Overcoming the blood–brain barrier by Annexin A1-binding peptide to target brain tumours

Background Annexin A1 is expressed specifically on the tumour vasculature surface. Intravenously injected IF7 targets tumour vasculature via annexin A1. We tested the hypothesis that IF7 overcomes the blood–brain barrier and that the intravenously injected IF7C(RR)-SN38 eradicates brain tumours in t...

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Veröffentlicht in:	British journal of cancer 2020-11, Vol.123 (11), p.1633-1643
Hauptverfasser:	Nonaka, Motohiro, Suzuki-Anekoji, Misa, Nakayama, Jun, Mabashi-Asazuma, Hideaki, Jarvis, Donald L., Yeh, Jiunn-Chern, Yamasaki, Kazuhiko, Akama, Tomoya O., Huang, Chun-Teng, Campos, Alexandre Rosa, Nagaoka, Masato, Sasai, Toshio, Kimura-Takagi, Itsuko, Suwa, Yoichi, Yaegashi, Takashi, Shibata, Toshiaki K., Sugihara, Kazuhiro, Nishizawa-Harada, Chizuko, Fukuda, Minoru, Fukuda, Michiko N.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1922 692/699/67/1059 Animal models Animals Annexin A1 - metabolism Antineoplastic Agents - pharmacology Biomedical and Life Sciences Biomedicine Blood-brain barrier Blood-Brain Barrier - metabolism Brain cancer Brain Neoplasms Brain tumors Cancer Research Cell culture Chemiluminescence Drug Carriers - pharmacology Drug Resistance Epidemiology Humans Immune response Injection Melanoma Mice Mice, Inbred C57BL Mice, SCID Molecular Medicine Oncology Peptides Rats Tumor cell lines Tumors
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