Mesenchymal stem cell–secreted extracellular vesicles carrying TGF‐β1 up‐regulate miR‐132 and promote mouse M2 macrophage polarization

The effects of mesenchymal stem cells (MSCs) on different types of diseases are controversial, and the inner mechanisms remain unknown, which retards the utilization of MSCs in disease therapy. In this study, we aimed to elucidate the mechanisms of MSCs‐extracellular vesicles (EVs) carrying transfor...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2020-11, Vol.24 (21), p.12750-12764
Hauptverfasser:	Wang, Yongqi, Han, Biao, Wang, Yingbin, Wang, Chunai, Zhang, Hong, Xue, Jianjun, Wang, Xiaoqing, Niu, Tingting, Niu, Zhen, Chen, Yuhe
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Base Sequence Bone marrow Cell culture Cell Polarity - genetics Cell Separation Down-Regulation - genetics Enzyme-linked immunosorbent assay Extracellular vesicles Extracellular Vesicles - metabolism Flow cytometry Gene expression HEK293 Cells Humans Lipopolysaccharides M2 polarization Macrophages Macrophages - cytology Macrophages - metabolism Mesenchymal stem cells Mesenchymal Stem Cells - metabolism Mice Mice, Inbred C57BL MicroRNAs - genetics MicroRNAs - metabolism microRNA‐132 miRNA Models, Biological Myc protein Mycbp2 Original Phenotype Polarization Proteins Proteolysis RAW 264.7 Cells Stem cell transplantation Stem cells TGF‐β1 Transforming Growth Factor beta1 - metabolism Transforming growth factor-b1 TSC2 Tuberous sclerosis Tuberous Sclerosis Complex 2 Tuberous Sclerosis Complex 2 Protein - metabolism Tumor necrosis factor Tumor necrosis factor-TNF Tumors Ubiquitin Ubiquitin-protein ligase Ubiquitin-Protein Ligases - metabolism Ubiquitination Up-Regulation - genetics
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