Transplantation of a heart donated after circulatory death via thoraco-abdominal normothermic regional perfusion and results from the first Spanish case
Controlled donation after circulatory death (cDCD) has emerged as one of the main strategies for increasing the organ donor pool. Because of the ischemic injury that follows the withdrawal of life-sustaining therapies, hearts from cDCD donors have not been considered for transplantation until recent...
Gespeichert in:
| Veröffentlicht in: | Journal of cardiothoracic surgery 2020-11, Vol.15 (1), p.333-333, Article 333 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 333 |
|---|---|
| container_issue | 1 |
| container_start_page | 333 |
| container_title | Journal of cardiothoracic surgery |
| container_volume | 15 |
| creator | Pérez Redondo, Marina Alcántara Carmona, Sara Villar García, Susana Forteza Gil, Alberto Villanueva Fernández, Héctor Hernández-Pérez, Francisco José Campo-Cañaveral de la Cruz, José Luis Velasco Calvo, Rocío Segovia-Cubero, Javier Alonso Menárguez, Beatriz Del Río Gallegos, Francisco Coll, Elisabeth Domínguez-Gil González, Beatriz Rubio Muñoz, Juan José |
| description | Controlled donation after circulatory death (cDCD) has emerged as one of the main strategies for increasing the organ donor pool. Because of the ischemic injury that follows the withdrawal of life-sustaining therapies, hearts from cDCD donors have not been considered for transplantation until recently. The ex-situ perfusion of hearts directly procured from cDCD donors has been used to allow the continuous perfusion of the organ and the assessment of myocardial viability prior to transplantation. Based on our experience with abdominal normothermic regional perfusion in cDCD, we designed a protocol to recover and validate hearts from cDCD donors using thoraco-abdominal normothermic regional perfusion without the utilization of an ex-situ device.
We describe the first case of a cDCD heart transplant performed with this approach in Spain. The donor was a 43-year-old asthmatic female diagnosed with severe hypoxic encephalopathy. She was considered a potential cDCD donor and a suitable candidate for multiorgan procurement including the heart via thoraco-abdominal normothermic regional perfusion. The heart recipient was a 60-year-old male diagnosed with amyloid cardiomyopathy. Cold ischemia time was 55 min. The surgery was uneventful.
This case report, the first of its kind in Spain, supports the feasibility of evaluating and successfully transplanting cDCD hearts without the need for ex-situ perfusion based on the use of thoraco-abdominal normothermic regional perfusion opening the way for multiorgan donation in cDCD. |
| doi_str_mv | 10.1186/s13019-020-01372-z |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7687983</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A650661703</galeid><sourcerecordid>A650661703</sourcerecordid><originalsourceid>FETCH-LOGICAL-c497t-9b098c0946d525880ef83a93d595d8cb14747ee748fa4652e5214e95e979cea33</originalsourceid><addsrcrecordid>eNptUk1rFTEUHUSxtfoHXEjAjZupySQzSTZCKVqFggvrOtyXufMmZSZ5JplC-0v6c8301dqKZJFwcz64h1NVbxk9Zkx1HxPjlOmaNrSmjMumvnlWHTIpdK2ops8fvQ-qVyldUipaTtuX1QHnDddUdYfV7UUEn3YT-AzZBU_CQICMCDGTPnjI2BMYMkZiXbTLBDnEa9Ij5JFcOSB5DBFsqGHTh9l5mIgPcQ55xDg7SyJui2iZ7jAOS1oNwPdlnJYpJzLEMBcJJIOLKZMfO_AujcRCwtfViwGmhG_u76Pq55fPF6df6_PvZ99OT85rK7TMtd5QrSzVouvbplWK4qA4aN63uu2V3TAhhUSUQg0gurbBtmECdYtaaovA-VH1aa-7WzYz9hZ9jjCZXXQzxGsTwJmnP96NZhuujOyU1GoV-HAvEMOvBVM2s0sWpxIphiWZRnSio4q2TYG-_wd6GZZY4llRkrFGSt79RW1hQuP8EIqvXUXNSdfSrmOSrrbH_0GV02MJPngcXJk_ITR7go0hpYjDw46MmrVPZt8nU_pk7vpkbgrp3eN0Hih_CsR_A1w-yNc</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2471127736</pqid></control><display><type>article</type><title>Transplantation