Association of meibomian gland morphology with symptoms and signs of dry eye disease in the Dry Eye Assessment and Management (DREAM) study
To describe associations between symptoms and signs of dry eye disease (DED) and meibomian gland (MG) morphology. Cross-sectional study utilizing data from the Dry Eye Assessment and Management (DREAM) Study. Readers graded MG features in the middle third of upper and lower lids on infrared meibogra...
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| Veröffentlicht in: | The ocular surface 2020-10, Vol.18 (4), p.761-769 |
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| creator | Daniel, Ebenezer Pistilli, Maxwell Ying, Gui-shuang Bunya, Vatinee Y. Massaro-Giordano, Mina Asbell, Penny A. Maguire, Maureen G. |
| description | To describe associations between symptoms and signs of dry eye disease (DED) and meibomian gland (MG) morphology.
Cross-sectional study utilizing data from the Dry Eye Assessment and Management (DREAM) Study. Readers graded MG features in the middle third of upper and lower lids on infrared meibography images. Associations with signs and symptoms of DED were evaluated with adjustment for age and sex.
Among 268 patients, no MG features were associated with symptom scores (p > 0.08). Among 394 upper eyelids, better tear break-up times (2- 5–10, and >10 mm) were associated with increasing composite scores (22.02 (9.29), 23.80 (10.34), 24.96 (9.96), p = 0.03). Patients with Sjogren syndrome compared to other patients had fewer distorted MGs (mean 3.4 (2.3) vs 4.3 (2.3), p = 0.03) and fewer ghost glands (mean 0.33 (0.88) vs 0.89 (1.8), p = 0.006) in the upper lid.
In the DREAM study, most MG morphologic features were not associated with the severity of DED symptoms or signs. Tortuous glands and a higher composite score for MG features were associated with longer tear break-up times and longer Schirmer test length in the upper eyelid only. Patients with Sjogren syndrome had fewer distorted and ghost glands. |
| doi_str_mv | 10.1016/j.jtos.2020.07.014 |
| format | Article |
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Cross-sectional study utilizing data from the Dry Eye Assessment and Management (DREAM) Study. Readers graded MG features in the middle third of upper and lower lids on infrared meibography images. Associations with signs and symptoms of DED were evaluated with adjustment for age and sex.
Among 268 patients, no MG features were associated with symptom scores (p > 0.08). Among 394 upper eyelids, better tear break-up times (<2, >2- <3.2and ≥ 3.2 s) were associated with more tortuous glands (mean (SD) 0.58(0.95), 0.83(1.2) and 1.14 (1.4), p = 0.01) and with higher scores on a composite score of MG features (21.90 (9.76), 23.29 (9.50), 26.26 (10.27); p = 0.02). Longer Schirmer test wetting lengths (0–5, >5–10, and >10 mm) were associated with increasing composite scores (22.02 (9.29), 23.80 (10.34), 24.96 (9.96), p = 0.03). Patients with Sjogren syndrome compared to other patients had fewer distorted MGs (mean 3.4 (2.3) vs 4.3 (2.3), p = 0.03) and fewer ghost glands (mean 0.33 (0.88) vs 0.89 (1.8), p = 0.006) in the upper lid.
In the DREAM study, most MG morphologic features were not associated with the severity of DED symptoms or signs. Tortuous glands and a higher composite score for MG features were associated with longer tear break-up times and longer Schirmer test length in the upper eyelid only. Patients with Sjogren syndrome had fewer distorted and ghost glands.</description><identifier>ISSN: 1542-0124</identifier><identifier>EISSN: 1937-5913</identifier><identifier>DOI: 10.1016/j.jtos.2020.07.014</identifier><identifier>PMID: 32858234</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cross-Sectional Studies ; Dry eye disease ; Dry Eye Syndromes - diagnosis ; Female ; Humans ; Male ; Meibography ; Meibomian Glands - diagnostic imaging ; Middle Aged ; Ocular surface disease index ; Sjogren's Syndrome ; Tear function tests ; Tears ; Young Adult</subject><ispartof>The ocular surface, 2020-10, Vol.18 (4), p.761-769</ispartof><rights>2020</rights><rights>Copyright © 2020. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-3196d24ff1eb5639de9039dbf5f8bf3581b8458c8a0748472d653610165ff3363</citedby><cites>FETCH-LOGICAL-c455t-3196d24ff1eb5639de9039dbf5f8bf3581b8458c8a0748472d653610165ff3363</cites><orcidid>0000-0002-2027-2316</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32858234$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Daniel, Ebenezer</creatorcontrib><creatorcontrib>Pistilli, Maxwell</creatorcontrib><creatorcontrib>Ying, Gui-shuang</creatorcontrib><creatorcontrib>Bunya, Vatinee Y.</creatorcontrib><creatorcontrib>Massaro-Giordano, Mina</creatorcontrib><creatorcontrib>Asbell, Penny A.</creatorcontrib><creatorcontrib>Maguire, Maureen G.</creatorcontrib><creatorcontrib>for the Dry Eye Assessment and Management (DREAM) Study Research Group</creatorcontrib><creatorcontrib>Dry Eye Assessment and Management (DREAM) Study Research Group</creatorcontrib><title>Association of meibomian gland morphology with symptoms and signs of dry eye disease in the Dry Eye Assessment and Management (DREAM) study</title><title>The ocular surface</title><addtitle>Ocul Surf</addtitle><description>To describe associations between symptoms and signs of dry eye disease (DED) and meibomian gland (MG) morphology.
