Corticosteroids alleviate lipopolysaccharide‐induced inflammation and lung injury via inhibiting NLRP3‐inflammasome activation

The role of corticosteroids in acute lung injury (ALI) remains uncertain. This study aims to determine the underlying mechanisms of corticosteroid treatment for lipopolysaccharide (LPS)‐induced inflammation and ALI. We used corticosteroid treatment for LPS‐induced murine ALI model to investigate the...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2020-11, Vol.24 (21), p.12716-12725
Hauptverfasser:	Yang, Jia‐Wei, Mao, Bei, Tao, Ru‐Jia, Fan, Li‐Chao, Lu, Hai‐Wen, Ge, Bao‐Xue, Xu, Jin‐Fu
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Lung Injury Adrenal Cortex Hormones - pharmacology Adrenal Cortex Hormones - therapeutic use Alveoli Animals Caspase Caspase 1 - metabolism Corticosteroids Cytokines Dexamethasone - pharmacology Dexamethasone - therapeutic use Enzyme Activation - drug effects Experiments Flow cytometry Inflammasomes Inflammasomes - antagonists & inhibitors Inflammasomes - metabolism Inflammation Inflammation - chemically induced Inflammation - drug therapy Inflammation - metabolism Interleukin-18 - metabolism Leukocytes (neutrophilic) Lipopolysaccharides Lungs Macrophages Mice, Inbred C57BL Microscopy Mitochondria Mitochondria - drug effects Mitochondria - metabolism mitochondrial reactive oxygen species Models, Biological Neutrophils NF-kappa B - metabolism NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors NLR Family, Pyrin Domain-Containing 3 Protein - metabolism NLRP3‐inflammasome Original Pathogens Proteins Reactive oxygen species Reactive Oxygen Species - metabolism Signal Transduction Software
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