Genetic ablation of serotonin receptor 2B improves aortic valve hemodynamics of Notch1 heterozygous mice in a high-cholesterol diet model

Calcific aortic valve disease (CAVD) is a deadly disease that is rising in prevalence due to population aging. While the disease is complex and poorly understood, one well-documented driver of valvulopathy is serotonin agonism. Both serotonin overexpression, as seen with carcinoid tumors and drug-re...

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Veröffentlicht in:	PloS one 2020-11, Vol.15 (11), p.e0238407, Article 0238407
Hauptverfasser:	Joll, J. Ethan, Clark, Cynthia R., Peters, Christine S., Raddatz, Michael A., Bersi, Matthew R., Merryman, W. David
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Ablation (Surgery) Age Aging Animal models Animals Aorta Aortic valve Aortic Valve - pathology Aortic valve stenosis Aortic Valve Stenosis - genetics Aortic Valve Stenosis - pathology Biology and Life Sciences Biomedical engineering Calcification Calcinosis - genetics Calcinosis - pathology Cardiac function Cardiovascular disease Care and treatment Cholesterol Cholesterol - metabolism Collagen Development and progression Diagnosis Diet Disease Models, Animal Disease Progression Dosage and administration Echocardiography Echocardiography - methods Engineering Fenfluramine Gene expression Genetic aspects Genotype & phenotype Heart Valve Diseases - genetics Heart Valve Diseases - pathology Heart valves Hemodynamics Hemodynamics - genetics Hemodynamics - physiology High cholesterol diet Histology Hypercholesterolemia - genetics Hypercholesterolemia - pathology Hyperlipidemias - genetics Hyperlipidemias - pathology Immunofluorescence Medicine and Health Sciences Mice Multidisciplinary Sciences Mutants Notch1 protein Pharmacology Polymerase chain reaction Receptor, Notch1 - genetics Receptor, Serotonin, 5-HT2B - genetics Receptors Research and Analysis Methods Science & Technology Science & Technology - Other Topics Serotonin Serotonin receptors Serotonin S2 receptors Stenosis Transcription Tumors Ventricle
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