Painful and non-painful chemotherapy-induced peripheral neuropathy and quality of life in colorectal cancer survivors: results from the population-based PROFILES registry
Purpose This study aims to (1) examine the prevalence of painful versus non-painful chemotherapy-induced peripheral neuropathy (CIPN) among long-term colorectal cancer (CRC) survivors, (2) identify sociodemographic, clinical, and psychological factors associated with painful and non-painful CIPN, an...
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| Veröffentlicht in: | Supportive care in cancer 2020-12, Vol.28 (12), p.5933-5941 |
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| creator | Bonhof, C. S. Trompetter, H. R. Vreugdenhil, G. van de Poll-Franse, L. V. Mols, F. |
| description | Purpose
This study aims to (1) examine the prevalence of painful versus non-painful chemotherapy-induced peripheral neuropathy (CIPN) among long-term colorectal cancer (CRC) survivors, (2) identify sociodemographic, clinical, and psychological factors associated with painful and non-painful CIPN, and (3) examine the associations of painful CIPN with health-related quality of life (HRQoL) in comparison with non-painful CIPN, i.e., numbness/tingling.
Methods
All CRC survivors diagnosed between 2000 and 2009 as registered by the population-based Netherlands Cancer Registry (Eindhoven region) were eligible for participation. Chemotherapy-treated survivors (
n
= 477) completed questions on CIPN (EORTC QLQ-CIPN20) and HRQoL (EORTC QLQ-C30).
Results
Painful CIPN was reported by 9% (
n
= 45) of survivors and non-painful CIPN was reported by 22% (
n
= 103). Time since diagnosis was related to painful CIPN, and time since diagnosis, a higher disease stage, osteoarthritis, and more anxiety symptoms were related to non-painful CIPN. Finally, survivors with painful CIPN reported a worse global quality of life and worse physical, role, cognitive, and social functioning compared to survivors with non-painful CIPN and those without any sensory CIPN. No differences were found between survivors with non-painful CIPN and those without sensory CIPN.
Conclusions
It seems that painful CIPN must be distinguished from non-painful CIPN, as only painful CIPN was related to a worse HRQoL. Future research is needed to examine whether painful CIPN must be distinguished from non-painful CIPN regarding predictors, mechanisms, and treatment. |
| doi_str_mv | 10.1007/s00520-020-05438-5 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7686173</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A650995389</galeid><sourcerecordid>A650995389</sourcerecordid><originalsourceid>FETCH-LOGICAL-c607t-a4f5a49f41688fa2b61e22745fc9fbc6abc471fc0ae430df09fe8bebb31a5f5d3</originalsourceid><addsrcrecordid>eNp9Uttq3DAQFaWl2W77A30ogj47kSzJlz4UQkjawEJCL89Clke7CrbkSPaCf6lfWbm7SRooRQxCM-ecmREHofeUnFJCyrNIiMhJRpYQnFWZeIFWlDOWlYzVL9GK1JxmnAlxgt7EeEcILUuRv0YnLM8rSli-Qr9ulXVm6rByLXbeZcPxrXfQ-3EHQQ1zZl07aWjxAMEOS67DDqbgBzXu5j_U-0l1dpyxN7izBrB1WPvOB9BjAmvlNAQcp7C3ex_iJxwgTt0YsQm-x6kNHvwwdWq0aYRGxdTr9tvN1fXm8nuCbm0cw_wWvTKqi_DueK_Rz6vLHxdfs83Nl-uL802mC1KOmeJGKF4bTouqMipvCgp5XnJhdG0aXahG85IaTRRwRlpDagNVA03DqBJGtGyNPh90h6npodXgxrSwHILtVZilV1Y-rzi7k1u_l2VRFTR9_Rp9PAoEfz9BHOWdn4JLM8ucp3olyoI_obaqA5k-3Scx3duo5XkhSF0LVtUJdfoPVDot9FZ7B8am_DNCfiDo4GMMYB4Hp0QutpEH20iyxGIbKRLpw98rP1IefJIA7ACIqeS2EJ5W-o_sb04e0qE</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2473385764</pqid></control><display><type>article</type><title>Painful and non-painful chemotherapy-induced peripheral neuropathy and quality of life in colorectal cancer survivors: results from the population-based PROFILES registry</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Bonhof, C. S. ; Trompetter, H. R. ; Vreugdenhil, G. ; van de Poll-Franse, L. V. ; Mols, F.</creator><creatorcontrib>Bonhof, C. S. ; Trompetter, H. R. ; Vreugdenhil, G. ; van de Poll-Franse, L. V. ; Mols, F.</creatorcontrib><description>Purpose
This study aims to (1) examine the prevalence of painful versus non-painful chemotherapy-induced peripheral neuropathy (CIPN) among long-term colorectal cancer (CRC) survivors, (2) identify sociodemographic, clinical, and psychological factors associated with painful and non-painful CIPN, and (3) examine the associations of painful CIPN with health-related quality of life (HRQoL) in comparison with non-painful CIPN, i.e., numbness/tingling.