Cross-sectional study utilizing data from the Dry Eye Assessment and Management (DREAM) Study. Readers graded MG features in the middle third of upper and lower lids on infrared meibography images. Associations with signs and symptoms of DED were evaluated with adjustment for age and sex.
Among 268 patients, no MG features were associated with symptom scores (p > 0.08). Among 394 upper eyelids, better tear break-up times (<2, >2- <3.2and ≥ 3.2 s) were associated with more tortuous glands (mean (SD) 0.58(0.95), 0.83(1.2) and 1.14 (1.4), p = 0.01) and with higher scores on a composite score of MG features (21.90 (9.76), 23.29 (9.50), 26.26 (10.27); p = 0.02). Longer Schirmer test wetting lengths (0–5, >5–10, and >10 mm) were associated with increasing composite scores (22.02 (9.29), 23.80 (10.34), 24.96 (9.96), p = 0.03). Patients with Sjogren syndrome compared to other patients had fewer distorted MGs (mean 3.4 (2.3) vs 4.3 (2.3), p = 0.03) and fewer ghost glands (mean 0.33 (0.88) vs 0.89 (1.8), p = 0.006) in the upper lid.
In the DREAM study, most MG morphologic features were not associated with the severity of DED symptoms or signs. Tortuous glands and a higher composite score for MG features were associated with longer tear break-up times and longer Schirmer test length in the upper eyelid only. Patients with Sjogren syndrome had fewer distorted and ghost glands.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cross-Sectional Studies</subject><subject>Dry eye disease</subject><subject>Dry Eye Syndromes - diagnosis</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Meibography</subject><subject>Meibomian Glands - diagnostic imaging</subject><subject>Middle Aged</subject><subject>Ocular surface disease index</subject><subject>Sjogren's Syndrome</subject><subject>Tear function tests</subject><subject>Tears</subject><subject>Young Adult</subject><issn>1542-0124</issn><issn>1937-5913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Uctu1EAQtBCIhMAPcEBzTA4287YtIaRVsglIiZAQnEdjT9s7q7Vncc8G-Rv4acbZEMGFyzy6q6pLXVn2ltGCUabfb4ttDFhwymlBy4Iy-Sw7ZbUoc1Uz8Ty9leQ5ZVyeZK8Qt5QKrSl_mZ0IXqmKC3ma_Vohhtbb6MNIQkcG8E0YvB1Jv7OjI0OY9puwC_1Mfvq4ITgP-xgGJEsTfT_iwnLTTGAG4jyCRSB-JHED5CqV16mcZgDiAGN8oN3Z0fbw8D2_-rpe3V0QjAc3v85edHaH8ObxPsu-X6-_XX7Kb7_cfL5c3eatVCrmgtXacdl1DBqlRe2gpulsOtVVTSdUxZpKqqqtLC1lJUvutBJ62ZjqOiG0OMs-HnX3h2YA1yYjk92Z_eQHO80mWG_-7Yx-Y_pwb0pdaaoWgfNHgSn8OABGM3hsYZc2BuGAhktR6ZozuUD5EdpOAXGC7mkMo2bxZLZmSdEsKRpampRiIr372-AT5U9sCfDhCIC0pnsPk8HWw9iC8xO00bjg_6f_GwLqsDk</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Daniel, Ebenezer</creator><creator>Pistilli, Maxwell</creator><creator>Ying, Gui-shuang</creator><creator>Bunya, Vatinee Y.</creator><creator>Massaro-Giordano, Mina</creator><creator>Asbell, Penny A.</creator><creator>Maguire, Maureen G.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2027-2316</orcidid></search><sort><creationdate>20201001</creationdate><title>Association of meibomian gland morphology with symptoms and signs of dry eye disease in the Dry Eye Assessment and Management (DREAM) study</title><author>Daniel, Ebenezer ; Pistilli, Maxwell ; Ying, Gui-shuang ; Bunya, Vatinee Y. ; Massaro-Giordano, Mina ; Asbell, Penny A. ; Maguire, Maureen G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-3196d24ff1eb5639de9039dbf5f8bf3581b8458c8a0748472d653610165ff3363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cross-Sectional Studies</topic><topic>Dry eye disease</topic><topic>Dry Eye Syndromes - diagnosis</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Meibography</topic><topic>Meibomian Glands - diagnostic imaging</topic><topic>Middle Aged</topic><topic>Ocular surface disease index</topic><topic>Sjogren's Syndrome</topic><topic>Tear function tests</topic><topic>Tears</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Daniel, Ebenezer</creatorcontrib><creatorcontrib>Pistilli, Maxwell</creatorcontrib><creatorcontrib>Ying, Gui-shuang</creatorcontrib><creatorcontrib>Bunya, Vatinee Y.