Cortical Observation by Synchronous Multifocal Optical Sampling Reveals Widespread Population Encoding of Actions

To advance the measurement of distributed neuronal population representations of targeted motor actions on single trials, we developed an optical method (COSMOS) for tracking neural activity in a largely uncharacterized spatiotemporal regime. COSMOS allowed simultaneous recording of neural dynamics...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2020-07, Vol.107 (2), p.351-367.e19
Hauptverfasser:	Kauvar, Isaac V., Machado, Timothy A., Yuen, Elle, Kochalka, John, Choi, Minseung, Allen, William E., Wetzstein, Gordon, Deisseroth, Karl
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Animals Behavior, Animal - physiology Brain Mapping calcium imaging Cerebral Cortex - physiology Conditioning, Operant cortex COSMOS Craniotomy licking Mice motor planning multifocal Neocortex Neocortex - cytology Neocortex - physiology neural decoding neural dynamics Neuroimaging - instrumentation Neuroimaging - methods Neurons Observation - methods Optics Optogenetics - methods Population Population dynamics Psychomotor Performance Robotic Surgical Procedures - instrumentation Robotic Surgical Procedures - methods Signal-To-Noise Ratio synchronous widefield
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