Methods
All CRC survivors diagnosed between 2000 and 2009 as registered by the population-based Netherlands Cancer Registry (Eindhoven region) were eligible for participation. Chemotherapy-treated survivors (
n
= 477) completed questions on CIPN (EORTC QLQ-CIPN20) and HRQoL (EORTC QLQ-C30).
Results
Painful CIPN was reported by 9% (
n
= 45) of survivors and non-painful CIPN was reported by 22% (
n
= 103). Time since diagnosis was related to painful CIPN, and time since diagnosis, a higher disease stage, osteoarthritis, and more anxiety symptoms were related to non-painful CIPN. Finally, survivors with painful CIPN reported a worse global quality of life and worse physical, role, cognitive, and social functioning compared to survivors with non-painful CIPN and those without any sensory CIPN. No differences were found between survivors with non-painful CIPN and those without sensory CIPN.
Conclusions
It seems that painful CIPN must be distinguished from non-painful CIPN, as only painful CIPN was related to a worse HRQoL. Future research is needed to examine whether painful CIPN must be distinguished from non-painful CIPN regarding predictors, mechanisms, and treatment.</description><identifier>ISSN: 0941-4355</identifier><identifier>EISSN: 1433-7339</identifier><identifier>DOI: 10.1007/s00520-020-05438-5</identifier><identifier>PMID: 32281032</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aged ; Antineoplastic Agents - adverse effects ; Antineoplastic Agents - therapeutic use ; Anxiety - psychology ; Cancer Survivors - psychology ; Chemotherapy ; Colonic Neoplasms - drug therapy ; Colonic Neoplasms - psychology ; Colorectal cancer ; Female ; Humans ; Hypesthesia - chemically induced ; Hypesthesia - psychology ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Netherlands - epidemiology ; Nursing ; Nursing Research ; Oncology ; Original ; Original Article ; Osteoarthritis ; Pain ; Pain - drug therapy ; Pain - psychology ; Pain Medicine ; Paresthesia - chemically induced ; Paresthesia - psychology ; Peripheral Nervous System Diseases - chemically induced ; Peripheral Nervous System Diseases - epidemiology ; Peripheral Nervous System Diseases - psychology ; Peripheral neuropathy ; Quality of life ; Quality of Life - psychology ; Registries ; Rehabilitation Medicine ; Surveys and Questionnaires ; Survivor</subject><ispartof>Supportive care in cancer, 2020-12, Vol.28 (12), p.5933-5941</ispartof><rights>The Author(s) 2020</rights><rights>COPYRIGHT 2020 Springer</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c607t-a4f5a49f41688fa2b61e22745fc9fbc6abc471fc0ae430df09fe8bebb31a5f5d3</citedby><cites>FETCH-LOGICAL-c607t-a4f5a49f41688fa2b61e22745fc9fbc6abc471fc0ae430df09fe8bebb31a5f5d3</cites><orcidid>0000-0003-0413-6872 ; 0000-0002-8816-1540 ; 0000-0003-0818-2913 ; 0000-0002-7365-5353 ; 0000-0003-4518-6999</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00520-020-05438-5$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00520-020-05438-5$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32281032$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bonhof, C. S.</creatorcontrib><creatorcontrib>Trompetter, H. R.</creatorcontrib><creatorcontrib>Vreugdenhil, G.</creatorcontrib><creatorcontrib>van de Poll-Franse, L. V.</creatorcontrib><creatorcontrib>Mols, F.</creatorcontrib><title>Painful and non-painful chemotherapy-induced peripheral neuropathy and quality of life in colorectal cancer survivors: results from the population-based PROFILES registry</title><title>Supportive care in cancer</title><addtitle>Support Care Cancer</addtitle><addtitle>Support Care Cancer</addtitle><description>Purpose
This study aims to (1) examine the prevalence of painful versus non-painful chemotherapy-induced peripheral neuropathy (CIPN) among long-term colorectal cancer (CRC) survivors, (2) identify sociodemographic, clinical, and psychological factors associated with painful and non-painful CIPN, and (3) examine the associations of painful CIPN with health-related quality of life (HRQoL) in comparison with non-painful CIPN, i.e., numbness/tingling.