of a heart donated after circulatory death via thoraco-abdominal normothermic regional perfusion and results from the first Spanish case</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>SpringerLink Journals</source><source>PubMed Central Open Access</source><source>Springer Nature OA Free Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Pérez Redondo, Marina ; Alcántara Carmona, Sara ; Villar García, Susana ; Forteza Gil, Alberto ; Villanueva Fernández, Héctor ; Hernández-Pérez, Francisco José ; Campo-Cañaveral de la Cruz, José Luis ; Velasco Calvo, Rocío ; Segovia-Cubero, Javier ; Alonso Menárguez, Beatriz ; Del Río Gallegos, Francisco ; Coll, Elisabeth ; Domínguez-Gil González, Beatriz ; Rubio Muñoz, Juan José</creator><creatorcontrib>Pérez Redondo, Marina ; Alcántara Carmona, Sara ; Villar García, Susana ; Forteza Gil, Alberto ; Villanueva Fernández, Héctor ; Hernández-Pérez, Francisco José ; Campo-Cañaveral de la Cruz, José Luis ; Velasco Calvo, Rocío ; Segovia-Cubero, Javier ; Alonso Menárguez, Beatriz ; Del Río Gallegos, Francisco ; Coll, Elisabeth ; Domínguez-Gil González, Beatriz ; Rubio Muñoz, Juan José</creatorcontrib><description>Controlled donation after circulatory death (cDCD) has emerged as one of the main strategies for increasing the organ donor pool. Because of the ischemic injury that follows the withdrawal of life-sustaining therapies, hearts from cDCD donors have not been considered for transplantation until recently. The ex-situ perfusion of hearts directly procured from cDCD donors has been used to allow the continuous perfusion of the organ and the assessment of myocardial viability prior to transplantation. Based on our experience with abdominal normothermic regional perfusion in cDCD, we designed a protocol to recover and validate hearts from cDCD donors using thoraco-abdominal normothermic regional perfusion without the utilization of an ex-situ device.
We describe the first case of a cDCD heart transplant performed with this approach in Spain. The donor was a 43-year-old asthmatic female diagnosed with severe hypoxic encephalopathy. She was considered a potential cDCD donor and a suitable candidate for multiorgan procurement including the heart via thoraco-abdominal normothermic regional perfusion. The heart recipient was a 60-year-old male diagnosed with amyloid cardiomyopathy. Cold ischemia time was 55 min. The surgery was uneventful.
This case report, the first of its kind in Spain, supports the feasibility of evaluating and successfully transplanting cDCD hearts without the need for ex-situ perfusion based on the use of thoraco-abdominal normothermic regional perfusion opening the way for multiorgan donation in cDCD.</description><identifier>ISSN: 1749-8090</identifier><identifier>EISSN: 1749-8090</identifier><identifier>DOI: 10.1186/s13019-020-01372-z</identifier><identifier>PMID: 33239086</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Abdomen ; Adult ; Amyloid ; Anesthesia ; Asthma ; Blood & organ donations ; Cardiomyopathy ; Case Report ; Catheters ; Death ; Encephalopathy ; Extracorporeal Membrane Oxygenation ; Female ; Heart ; Heart Transplantation ; Hospitals ; Humans ; Hypoxia ; Intensive care ; Ischemia ; Kidneys ; Liver ; Male ; Middle Aged ; Organ donors ; Perfusion ; Perfusion - methods ; Spain ; Surgery ; Thoracic surgery ; Thorax ; Tissue and Organ Harvesting - methods ; Tissue Donors ; Transplantation ; Transplants & implants ; Ultrasonic imaging ; Veins & arteries</subject><ispartof>Journal of cardiothoracic surgery, 2020-11, Vol.15 (1), p.333-333, Article 333</ispartof><rights>COPYRIGHT 2020 BioMed Central Ltd.