Curcumin alleviates oxidative stress and inhibits apoptosis in diabetic cardiomyopathy via Sirt1‐Foxo1 and PI3K‐Akt signalling pathways

Diabetes is a disorder of glucose metabolism, and over 90% are type 2 diabetes. Diabetic cardiomyopathy (DCM) is one of the type 2 diabetes complications, usually accompanied by changes in myocardial structure and function, together with cardiomyocyte apoptosis. Our study investigated the effect of...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2020-11, Vol.24 (21), p.12355-12367
Hauptverfasser:	Ren, Bin‐cheng, Zhang, Yu‐fei, Liu, Shan‐shan, Cheng, Xiao‐jing, Yang, Xin, Cui, Xiao‐guang, Zhao, Xin‐rui, Zhao, Hui, Hao, Min‐feng, Li, Meng‐dan, Tie, Yuan‐yuan, Qu, Li, Li, Xue‐yi
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Acetylation AKT protein Antibodies Apoptosis Cardiac function Cardiomyocytes Cardiomyopathy Caspase Curcumin Diabetes Diabetes mellitus (non-insulin dependent) Experiments FOXO1 protein Glucose Glucose metabolism High fat diet Kinases Laboratory animals Malondialdehyde Metabolism Original Oxidative stress Palmitic acid Phosphorylation PI3K‐Akt Proteins Signal transduction Sirt1 SIRT1 protein Structure-function relationships Superoxide dismutase type 2 diabetes
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