Methods
All CRC survivors diagnosed between 2000 and 2009 as registered by the population-based Netherlands Cancer Registry (Eindhoven region) were eligible for participation. Chemotherapy-treated survivors (
n
= 477) completed questions on CIPN (EORTC QLQ-CIPN20) and HRQoL (EORTC QLQ-C30).
Results
Painful CIPN was reported by 9% (
n
= 45) of survivors and non-painful CIPN was reported by 22% (
n
= 103). Time since diagnosis was related to painful CIPN, and time since diagnosis, a higher disease stage, osteoarthritis, and more anxiety symptoms were related to non-painful CIPN. Finally, survivors with painful CIPN reported a worse global quality of life and worse physical, role, cognitive, and social functioning compared to survivors with non-painful CIPN and those without any sensory CIPN. No differences were found between survivors with non-painful CIPN and those without sensory CIPN.
Conclusions
It seems that painful CIPN must be distinguished from non-painful CIPN, as only painful CIPN was related to a worse HRQoL. Future research is needed to examine whether painful CIPN must be distinguished from non-painful CIPN regarding predictors, mechanisms, and treatment.</description><subject>Aged</subject><subject>Antineoplastic Agents - adverse effects</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Anxiety - psychology</subject><subject>Cancer Survivors - psychology</subject><subject>Chemotherapy</subject><subject>Colonic Neoplasms - drug therapy</subject><subject>Colonic Neoplasms - psychology</subject><subject>Colorectal cancer</subject><subject>Female</subject><subject>Humans</subject><subject>Hypesthesia - chemically induced</subject><subject>Hypesthesia - psychology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Netherlands - epidemiology</subject><subject>Nursing</subject><subject>Nursing Research</subject><subject>Oncology</subject><subject>Original</subject><subject>Original Article</subject><subject>Osteoarthritis</subject><subject>Pain</subject><subject>Pain - drug therapy</subject><subject>Pain - psychology</subject><subject>Pain Medicine</subject><subject>Paresthesia - chemically induced</subject><subject>Paresthesia - psychology</subject><subject>Peripheral Nervous System Diseases - chemically induced</subject><subject>Peripheral Nervous System Diseases - epidemiology</subject><subject>Peripheral Nervous System Diseases - psychology</subject><subject>Peripheral neuropathy</subject><subject>Quality of life</subject><subject>Quality of Life - psychology</subject><subject>Registries</subject><subject>Rehabilitation Medicine</subject><subject>Surveys and Questionnaires</subject><subject>Survivor</subject><issn>0941-4355</issn><issn>1433-7339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9Uttq3DAQFaWl2W77A30ogj47kSzJlz4UQkjawEJCL89Clke7CrbkSPaCf6lfWbm7SRooRQxCM-ecmREHofeUnFJCyrNIiMhJRpYQnFWZeIFWlDOWlYzVL9GK1JxmnAlxgt7EeEcILUuRv0YnLM8rSli-Qr9ulXVm6rByLXbeZcPxrXfQ-3EHQQ1zZl07aWjxAMEOS67DDqbgBzXu5j_U-0l1dpyxN7izBrB1WPvOB9BjAmvlNAQcp7C3ex_iJxwgTt0YsQm-x6kNHvwwdWq0aYRGxdTr9tvN1fXm8nuCbm0cw_wWvTKqi_DueK_Rz6vLHxdfs83Nl-uL802mC1KOmeJGKF4bTouqMipvCgp5XnJhdG0aXahG85IaTRRwRlpDagNVA03DqBJGtGyNPh90h6npodXgxrSwHILtVZilV1Y-rzi7k1u_l2VRFTR9_Rp9PAoEfz9BHOWdn4JLM8ucp3olyoI_obaqA5k-3Scx3duo5XkhSF0LVtUJdfoPVDot9FZ7B8am_DNCfiDo4GMMYB4Hp0QutpEH20iyxGIbKRLpw98rP1IefJIA7ACIqeS2EJ5W-o_sb04e0qE</recordid><startdate>20201201</startdate><enddate>20201201</enddate><creator>Bonhof, C. S.</creator><creator>Trompetter, H. R.</creator><creator>Vreugdenhil, G.</creator><creator>van de Poll-Franse, L. V.</creator><creator>Mols, F.</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88J</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HEHIP</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2R</scope><scope>M2S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0413-6872</orcidid><orcidid>https://orcid.org/0000-0002-8816-1540</orcidid><orcidid>https://orcid.org/0000-0003-0818-2913</orcidid><orcidid>https://orcid.org/0000-0002-7365-5353</orcidid><orcidid>https://orcid.org/0000-0003-4518-6999</orcidid></search><sort><creationdate>20201201</creationdate><title>Painful and non-painful chemotherapy-induced peripheral neuropathy and quality of life in colorectal cancer survivors: results from the population-based PROFILES registry</title><author>Bonhof, C. S. ; Trompetter, H. R. ; Vreugdenhil, G. ; van de Poll-Franse, L. 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S.