Inhibitory effect of Ubenimex combined with fluorouracil on multiple drug resistance and P‐glycoprotein expression level in non‐small lung cancer

Tumour drug resistance is one of the most urgent issues faced by anti‐tumour therapies. P‐glycoprotein (P‐gp) has been reported to be correlated with drug resistance. In this study, we aimed to study the synergistic effect of fluorouracil (5FU) and Ubenimex (UBE) on drug resistance in lung cancer. I...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2020-11, Vol.24 (21), p.12840-12847
Hauptverfasser:	Wan, Jun, Ling, Xie‐an, Wang, Jian, Ding, Guang‐gui, Wang, Xi
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Fluorouracil 5FU A549 Cells Animals Antibodies Apoptosis Apoptosis - drug effects ATP Binding Cassette Transporter, Subfamily B, Member 1 - genetics ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism Cancer therapies Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - pathology Cell Survival - drug effects Chemotherapy Doxorubicin - pharmacology Doxorubicin - therapeutic use Drug resistance Drug Resistance, Multiple - drug effects Drug Resistance, Neoplasm - drug effects Fluorouracil - administration & dosage Fluorouracil - pharmacology Fluorouracil - therapeutic use Gene expression Gene Expression Regulation, Neoplastic - drug effects Glycoproteins Humans Leucine - administration & dosage Leucine - analogs & derivatives Leucine - pharmacology Leucine - therapeutic use Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - pathology Metastasis Mice, Inbred C57BL Mice, Nude mRNA Multidrug resistance multiple drug resistance Original Penicillin Polymerase chain reaction Proteins P‐gp RNA, Messenger - genetics RNA, Messenger - metabolism Tumors Ubenimex
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