</rights><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c497t-9b098c0946d525880ef83a93d595d8cb14747ee748fa4652e5214e95e979cea33</citedby><cites>FETCH-LOGICAL-c497t-9b098c0946d525880ef83a93d595d8cb14747ee748fa4652e5214e95e979cea33</cites><orcidid>0000-0002-4606-3416 ; 0000-0003-0847-0392 ; 0000-0001-7325-8473 ; 0000-0002-2889-4312 ; 0000-0002-5695-8993 ; 0000-0001-6811-132X ; 0000-0001-6343-8112 ; 0000-0002-3941-5743 ; 0000-0003-3496-875X ; 0000-0003-0338-9253 ; 0000-0001-9221-2307 ; 0000-0001-7572-4685 ; 0000-0002-8591-0120 ; 0000-0001-6876-7476</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687983/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687983/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33239086$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pérez Redondo, Marina</creatorcontrib><creatorcontrib>Alcántara Carmona, Sara</creatorcontrib><creatorcontrib>Villar García, Susana</creatorcontrib><creatorcontrib>Forteza Gil, Alberto</creatorcontrib><creatorcontrib>Villanueva Fernández, Héctor</creatorcontrib><creatorcontrib>Hernández-Pérez, Francisco José</creatorcontrib><creatorcontrib>Campo-Cañaveral de la Cruz, José Luis</creatorcontrib><creatorcontrib>Velasco Calvo, Rocío</creatorcontrib><creatorcontrib>Segovia-Cubero, Javier</creatorcontrib><creatorcontrib>Alonso Menárguez, Beatriz</creatorcontrib><creatorcontrib>Del Río Gallegos, Francisco</creatorcontrib><creatorcontrib>Coll, Elisabeth</creatorcontrib><creatorcontrib>Domínguez-Gil González, Beatriz</creatorcontrib><creatorcontrib>Rubio Muñoz, Juan José</creatorcontrib><title>Transplantation of a heart donated after circulatory death via thoraco-abdominal normothermic regional perfusion and results from the first Spanish case</title><title>Journal of cardiothoracic surgery</title><addtitle>J Cardiothorac Surg</addtitle><description>Controlled donation after circulatory death (cDCD) has emerged as one of the main strategies for increasing the organ donor pool. Because of the ischemic injury that follows the withdrawal of life-sustaining therapies, hearts from cDCD donors have not been considered for transplantation until recently. The ex-situ perfusion of hearts directly procured from cDCD donors has been used to allow the continuous perfusion of the organ and the assessment of myocardial viability prior to transplantation. Based on our experience with abdominal normothermic regional perfusion in cDCD, we designed a protocol to recover and validate hearts from cDCD donors using thoraco-abdominal normothermic regional perfusion without the utilization of an ex-situ device.
We describe the first case of a cDCD heart transplant performed with this approach in Spain. The donor was a 43-year-old asthmatic female diagnosed with severe hypoxic encephalopathy. She was considered a potential cDCD donor and a suitable candidate for multiorgan procurement including the heart via thoraco-abdominal normothermic regional perfusion. The heart recipient was a 60-year-old male diagnosed with amyloid cardiomyopathy. Cold ischemia time was 55 min. The surgery was uneventful.
