OXPHOS-dependent metabolic reprogramming prompts metastatic potential of breast cancer cells under osteogenic differentiation

Background Microcalcification is one of the most reliable clinical features of the malignancy risk of breast cancer, and it is associated with enhanced tumour aggressiveness and poor prognosis. However, its underlying molecular mechanism remains unclear. Methods Clinical data were retrieved to analy...

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Veröffentlicht in:	British journal of cancer 2020-11, Vol.123 (11), p.1644-1655
Hauptverfasser:	Hu, Yangling, Xu, Weimin, Zeng, Hui, He, Zilong, Lu, Xiao, Zuo, Daming, Qin, Genggeng, Chen, Weiguo
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1347 631/67/2327 631/67/322 Biomedical and Life Sciences Biomedicine Bone cancer Breast cancer Breast Neoplasms - pathology Calcification Calcinosis - metabolism Cancer Research Cell Differentiation Cellular Reprogramming - physiology Drug Resistance Epidemiology Epithelial-Mesenchymal Transition - physiology Female Gene expression Glands Humans Malignancy MAP kinase Mesenchyme Metabolism Metastases Metastasis Mitochondria Molecular Medicine mRNA Neoplasm Invasiveness - pathology Oncology Osteogenesis Osteogenesis - physiology Oxidative Phosphorylation Phenotypes Phosphorylation Rotenone Secretions Signal transduction Smad protein Tumor cell lines Tumors Western blotting Wound healing
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