situ hybridization Genetic aspects Health aspects Humidity Hypertension Infections Lavage Lung cancer Lung diseases Lung diseases, Obstructive Medical research Obstructive lung disease Peripheral blood Pulmonary arteries Pulmonology RNA Tuberculosis Tumor necrosis factor-TNF |
| title | CircRNA0001859, a new diagnostic and prognostic biomarkers for COPD and AECOPD |
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