The kappa opioid receptor antagonist aticaprant reverses behavioral effects from unpredictable chronic mild stress in male mice

Rationale Major depressive disorder is a leading cause of disability worldwide and is likely precipitated by chronic stress. Although many antidepressants are currently available, these drugs require weeks to months of daily administration before reduction of symptoms occurs and many patients remain...

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Veröffentlicht in:	Psychopharmacology 2020-12, Vol.237 (12), p.3715-3728
Hauptverfasser:	Jacobson, Moriah L., Wulf, Hildegard A., Browne, Caroline A., Lucki, Irwin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidepressants Benzamides - pharmacology Benzamides - therapeutic use Biomedical and Life Sciences Biomedicine Chronic Disease Cognition Complications and side effects Disease Models, Animal Dosage and administration Dose-Response Relationship, Drug Drug development Drug therapy Hedonic response Male Mental depression Mice Mice, Inbred C57BL Narcotic antagonists Narcotic Antagonists - pharmacology Narcotic Antagonists - therapeutic use Narcotics Neurosciences Opioid receptors (type kappa) Opioids Original Investigation Pharmacology/Toxicology Post traumatic stress disorder Psychiatry Pyrrolidines - pharmacology Pyrrolidines - therapeutic use Receptors Receptors, Opioid, kappa - antagonists & inhibitors Receptors, Opioid, kappa - physiology Reinforcement Social interaction Stress Stress (Psychology) Stress, Psychological - drug therapy Stress, Psychological - psychology Sucrose Swimming - psychology
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