This case report, the first of its kind in Spain, supports the feasibility of evaluating and successfully transplanting cDCD hearts without the need for ex-situ perfusion based on the use of thoraco-abdominal normothermic regional perfusion opening the way for multiorgan donation in cDCD.</description><subject>Abdomen</subject><subject>Adult</subject><subject>Amyloid</subject><subject>Anesthesia</subject><subject>Asthma</subject><subject>Blood & organ donations</subject><subject>Cardiomyopathy</subject><subject>Case Report</subject><subject>Catheters</subject><subject>Death</subject><subject>Encephalopathy</subject><subject>Extracorporeal Membrane Oxygenation</subject><subject>Female</subject><subject>Heart</subject><subject>Heart Transplantation</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Intensive care</subject><subject>Ischemia</subject><subject>Kidneys</subject><subject>Liver</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Organ donors</subject><subject>Perfusion</subject><subject>Perfusion - methods</subject><subject>Spain</subject><subject>Surgery</subject><subject>Thoracic surgery</subject><subject>Thorax</subject><subject>Tissue and Organ Harvesting - methods</subject><subject>Tissue Donors</subject><subject>Transplantation</subject><subject>Transplants & implants</subject><subject>Ultrasonic imaging</subject><subject>Veins & arteries</subject><issn>1749-8090</issn><issn>1749-8090</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptUk1rFTEUHUSxtfoHXEjAjZupySQzSTZCKVqFggvrOtyXufMmZSZ5JplC-0v6c8301dqKZJFwcz64h1NVbxk9Zkx1HxPjlOmaNrSmjMumvnlWHTIpdK2ops8fvQ-qVyldUipaTtuX1QHnDddUdYfV7UUEn3YT-AzZBU_CQICMCDGTPnjI2BMYMkZiXbTLBDnEa9Ij5JFcOSB5DBFsqGHTh9l5mIgPcQ55xDg7SyJui2iZ7jAOS1oNwPdlnJYpJzLEMBcJJIOLKZMfO_AujcRCwtfViwGmhG_u76Pq55fPF6df6_PvZ99OT85rK7TMtd5QrSzVouvbplWK4qA4aN63uu2V3TAhhUSUQg0gurbBtmECdYtaaovA-VH1aa-7WzYz9hZ9jjCZXXQzxGsTwJmnP96NZhuujOyU1GoV-HAvEMOvBVM2s0sWpxIphiWZRnSio4q2TYG-_wd6GZZY4llRkrFGSt79RW1hQuP8EIqvXUXNSdfSrmOSrrbH_0GV02MJPngcXJk_ITR7go0hpYjDw46MmrVPZt8nU_pk7vpkbgrp3eN0Hih_CsR_A1w-yNc</recordid><startdate>20201125</startdate><enddate>20201125</enddate><creator>Pérez Redondo, Marina</creator><creator>Alcántara Carmona, Sara</creator><creator>Villar García, Susana</creator><creator>Forteza Gil, Alberto</creator><creator>Villanueva Fernández, Héctor</creator><creator>Hernández-Pérez, Francisco José</creator><creator>Campo-Cañaveral de la Cruz, José Luis</creator><creator>Velasco Calvo, Rocío</creator><creator>Segovia-Cubero, Javier</creator><creator>Alonso Menárguez, Beatriz</creator><creator>Del Río Gallegos, Francisco</creator><creator>Coll, Elisabeth</creator><creator>Domínguez-Gil González, Beatriz</creator><creator>Rubio Muñoz, Juan José</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7Z</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4606-3416</orcidid><orcidid>https://orcid.org/0000-0003-0847-0392</orcidid><orcidid>https://orcid.org/0000-0001-7325-8473</orcidid><orcidid>https://orcid.org/0000-0002-2889-4312</orcidid><orcidid>https://orcid.org/0000-0002-5695-8993</orcidid><orcidid>https://orcid.org/0000-0001-6811-132X</orcidid><orcidid>https://orcid.org/0000-0001-6343-8112</orcidid><orcidid>https://orcid.org/0000-0002-3941-5743</orcidid><orcidid>https://orcid.org/0000-0003-3496-875X</orcidid><orcidid>https://orcid.org/0000-0003-0338-9253</orcidid><orcidid>https://orcid.org/0000-0001-9221-2307</orcidid><orcidid>https://orcid.org/0000-0001-7572-4685</orcidid><orcidid>https://orcid.org/0000-0002-8591-0120</orcidid><orcidid>https://orcid.org/0000-0001-6876-7476</orcidid></search><sort><creationdate>20201125</creationdate><title>Transplantation of a heart donated after circulatory death via thoraco-abdominal normothermic regional perfusion and results from the first Spanish case</title><author>Pérez Redondo, Marina ; Alcántara Carmona, Sara ; Villar García, Susana ; Forteza Gil, Alberto ; Villanueva Fernández, Héctor ; Hernández-Pérez, Francisco José ; Campo-Cañaveral de la Cruz, José Luis ; Velasco Calvo, Rocío ; Segovia-Cubero, Javier ; Alonso Menárguez, Beatriz ; Del Río Gallegos, Francisco ; Coll, Elisabeth ; Domínguez-Gil González, Beatriz ; Rubio Muñoz, Juan José</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c497t-9b098c0946d525880ef83a93d595d8cb14747ee748fa4652e5214e95e979cea33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Abdomen</topic><topic>Adult</topic><topic>Amyloid</topic><topic>Anesthesia</topic><topic>Asthma</topic><topic>Blood & organ donations</topic><topic>Cardiomyopathy</topic><topic>Case Report</topic><topic>Catheters</topic><topic>Death</topic><topic>Encephalopathy</topic><topic>Extracorporeal Membrane Oxygenation</topic><topic>Female</topic><topic>Heart</topic><topic>Heart Transplantation</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypoxia</topic><topic>Intensive care</topic><topic>Ischemia</topic><topic>Kidneys</topic><topic>Liver</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Organ donors</topic><topic>Perfusion</topic><topic>Perfusion - methods</topic><topic>Spain</topic><topic>Surgery</topic><topic>Thoracic surgery</topic><topic>Thorax</topic><topic>Tissue and Organ Harvesting - methods</topic><topic>Tissue Donors</topic><topic>Transplantation</topic><topic>Transplants & implants</topic><topic>Ultrasonic imaging</topic><topic>Veins & arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pérez Redondo, Marina</creatorcontrib><creatorcontrib>Alcántara Carmona, Sara</creatorcontrib><creatorcontrib>Villar García, Susana</creatorcontrib><creatorcontrib>Forteza Gil, Alberto</creatorcontrib><creatorcontrib>Villanueva Fernández, Héctor</creatorcontrib><creatorcontrib>Hernández-Pérez, Francisco José</creatorcontrib><creatorcontrib>Campo-Cañaveral de la Cruz, José Luis</creatorcontrib><creatorcontrib>Velasco Calvo, Rocío</creatorcontrib><creatorcontrib>Segovia-Cubero, Javier</creatorcontrib><creatorcontrib>Alonso Menárguez, Beatriz</creatorcontrib><creatorcontrib>Del Río Gallegos, Francisco</creatorcontrib><creatorcontrib>Coll, Elisabeth</creatorcontrib><creatorcontrib>Domínguez-Gil González, Beatriz</creatorcontrib><creatorcontrib>Rubio Muñoz, Juan José</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of cardiothoracic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pérez Redondo, Marina</au><au>Alcántara Carmona, Sara</au><au>Villar García, Susana</au><au>Forteza Gil, Alberto</au><au>Villanueva Fernández, Héctor</au><au>Hernández-Pérez, Francisco José</au><au>Campo-Cañaveral de la Cruz, José Luis</au><au>Velasco Calvo, Rocío</au><au>Segovia-Cubero, Javier</au><au>Alonso Menárguez, Beatriz</au><au>Del Río Gallegos, Francisco</au><au>Coll, Elisabeth</au><au>Domínguez-Gil González, Beatriz</au><au>Rubio Muñoz, Juan José</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transplantation of a heart donated after circulatory death via thoraco-abdominal normothermic regional perfusion and results from the first Spanish case</atitle><jtitle>Journal of cardiothoracic surgery</jtitle><addtitle>J Cardiothorac Surg</addtitle><date>2020-11-25</date><risdate>2020</risdate><volume>15</volume><issue>1</issue><spage>333</spage><epage>333</epage><pages>333-333</pages><artnum>333</artnum><issn>1749-8090</issn><eissn>1749-8090</eissn><abstract>Controlled donation after circulatory death (cDCD) has emerged as one of the main strategies for increasing the organ donor pool. Because of the ischemic injury that follows the withdrawal of life-sustaining therapies, hearts from cDCD donors have not been considered for transplantation until recently. The ex-situ perfusion of hearts directly procured from cDCD donors has been used to allow the continuous perfusion of the organ and the assessment of myocardial viability prior to transplantation. Based on our experience with abdominal normothermic regional perfusion in cDCD, we designed a protocol to recover and validate hearts from cDCD donors using thoraco-abdominal normothermic regional perfusion without the utilization of an ex-situ device.