</creatorcontrib><creatorcontrib>Trompetter, H. R.</creatorcontrib><creatorcontrib>Vreugdenhil, G.</creatorcontrib><creatorcontrib>van de Poll-Franse, L. V.</creatorcontrib><creatorcontrib>Mols, F.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Sociology Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Social Science Database</collection><collection>Sociology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Supportive care in cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bonhof, C. S.</au><au>Trompetter, H. R.</au><au>Vreugdenhil, G.</au><au>van de Poll-Franse, L. V.</au><au>Mols, F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Painful and non-painful chemotherapy-induced peripheral neuropathy and quality of life in colorectal cancer survivors: results from the population-based PROFILES registry</atitle><jtitle>Supportive care in cancer</jtitle><stitle>Support Care Cancer</stitle><addtitle>Support Care Cancer</addtitle><date>2020-12-01</date><risdate>2020</risdate><volume>28</volume><issue>12</issue><spage>5933</spage><epage>5941</epage><pages>5933-5941</pages><issn>0941-4355</issn><eissn>1433-7339</eissn><abstract>Purpose
This study aims to (1) examine the prevalence of painful versus non-painful chemotherapy-induced peripheral neuropathy (CIPN) among long-term colorectal cancer (CRC) survivors, (2) identify sociodemographic, clinical, and psychological factors associated with painful and non-painful CIPN, and (3) examine the associations of painful CIPN with health-related quality of life (HRQoL) in comparison with non-painful CIPN, i.e., numbness/tingling.
Methods
All CRC survivors diagnosed between 2000 and 2009 as registered by the population-based Netherlands Cancer Registry (Eindhoven region) were eligible for participation. Chemotherapy-treated survivors (
n
= 477) completed questions on CIPN (EORTC QLQ-CIPN20) and HRQoL (EORTC QLQ-C30).
Results
Painful CIPN was reported by 9% (
n
= 45) of survivors and non-painful CIPN was reported by 22% (
n
= 103). Time since diagnosis was related to painful CIPN, and time since diagnosis, a higher disease stage, osteoarthritis, and more anxiety symptoms were related to non-painful CIPN. Finally, survivors with painful CIPN reported a worse global quality of life and worse physical, role, cognitive, and social functioning compared to survivors with non-painful CIPN and those without any sensory CIPN. No differences were found between survivors with non-painful CIPN and those without sensory CIPN.
Conclusions
It seems that painful CIPN must be distinguished from non-painful CIPN, as only painful CIPN was related to a worse HRQoL. Future research is needed to examine whether painful CIPN must be distinguished from non-painful CIPN regarding predictors, mechanisms, and treatment.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>32281032</pmid><doi>10.1007/s00520-020-05438-5</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-0413-6872</orcidid><orcidid>https://orcid.org/0000-0002-8816-1540</orcidid><orcidid>https://orcid.org/0000-0003-0818-2913</orcidid><orcidid>https://orcid.org/0000-0002-7365-5353</orcidid><orcidid>https://orcid.org/0000-0003-4518-6999</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Supportive care in cancer, 2020-12, Vol.28 (12), p.5933-5941 |
| issn | 0941-4355 1433-7339 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Aged Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Anxiety - psychology Cancer Survivors - psychology Chemotherapy Colonic Neoplasms - drug therapy Colonic Neoplasms - psychology Colorectal cancer Female Humans Hypesthesia - chemically induced Hypesthesia - psychology Male Medicine Medicine & Public Health Middle Aged Netherlands - epidemiology Nursing Nursing Research Oncology Original Original Article Osteoarthritis Pain Pain - drug therapy Pain - psychology Pain Medicine Paresthesia - chemically induced Paresthesia - psychology Peripheral Nervous System Diseases - chemically induced Peripheral Nervous System Diseases - epidemiology Peripheral Nervous System Diseases - psychology Peripheral neuropathy Quality of life Quality of Life - psychology Registries Rehabilitation Medicine Surveys and Questionnaires Survivor |
| title | Painful and non-painful chemotherapy-induced peripheral neuropathy and quality of life in colorectal cancer survivors: results from the population-based PROFILES registry |
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