</creatorcontrib><creatorcontrib>Massaro-Giordano, Mina</creatorcontrib><creatorcontrib>Asbell, Penny A.</creatorcontrib><creatorcontrib>Maguire, Maureen G.</creatorcontrib><creatorcontrib>for the Dry Eye Assessment and Management (DREAM) Study Research Group</creatorcontrib><creatorcontrib>Dry Eye Assessment and Management (DREAM) Study Research Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The ocular surface</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Daniel, Ebenezer</au><au>Pistilli, Maxwell</au><au>Ying, Gui-shuang</au><au>Bunya, Vatinee Y.</au><au>Massaro-Giordano, Mina</au><au>Asbell, Penny A.</au><au>Maguire, Maureen G.</au><aucorp>for the Dry Eye Assessment and Management (DREAM) Study Research Group</aucorp><aucorp>Dry Eye Assessment and Management (DREAM) Study Research Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of meibomian gland morphology with symptoms and signs of dry eye disease in the Dry Eye Assessment and Management (DREAM) study</atitle><jtitle>The ocular surface</jtitle><addtitle>Ocul Surf</addtitle><date>2020-10-01</date><risdate>2020</risdate><volume>18</volume><issue>4</issue><spage>761</spage><epage>769</epage><pages>761-769</pages><issn>1542-0124</issn><eissn>1937-5913</eissn><abstract>To describe associations between symptoms and signs of dry eye disease (DED) and meibomian gland (MG) morphology.
Cross-sectional study utilizing data from the Dry Eye Assessment and Management (DREAM) Study. Readers graded MG features in the middle third of upper and lower lids on infrared meibography images. Associations with signs and symptoms of DED were evaluated with adjustment for age and sex.
Among 268 patients, no MG features were associated with symptom scores (p > 0.08). Among 394 upper eyelids, better tear break-up times (<2, >2- <3.2and ≥ 3.2 s) were associated with more tortuous glands (mean (SD) 0.58(0.95), 0.83(1.2) and 1.14 (1.4), p = 0.01) and with higher scores on a composite score of MG features (21.90 (9.76), 23.29 (9.50), 26.26 (10.27); p = 0.02). Longer Schirmer test wetting lengths (0–5, >5–10, and >10 mm) were associated with increasing composite scores (22.02 (9.29), 23.80 (10.34), 24.96 (9.96), p = 0.03). Patients with Sjogren syndrome compared to other patients had fewer distorted MGs (mean 3.4 (2.3) vs 4.3 (2.3), p = 0.03) and fewer ghost glands (mean 0.33 (0.88) vs 0.89 (1.8), p = 0.006) in the upper lid.
In the DREAM study, most MG morphologic features were not associated with the severity of DED symptoms or signs. Tortuous glands and a higher composite score for MG features were associated with longer tear break-up times and longer Schirmer test length in the upper eyelid only. Patients with Sjogren syndrome had fewer distorted and ghost glands.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>32858234</pmid><doi>10.1016/j.jtos.2020.07.014</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-2027-2316</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | The ocular surface, 2020-10, Vol.18 (4), p.761-769 |
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| subjects | Adolescent Adult Aged Aged, 80 and over Cross-Sectional Studies Dry eye disease Dry Eye Syndromes - diagnosis Female Humans Male Meibography Meibomian Glands - diagnostic imaging Middle Aged Ocular surface disease index Sjogren's Syndrome Tear function tests Tears Young Adult |
| title | Association of meibomian gland morphology with symptoms and signs of dry eye disease in the Dry Eye Assessment and Management (DREAM) study |
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