We describe the first case of a cDCD heart transplant performed with this approach in Spain. The donor was a 43-year-old asthmatic female diagnosed with severe hypoxic encephalopathy. She was considered a potential cDCD donor and a suitable candidate for multiorgan procurement including the heart via thoraco-abdominal normothermic regional perfusion. The heart recipient was a 60-year-old male diagnosed with amyloid cardiomyopathy. Cold ischemia time was 55 min. The surgery was uneventful.
This case report, the first of its kind in Spain, supports the feasibility of evaluating and successfully transplanting cDCD hearts without the need for ex-situ perfusion based on the use of thoraco-abdominal normothermic regional perfusion opening the way for multiorgan donation in cDCD.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>33239086</pmid><doi>10.1186/s13019-020-01372-z</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-4606-3416</orcidid><orcidid>https://orcid.org/0000-0003-0847-0392</orcidid><orcidid>https://orcid.org/0000-0001-7325-8473</orcidid><orcidid>https://orcid.org/0000-0002-2889-4312</orcidid><orcidid>https://orcid.org/0000-0002-5695-8993</orcidid><orcidid>https://orcid.org/0000-0001-6811-132X</orcidid><orcidid>https://orcid.org/0000-0001-6343-8112</orcidid><orcidid>https://orcid.org/0000-0002-3941-5743</orcidid><orcidid>https://orcid.org/0000-0003-3496-875X</orcidid><orcidid>https://orcid.org/0000-0003-0338-9253</orcidid><orcidid>https://orcid.org/0000-0001-9221-2307</orcidid><orcidid>https://orcid.org/0000-0001-7572-4685</orcidid><orcidid>https://orcid.org/0000-0002-8591-0120</orcidid><orcidid>https://orcid.org/0000-0001-6876-7476</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1749-8090 |
| ispartof | Journal of cardiothoracic surgery, 2020-11, Vol.15 (1), p.333-333, Article 333 |
| issn | 1749-8090 1749-8090 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7687983 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; SpringerLink Journals; PubMed Central Open Access; Springer Nature OA Free Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Abdomen Adult Amyloid Anesthesia Asthma Blood & organ donations Cardiomyopathy Case Report Catheters Death Encephalopathy Extracorporeal Membrane Oxygenation Female Heart Heart Transplantation Hospitals Humans Hypoxia Intensive care Ischemia Kidneys Liver Male Middle Aged Organ donors Perfusion Perfusion - methods Spain Surgery Thoracic surgery Thorax Tissue and Organ Harvesting - methods Tissue Donors Transplantation Transplants & implants Ultrasonic imaging Veins & arteries |
| title | Transplantation of a heart donated after circulatory death via thoraco-abdominal normothermic regional perfusion and results from the first Spanish case |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T05%3A57%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Transplantation%20of%20a%20heart%20donated%20after%20circulatory%20death%20via%20thoraco-abdominal%20normothermic%20regional%20perfusion%20and%20results%20from%20the%20first%20Spanish%20case&rft.jtitle=Journal%20of%20cardiothoracic%20surgery&rft.au=P%C3%A9rez%20Redondo,%20Marina&rft.date=2020-11-25&rft.volume=15&rft.issue=1&rft.spage=333&rft.epage=333&rft.pages=333-333&rft.artnum=333&rft.issn=1749-8090&rft.eissn=1749-8090&rft_id=info:doi/10.1186/s13019-020-01372-z&rft_dat=%3Cgale_pubme%3EA650661703%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2471127736&rft_id=info:pmid/33239086&rft_galeid=A650661703&rfr_iscdi=true |